Prebiotics: A Novel Approach to Treat Hepatocellular Carcinoma

Fatima, Naz; Akhtar, Tasleem; Sheikh, Nadeem

doi:10.1155/2017/6238106

Cited by 22 publications

(17 citation statements)

References 96 publications

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“…The same role is exerted also by pro-anthocyanidins, found for example in almonds, grapes and chocolate [329]. Phenols contained in curcumin were reported to be able to arrest cell cycle and inhibit proliferation and metastasis [330].…”

Section: Antioxidant Approach For the Treatment Of Hepatocellular Carmentioning

confidence: 94%

Changes in Glutathione Content in Liver Diseases: An Update

et al. 2021

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Glutathione (GSH), a tripeptide particularly concentrated in the liver, is the most important thiol reducing agent involved in the modulation of redox processes. It has also been demonstrated that GSH cannot be considered only as a mere free radical scavenger but that it takes part in the network governing the choice between survival, necrosis and apoptosis as well as in altering the function of signal transduction and transcription factor molecules. The purpose of the present review is to provide an overview on the molecular biology of the GSH system; therefore, GSH synthesis, metabolism and regulation will be reviewed. The multiple GSH functions will be described, as well as the importance of GSH compartmentalization into distinct subcellular pools and inter-organ transfer. Furthermore, we will highlight the close relationship existing between GSH content and the pathogenesis of liver disease, such as non-alcoholic fatty liver disease (NAFLD), alcoholic liver disease (ALD), chronic cholestatic injury, ischemia/reperfusion damage, hepatitis C virus (HCV), hepatitis B virus (HBV) and hepatocellular carcinoma. Finally, the potential therapeutic benefits of GSH and GSH-related medications, will be described for each liver disorder taken into account.

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Section: Antioxidant Approach For the Treatment Of Hepatocellular Carmentioning

confidence: 94%

Changes in Glutathione Content in Liver Diseases: An Update

et al. 2021

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“…Based on the chemical structure of inulin, the two main groups of prebiotics evaluated in humans are fructans and galactans (Cummings & Macfarlane, ; Fatima, Akhtar, & Sheikh, ). However, the MOS, derived from the cell wall of the yeast Saccharomyces cerevisiae has been gaining research interest (Hajati & Rezaei, ).…”

Section: Introductionmentioning

confidence: 99%

Effects of the prebiotic mannan oligosaccharide on the experimental periodontitis in rats

Levi

Novais

Dias

et al. 2018

J Clinic Periodontology

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“…Although our results indicated that only miR-196a2 was associated with the susceptibility of HCC, and there was not enough evidence to support the association in miR-146, miR-149 or miR-499, the negative results still could not be ignored and should be interpreted cautiously. This is due to the occurrence of HCC is the result of multiple factors, in addition to complex genetic factors, there are hepatitis, aflatoxin exposure, Hepatitis C virus infection and other factors ( 74 – 76 ). Instead the incidence of HCC, gene variation may only cause increased susceptibility in a certain extent ( 77 ).…”

Section: Discussionmentioning

confidence: 99%

MiRNA Polymorphisms and Hepatocellular Carcinoma Susceptibility: A Systematic Review and Network Meta-Analysis

Zhang

et al. 2021

Front. Oncol.

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BackgroundHepatocellular carcinoma (HCC) is an intractable public health threat worldwide, representing the second leading cause of cancer-related mortality, with limited early detection and therapeutic options. Recent findings have revealed that the susceptibility of HCC is closely related to microRNA (miRNA). We performed this systematic review with a network meta-analysis to investigated four single nucleotide polymorphisms (SNPs) that most regularly reported in miRNAs, exploring their involvement in HCC susceptibility and interaction with hepatitis B virus (HBV).MethodsDatabases were reviewed for related studies published up to May 2019 to identify all studies that compared genotypes of miR-146a rs2910164, miR-149 rs2292832, miR-196a2 rs11614913, and miR-499 rs3746444 with no language and date restrictions. A pairwise meta-analysis was performed to estimate pooled odds ratios and 95% confidence intervals incorporating heterogeneity to assess the relationship between four miRNA polymorphisms and HCC. To further clarify the effect of polymorphisms on HCC, a Bayesian network meta-analysis was conducted to combine the effective sizes of direct and indirect comparisons. Calculations were performed by R version 3.6.1 and STATA 14.0. All steps were performed according to PRISMA guidelines.ResultsA total of 20 studies were enrolled in this network meta-analysis, providing 5,337 hepatocellular carcinoma cases and 6,585 controls. All included studies had an acceptable quality. Pairwise meta-analysis demonstrated that miR-196a2 rs11614913 was significantly associated with the susceptibility of HCC, while the other three SNPs were not found to have a significant association. In the analysis of HCC patients under different HBV infection status, only miR-196a2 revealed correlation of threefold risk. The network results showed no significant difference in the distribution of genotype frequencies except for miR-196a2, which appeared to have the highest superiority index when comparing and ranking four SNPs.ConclusionMiR-196a2 rs11614913 was significantly associated with the susceptibility of HCC, especially for HBV- related HCC, and that individuals with TC/CC were more susceptible. No significant association was found in the other three miRNA genes. MiR-196a2 could serve as the best predictor of susceptibility in HCC.

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Prebiotics: A Novel Approach to Treat Hepatocellular Carcinoma

Cited by 22 publications

References 96 publications

Changes in Glutathione Content in Liver Diseases: An Update

Changes in Glutathione Content in Liver Diseases: An Update

Effects of the prebiotic mannan oligosaccharide on the experimental periodontitis in rats

MiRNA Polymorphisms and Hepatocellular Carcinoma Susceptibility: A Systematic Review and Network Meta-Analysis

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