Prebiotic Syntheses Under Shock in the Water – Formamide – Potassium Bicarbonate – Sodium Hydroxide System

Штырлин, В. Г.; Borissenok, Valery A.; Serov, Nikita Yu.; Simakov, V. G.; Bragunets, Vyacheslav A.; Trunin, I. R.; Tereshkina, I. A.; Кошкин, С. А.; Bukharov, Mikhail S.; Gilyazetdinov, Edward M.; Shestakov, E. E.; Sirotkina, A. G.; Zakharov, A. V.

doi:10.1007/s11084-019-09575-8

Cited by 6 publications

(1 citation statement)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The second important output of the serpentinization reaction is the production of a high concentration of hydroxyl so that the waters of the primitive lakes and oceans were alkaline and compatible with HCONH 2 condensation and with soda lakes of the African Rift Valley [11,12]. When the first felsic rocks, granites and granitoids, started to emerge from the alkaline oceans they became enriched in silica (pH 12.2).…”

Section: The Role Of Minerals and Mineral Self-organization In Prebiotic Chemistrymentioning

confidence: 99%

Prebiotic Organic Chemistry of Formamide and the Origin of Life in Planetary Conditions: What We Know and What Is the Future

Bizzarri

Saladino

Delfino

et al. 2021

IJMS

View full text Add to dashboard Cite

The goal of prebiotic chemistry is the depiction of molecular evolution events preceding the emergence of life on Earth or elsewhere in the cosmos. Plausible experimental models require geochemical scenarios and robust chemistry. Today we know that the chemical and physical conditions for life to flourish on Earth were at work much earlier than thought, i.e., earlier than 4.4 billion years ago. In recent years, a geochemical model for the first five hundred million years of the history of our planet has been devised that would work as a cradle for life. Serpentinization processes in the Hadean eon affording self-assembled structures and vesicles provides the link between the catalytic properties of the inorganic environment and the impressive chemical potential of formamide to produce complete panels of organic molecules relevant in pre-genetic and pre-metabolic processes. Based on an interdisciplinary approach, we propose basic transformations connecting geochemistry to the chemistry of formamide, and we hint at the possible extension of this perspective to other worlds.

show abstract

Section: The Role Of Minerals and Mineral Self-organization In Prebiotic Chemistrymentioning

confidence: 99%

Prebiotic Organic Chemistry of Formamide and the Origin of Life in Planetary Conditions: What We Know and What Is the Future

Bizzarri

Saladino

Delfino

et al. 2021

IJMS

View full text Add to dashboard Cite

show abstract

Urea and Acetamide Rich Solutions Circumvent the Strand Inhibition Problem to Allow Multiple Rounds of DNA and RNA Copying

et al. 2021

View full text Add to dashboard Cite

For decades prebiotic chemists have attempted to achieve replication of RNA under prebiotic conditions with only limited success. One of the long-recognized impediments to achieving true replication of a duplex (copying of both strands) is the socalled strand inhibition problem. Specifically, while the two strands of an RNA (or DNA) duplex can be separated by heating, upon cooling the strands of a duplex will reanneal before mononucleotide or oligonucleotide substrates can bind to the individual strands. Here we demonstrate that a class of plausible prebiotic solvents, when coupled with thermal cycling and varying levels of hydration, circumvents the strand inhibition problem, and allows multiple rounds of information transfer from both strands of a duplex (replication). Replication was achieved by simultaneous ligation of oligomers that bind to their templates with the aid of the solvents. The solvents used consisted of concentrated solutions of urea and acetamide in water (UAcW), components that were likely abundant on the early Earth. The UAcW solvent system favors the annealing of shorter strands over the re-annealing of long strands, thereby circumventing strand inhibition. We observed an improvement of DNA and RNA replication yields by a factor of 100 × over aqueous buffer. Information transfer in the UAcW solvent system is robust, being achieved for a range of solvent component ratios, various drying conditions, and in the absence or presence of added salts.

show abstract

The kinetics and mechanisms of reactions in the flow systems glycine–sodium trimetaphosphate–imidazoles: the crucial role of imidazoles in prebiotic peptide syntheses

2020

View full text Add to dashboard Cite

Prebiotic Syntheses Under Shock in the Water – Formamide – Potassium Bicarbonate – Sodium Hydroxide System

Cited by 6 publications

References 55 publications

Prebiotic Organic Chemistry of Formamide and the Origin of Life in Planetary Conditions: What We Know and What Is the Future

Prebiotic Organic Chemistry of Formamide and the Origin of Life in Planetary Conditions: What We Know and What Is the Future

Urea and Acetamide Rich Solutions Circumvent the Strand Inhibition Problem to Allow Multiple Rounds of DNA and RNA Copying

The kinetics and mechanisms of reactions in the flow systems glycine–sodium trimetaphosphate–imidazoles: the crucial role of imidazoles in prebiotic peptide syntheses

Contact Info

Product

Resources

About