Prebiotic, immuno-stimulating and gut microbiota-modulating effects of Lycium barbarum polysaccharide

Zhu, Weifeng; Zhou, Shuxin; Liu, Jihua; McLean, Robert; Chu, Weihua

doi:10.1016/j.biopha.2019.109591

Cited by 128 publications

(66 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Butyryl-Coenzyme A CoA transferase is an important butyrate gene, and GBPS supplementation increased its expression in butyrate-producing bacteria such as the Clostridium cluster XIVa group including Lachnospiraceae , Faecailbacterium prausnitzii, and Ruminococcaceae [ 164 ]. The GBPS prebiotic effects increased the populations of Firmicutes , Akkermansia , Proteobacteria , Lactobacillus , and Prevotellaceae [ 165 ].…”

Section: Goji Berriesmentioning

confidence: 99%

Select Polyphenol-Rich Berry Consumption to Defer or Deter Diabetes and Diabetes-Related Complications

et al. 2020

View full text Add to dashboard Cite

Berries are considered “promising functional fruits” due to their distinct and ubiquitous therapeutic contents of anthocyanins, proanthocyanidins, phenolic acids, flavonoids, flavanols, alkaloids, polysaccharides, hydroxycinnamic, ellagic acid derivatives, and organic acids. These polyphenols are part of berries and the human diet, and evidence suggests that their intake is associated with a reduced risk or the reversal of metabolic pathophysiologies related to diabetes, obesity, oxidative stress, inflammation, and hypertension. This work reviewed and summarized both clinical and non-clinical findings that the consumption of berries, berry extracts, purified compounds, juices, jams, jellies, and other berry byproducts aided in the prevention and or otherwise management of type 2 diabetes mellitus (T2DM) and related complications. The integration of berries and berries-derived byproducts into high-carbohydrate (HCD) and high-fat (HFD) diets, also reversed/reduced the HCD/HFD-induced alterations in glucose metabolism-related pathways, and markers of oxidative stress, inflammation, and lipid oxidation in healthy/obese/diabetic subjects. The berry polyphenols also modulate the intestinal microflora ecology by opposing the diabetic and obesity rendered symbolic reduction of Bacteroidetes/Firmicutes ratio, intestinal mucosal barrier dysfunction-restoring bacteria, short-chain fatty acids, and organic acid producing microflora. All studies proposed a number of potential mechanisms of action of respective berry bioactive compounds, although further mechanistic and molecular studies are warranted. The metabolic profiling of each berry is also included to provide up-to-date information regarding the potential anti-oxidative/antidiabetic constituents of each berry.

show abstract

Section: Goji Berriesmentioning

confidence: 99%

Select Polyphenol-Rich Berry Consumption to Defer or Deter Diabetes and Diabetes-Related Complications

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Firmicutes , Bacteroidetes , Proteobacteria , and Actinobacteria are the four major bacterial phyla that exist in over 90% of the normal human gut (Qin et al., 2010). Lycium barbarum polysaccharide significantly enhanced the growth of beneficial bacteria including Lactobacillus acidophilus and Bifidobacterium longum and increased the percentage of some potential probiotic genera such as Akkermansia , Lactobacillus , and Prevotellaceae at the genus level (Zhu et al., 2020). Polysaccharides can also serve as a prebiotic that is selectively utilized by host microorganisms in the human gut, acting as a carbon source for growth and conferring a health benefit (Neri‐Numa et al., 2020).…”

Section: Polysaccharides and Gut Microbiotamentioning

confidence: 99%

Regulation effects of indigestible dietary polysaccharides on intestinal microflora: An overview

