Prealbumin, retinol-binding protein, and total salivary IgA in children with AIDS

Slobodianik, Nora; Pallaro, Anabel; Río, M. E.; Barbeito, S.; Strasnoy, Irene; Franchello, A.; Casella, Erasmo Barbante; Torales, Maria Rosa; Giraudi, Vera; Ramos, Oswaldo L.

doi:10.1093/clinchem/42.3.471

Cited by 3 publications

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“…Only two patients with AIDS and one HIV þ patient showed transthyretin values lower than 20•0 mg/dl, this value is associated with protein deficiency 22,24 . In contrast, previous results performed on forty-five children with AIDS, diagnosed according to the criteria of the Centers for Disease Control and Prevention, showed lower levels of transthyretin and RBP than laboratory reference values 27 . Around 40 % of HIV þ and AIDS patients presented ceruloplasmin levels above 65 mg/dl 15 .…”

Section: Discussioncontrasting

confidence: 76%

Nutritional status in patients with HIV infection and AIDS

2007

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The aim of this study was to evaluate the nutritional status of adults with HIV infection or with AIDS through the use of biochemical parameters. The study was performed on 43 patients (19 HIV þ and 24 AIDS patients), between 26 and 44 years of age, from low and medium socioeconomic status, with access to health care services; 35 patients were under highly active antiretroviral therapy (HAART) treatment. Body weight and height were determined, and the Body Mass Index calculated (kg/m 2 ). Blood samples were collected from fasting patients. Plasma cholesterol (total, HDL and LDL), triacylglycerol, total protein, apolipoproteins A-I and B, albumin, transthyretin, retinol binding protein, and ceruloplasmin concentrations were determined. Plasma levels of zinc, copper, and selenium were determined in a haemolysis-free sample by flame atomic absorption spectrometry. Statistical analyses were performed with the Student's t-test. AIDS patients showed changes in biochemical parameters, particularly an increase in fibrinogen and a trend to decreased transthyretin levels. These findings stress the importance of the inclusion of functional biochemical parameters in the periodic evaluation of these patients. This would allow an early assessment of the need for appropriate nutritional support, implemented along with the specific retroviral treatment. This would aim at delaying the progression of the disease, and might improve the prospects of survival and quality of life.

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Section: Discussioncontrasting

confidence: 76%

Nutritional status in patients with HIV infection and AIDS

2007

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“…The HIV-infected groups also seem to differ. For example, the total IgA concentration in unstimulated whole saliva was lower in HIV-infected subjects (3) and in children with AIDS (9). In contrast, IgA concentration in stimulated whole saliva of AIDS patients was higher (10).…”

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confidence: 86%

Salivary albumin, total protein, IgA, IgG and IgM concentrations and occurrence of some periodontopathogens in HIV‐infected patients: a 2‐year follow‐up study

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et al. 2001

J Oral Pathology Medicine

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HIV infection reduces oral defensive mechanisms and may affect mucosal integrity. Differences in salivary protein concentrations and periodontopathogenic bacteria were studied in 56 HIV-infected patients with respect to their disease phase. Thirty-three patients were followed up for 2 years. Fifty-three healthy subjects of corresponding age and sex were studied as controls. At baseline, salivary albumin, total protein, IgA, and IgM levels were significantly higher (P<0.05-0.0001) in all phases of HIV infection, except the asymptomatic (ASX) phase, when compared with the control group. IgG levels were significantly increased in all phases except the ASX phase (P<0.05). After 2 years, salivary total protein, IgG, and IgM levels were still higher (P<0.05-0.005) in all HIV phases when compared with the control group (P<0.05-0.005). The albumin level was significantly higher in the ASX phase (P<0.005) and in the AIDS-related complex phase (ARC) (P<0.05), while the increase in IgA level was significant only in the ARC phase (P<0.005). Periodontopathogenic bacteria analyzed by PCR were detected both in the patients and the non-infected, but a statistically significant difference in the carriage percentage between the follow-up lymphadenopathy syndrome phase (LAS) and the control group was found only in Porphyromonas gingivalis (P<0.05) and Bacteroides forsythus (P< 0.0001). Thus, HIV infection appeared to cause a significant increase in the studied salivary proteins, suggesting leakage of serum components into the mouth.

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