Preadmission Use of Statins and Outcomes After Hospitalization With Pneumonia

Thomsen, Reimar Wernich; Riis, Anders H.; Kornum, Jette Brommann; Christensen, Steffen; Johnsen, Søren P; Sørensen, Henrik Toft

doi:10.1001/archinte.168.19.2081

Cited by 159 publications

(139 citation statements)

References 26 publications

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“…This association was however, not apparent in RCTs (Toh and Hernandez-Diaz, 2007). Further, previous observational Overall discussion and clinical implications studies have found statins to be associated with increased bone mineral density, improved prognosis after infections (Mortensen et al, 2005, Mortensen et al, 2008, Thomsen et al, 2008 and anti-inflammatory effects (Almog, 2003).…”

Section: Study I (Statin Study)mentioning

confidence: 92%

“…Consequently statins have been associated with angiogenesis, anti-inflammatory effects, and improved endothelial function among others (Bellosta et al, 2000). Further statins have been associated with improved prognosis after infections (Mortensen et al, 2005, Mortensen et al, 2008, Thomsen et al, 2008, Almog et al, 2004. These effects may play a role in implant survival after primary THA surgery (Figure 4.).…”

Section: Study I: Statinsmentioning

confidence: 99%

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Use of medications and risk of revision after primary total hip arthroplasty

Thillemann¹

2009

Acta Orthopaedica

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Section: Study I (Statin Study)mentioning

confidence: 92%

Section: Study I: Statinsmentioning

confidence: 99%

Use of medications and risk of revision after primary total hip arthroplasty

Thillemann¹

2009

Acta Orthopaedica

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“…As a result, investigators have evaluated the use of immunomodulatory agents in an attempt to control this exaggerated inflammatory response and reduce patient mortality. Corticosteroids are the primary immunomodulatory agents considered for patients with CAP, and results of several investigations [1][2][3][4][5][6][7][8][9][10] have been evaluated in recent system- ‡ Correspondence To: Timothy Wiemken MedCenter One 501 E. Broadway 120B Louisville, Kentucky 40202, USA Phone: 502-852-4627 Email: tim.wiemken@louisville.edu atic reviews and meta-analyses 11,12 Although steroids are considered important immunomodulatory agents for these patients, other considerations include macrolides [13][14][15][16][17][18] statins [19][20][21][22][23][24][25][26][27][28][29] and tissue factor pathway inhibitor 30 .…”

Section: Introductionmentioning

confidence: 99%

Untitled

2017

JRI

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Purpose: Patients with severe community-acquired pneumonia (CAP) are believed to have an exaggerated inflammatory response to bacterial infection. Therapies aiming to modulate the inflammatory response have been largely unsuccessful, perhaps reflecting that CAP is a heterogeneous disorder that cannot be modulated by a single anti-inflammatory approach. We hypothesize that the host inflammatory response to pneumonia may be characterized by distinct cytokine patterns, which can be harnessed for personalized therapies. Methods: Here, we use hierarchical cluster analysis of cytokines to examine if patterns of inflammatory response in 13 hospitalized patients with CAP can be defined. This was a secondary data analysis of the Community-Acquired Pneumonia Inflammatory Study Group (CAPISG) database. The following cytokines were measured in plasma and sputum on the day of admission: interleukin (IL)-1β , IL-1 receptor antagonist (IL-1ra), IL-6, CXCL8 (IL-8), IL-10, IL-12p40, IL-17, interferon (IFN)γ, tumor necrosis factor (TNF)α, and CXCL10 (IP-10). Hierarchical agglomerative clustering algorithms were used to evaluate clusters of patients within plasma and sputum cytokine determinations. Results: A total of thirteen patients were included in this pilot study. Cluster analysis identified distinct inflammatory response patterns of cytokines in the plasma, sputum, and the ratio of plasma to sputum. Conclusions: Inflammatory response patterns in plasma and sputum can be identified in hospitalized patients with CAP. Characterization of the local and systemic inflammatory response may help to better discriminate patients for enrollment into clinical trials of immunomodulatory therapies.

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“…Recent studies suggest that chronic treatment with statins would present beneficial effects for infection prevention and treatment. There is suggestion as well of a possible beneficial effect in ICU outcome [92,93,94,95,96,97,98,99,100,101]. Despite this evidence, several studies have only found a neutral effect [102], or even a greater mortality in patients treated with statins [103] in this environment.…”

Section: Introductionmentioning

confidence: 99%

Intelligent Management of Sepsis in the Intensive Care Unit

Ripoll

Rodríguez

Vellido

2012

Medical Applications of Intelligent Data Analysis

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Sepsis is a transversal pathology and one of the main causes of death in the Intensive Care Unit (ICU). It has in fact become the tenth most common cause of death in western societies. Its mortality rates can reach up to 60% for Septic Shock, its most acute manifestation. For these reasons, the prediction of the mortality caused by Sepsis is an open and relevant medical research challenge. This problem requires prediction methods that are robust and accurate, but also readily interpretable. This is paramount if they are to be used in the demanding context of real-time decision making at the ICU. In this brief contribution, three different methods are presented. One is based on a variant of the well-known support vector machine (SVM) model and provides and automated ranking of relevance of the mortality predictors while the other two are based on logistic-regression and logistic regression over latent Factors. The reported results show that the methods presented outperform in terms of accuracy alternative techniques currently in use in clinical settings, while simultaneously assessing the relative impact of individual pathology indicators.

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Preadmission Use of Statins and Outcomes After Hospitalization With Pneumonia

Cited by 159 publications

References 26 publications

Use of medications and risk of revision after primary total hip arthroplasty

Use of medications and risk of revision after primary total hip arthroplasty

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Intelligent Management of Sepsis in the Intensive Care Unit

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