Ahmed

Yao

et al. 2020

J. Food Biochem.

View full text Add to dashboard Cite

The human intestinal contains rich and diverse microbiota that utilizes a variety of polysaccharides. The intestinal microflora extends the metabolic functions of the body, obtaining energy from indigestible dietary polysaccharides. It is not only a highly competitive environment but also a comprehensive collaboration for these polysaccharides, as the microbiota work to maximize the energy harvested from them through the intestine. Indigestible dietary polysaccharides help to manage colon health and host health by affecting the gut microbial population. These polysaccharides also influence the metabolic activity of the intestinal microbiota by stimulating the formation of SCFAs. Most of these metabolic activities affect host physiology because the epithelium absorbs secondary metabolites and end products or transports them to the liver, where they could exert other beneficial effects. This article reviews the carbohydrates existing in the human intestine, the regulating actions of indigestible polysaccharides on intestinal microflora, and the molecular basis of the degradation process of these polysaccharides. Practical applications Large deals of researches have shown that indigestible polysaccharides possess an outstanding regulation effect on the intestinal microflora, which indicates that indigestible polysaccharides have the potential to be used as prebiotics in the functional food and pharmaceutical industries. However, it is not clear how gut microbiota metabolizes these dietary polysaccharides, and how the resulting gut metabolites may further affect the intestinal microflora population and metabolism. This paper reviews the indigestible dietary polysaccharides existing in the human intestine, the regulation of polysaccharides on gut microbiota, and the molecular basis of the degradation process of these polysaccharides. This review helps to better understand the relationship between indigestible dietary polysaccharides and intestinal microflora, which will provide powerful evidence for the potential use of these polysaccharides as functional foods.

show abstract

“…The prebiotic activity of the starch and protein digesta products of the sample were assessed in vitro through studying the growth of L. plantarum and L. delbrueckii as described by Zhu et al. (2020) with slight modifications. Different concentrations of the sample digesta product (2.5, 5, 7.5, and 10%, w/v) were added to the MRS basal medium as the experimental groups.…”

Section: Methodsmentioning

confidence: 99%

Development of weaning food with prebiotic effects based on roasted or extruded quinoa and millet flour

Dong

Zhu

et al. 2021

Journal of Food Science

View full text Add to dashboard Cite

Weaning is the gradual process of introducing solids or semisolid foods into an infant's diet, in order to ensure their healthy growth. This study developed two kinds of formula weaning food based on roasted or extruded quinoa and millet flour, and evaluated their quality. A fructo‐oligosaccharide (FOS)/galacto‐oligosaccharide (GOS) mix was added to provide the prebiotic potential. The protein contents of the roasted quinoa‐millet complementary food (RQMCF) and extruded quinoa‐millet complementary food (EQMCF) were 16.7% and 17.74% higher, respectively, than that of commercial millet complementary food (CMCF). Both RQMCF and EQMCF provided sufficient levels of energy and minerals. Extrusion provided the foods with a lower viscosity, and higher solubility and water absorption ability than roasting. In vitro digestion results showed that EQMCF exhibited the highest starch and protein digestibility (89.76% and 88.72%, respectively) followed by RQMCF (87.75% and 86.63%) and CMCF (83.35% and 81.54%). The digestas of RQMCF and EQMCF after in vitro digestion exhibited prebiotic effects by promoting the growth of the probiotics (Lactobacillus plantarum and Lactobacillus delbrueckii). These results will contribute to developing complementary weaning foods for infants. Practical Application This study has shown that extrusion is an efficient and stable processing method for producing infant complementary foods with low density, balanced nutrition, and high levels of starch and protein digestibility. Extruded quinoa‐millet prebiotic complementary food can also promote the proliferation of probiotics. This will provide a new direction for developing novel infant formula weaning foods.

show abstract

Prebiotic, immuno-stimulating and gut microbiota-modulating effects of Lycium barbarum polysaccharide

Cited by 128 publications

References 36 publications

Select Polyphenol-Rich Berry Consumption to Defer or Deter Diabetes and Diabetes-Related Complications

Select Polyphenol-Rich Berry Consumption to Defer or Deter Diabetes and Diabetes-Related Complications

Regulation effects of indigestible dietary polysaccharides on intestinal microflora: An overview

Development of weaning food with prebiotic effects based on roasted or extruded quinoa and millet flour

Contact Info

Product

Resources

About