Prebiotics and probiotics as potential therapy for cognitive impairment

Romo‐Araiza, Alejandra; Ibarra, Antonio

doi:10.1016/j.mehy.2019.109410

Cited by 26 publications

(21 citation statements)

References 72 publications

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“…Prebiotics stimulate probiotic growth and the formation of SCFAs, thus enhancing the beneficial effects of probiotics. Probiotics and prebiotics could be considered as possible treatment options for cognitive impairment [ 9 ]. Thus, the combined use of probiotics and prebiotics in synbiotic compositions could be the most effective approach to modulate the intestinal microbiota and to prevent and provide complex treatment for various diseases including bacterial superinfections.…”

Section: Introductionmentioning

confidence: 99%

A Study on the Synbiotic Composition of Bifidobacterium bifidum and Fructans from Arctium lappa Roots and Helianthus tuberosus Tubers against Staphylococcus aureus

et al. 2021

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A number of mechanisms have been proposed explaining probiotics and prebiotics benefit human health, in particular, probiotics have a suppression effect on pathogen growth that can be enhanced with the introduction of prebiotics. In vitro models enhanced with computational biology can be useful for selecting a composition with prebiotics from new plant sources with the greatest synergism. Water extracts from burdock root and Jerusalem artichoke tubers were purified by ultrafiltration and activated charcoal and concentrated on a rotary evaporator. Fructans were precipitated with various concentrations of ethanol. Bifidobacterium bifidum 8 VKPM AC−2136 and Staphylococcus aureus ATCC 43300 strains were applied to estimate the synbiotic effect. The growth of bifidobacteria and staphylococci in monocultures and cocultures in broths with glucose, commercial prebiotics, as well as isolated fructans were studied. The minimum inhibitory concentrations (MICs) of lactic and acetic acids for the Staphylococcus strain were determined. A quantitative model joining the formation of organic acids by probiotics as antagonism factors and the MICs of pathogens (as the measure of their inhibition) was tested in cocultures and showed a high predictive value (R2 ≥ 0.86). The synbiotic factor obtained from the model was calculated based on the experimental data and obtained constants. Fructans precipitated with 20% ethanol and Bifidobacterium bifidum have the greater synergism against Staphylococcus.

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Section: Introductionmentioning

confidence: 99%

A Study on the Synbiotic Composition of Bifidobacterium bifidum and Fructans from Arctium lappa Roots and Helianthus tuberosus Tubers against Staphylococcus aureus

et al. 2021

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“…The administration of SLAB51, a probiotic formulation of lactic acid bacteria and bifidobacteria, activates SIRT1 and promotes antioxidant and neuroprotective effects in a mouse model of Alzheimer's disease [170]. All together these results seem to indicate that probiotics may be beneficial in maintaining brain function; although a solid link with neurogenesis is still missing, the generation of SCFAs modulation of oxidative stress and inflammation and the upregulation of hippocampal BDNF all represent potential "pro-neurogenic" activities of probiotics and prebiotics to be further investigated in the appropriate experimental models [61].…”

Section: Probiotics/prebioticsmentioning

confidence: 96%

“…This imbalance, in turn, affects lipid metabolism and decreases the endocannabinoid signalling system, thus reducing hippocampal AN. Of note, dysbiosis frequently accompanies ageing and may lead to chronic inflammation and a decrease in pro-neurogenic bacterial metabolites (such as SCFAs) in the senescent intestine [61].…”

Section: Evidence For the Connection Between Intestinal Microbiota An...mentioning

confidence: 99%

The Influence of Gut Microbiota on Neurogenesis: Evidence and Hopes

Sarubbo

Cavallucci

Pani

2022

Cells

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Adult neurogenesis (i.e., the life-long generation of new neurons from undifferentiated neuronal precursors in the adult brain) may contribute to brain repair after damage, and participates in plasticity-related processes including memory, cognition, mood and sensory functions. Among the many intrinsic (oxidative stress, inflammation, and ageing), and extrinsic (environmental pollution, lifestyle, and diet) factors deemed to impact neurogenesis, significant attention has been recently attracted by the myriad of saprophytic microorganismal communities inhabiting the intestinal ecosystem and collectively referred to as the gut microbiota. A growing body of evidence, mainly from animal studies, reveal the influence of microbiota and its disease-associated imbalances on neural stem cell proliferative and differentiative activities in brain neurogenic niches. On the other hand, the long-claimed pro-neurogenic activity of natural dietary compounds endowed with antioxidants and anti-inflammatory properties (such as polyphenols, polyunsaturated fatty acids, or pro/prebiotics) may be mediated, at least in part, by their action on the intestinal microflora. The purpose of this review is to summarise the available information regarding the influence of the gut microbiota on neurogenesis, analyse the possible underlying mechanisms, and discuss the potential implications of this emerging knowledge for the fight against neurodegeneration and brain ageing.

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“…In addition to polyphenols, probiotics can also improve cognitive function and spatial memory [9,28]. Probiotics refer to bacteria that support health by changing the composition of the gut microbiome [29].…”

Section: Probioticsmentioning

confidence: 99%