Precancerous Lesions and Liver Atrophy as Risk Factors for Hepatolithiasis-Related Death after Liver Resection for Hepatolithiasis

Miyazaki, Toru; Shinkawa, Hiroji; Takemura, Shigekazu; Tanaka, Shogo; Amano, Ryosuke; Kimura, Kenjiro; Ohira, Go; Nishio, Kenji; Kinoshita, Masahiko; Tsuchi, Jun; Ishihara, Atsushi; Eguchi, Shimpei; Shirai, Daisuke; Yamamoto, Takatsugu; Wakasa, Kenichi; Kawada, Norifumi; Kubo, Shoji

doi:10.31557/apjcp.2020.21.12.3647

Cited by 5 publications

(2 citation statements)

References 22 publications

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“…If there is evidence of biliary strictures or history of biliary reconstruction, these patients require a more aggressive management, including invasive methods to remove stones and dilate stenotic ducts. Cases where hepatic atrophy is present should ideally undergo hepatectomy[ 71 ]. The most important goals during treatment of hepatolithiasis are removal of stones, resolution of strictures and prevention of cholangitis to hinder progression of the disease and development of CCA[ 72 ].…”

Section: Managementmentioning

confidence: 99%

Hepatolithiasis: Epidemiology, presentation, classification and management of a complex disease

Motta,

Saffioti,

Mavroeidis

2024

World J Gastroenterol

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The term hepatolithiasis describes the presence of biliary stones within the intrahepatic bile ducts, above the hilar confluence of the hepatic ducts. The disease is more prevalent in Asia, mainly owing to socioeconomic and dietary factors, as well as the prevalence of biliary parasites. In the last century, owing to migration, its global incidence has increased. The main pathophysiological mechanisms involve cholangitis, bile infection and biliary strictures, creating a self-sustaining cycle that perpetuates the disease, frequently characterised by recurrent episodes of bacterial infection referred to as syndrome of “recurrent pyogenic cholangitis”. Furthermore, long-standing hepatolithiasis is a known risk factor for development of intrahepatic cholangiocarcinoma. Various classifications have aimed at providing useful insight of clinically relevant aspects and guidance for treatment. The management of symptomatic patients and those with complications can be complex, and relies upon a multidisciplinary team of hepatologists, endoscopists, interventional radiologists and hepatobiliary surgeons, with the main goal being to offer relief from the clinical presentations and prevent the development of more serious complications. This comprehensive review provides insight on various aspects of hepatolithiasis, with a focus on epidemiology, new evidence on pathophysiology, most important clinical aspects, different classification systems and contemporary management.

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Section: Managementmentioning

confidence: 99%

Hepatolithiasis: Epidemiology, presentation, classification and management of a complex disease

Motta,

Saffioti,

Mavroeidis

2024

World J Gastroenterol

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“…Nevertheless, the vast majority of cancers have obvious precancerous lesions. Thus, identifying precancerous lesions at the early stage of the disease is a very valuable opportunity for early diagnosis and treatment ( 14 , 15 ).…”

Section: Introductionmentioning

confidence: 99%

Diagnostic test of dynamic computed tomography in early gastrointestinal lymphoma and precancerous lesions

Chen¹,

Yu²,

Zeng³

et al. 2022

Transl Cancer Res TCR

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Background In recent years, with the development of imaging technology, the accurate diagnosis of precancerous lesions of digestive system and early lymphoma has attracted wide attention in the medical field. Methods In this study, 82 patients with gastrointestinal diseases, including 32 patients with early gastrointestinal lymphoma and 50 patients with gastrointestinal precancerous lesions, underwent dynamic contrast-enhanced computed tomography (CT) scanning. The difference ( δ 1, δ 2) and ratio ( Q1 , Q2 ) of density between arterial phase, portal phase and plain scan were measured and compared, and the receiver operating characteristic (ROC) curve of the subjects was drawn. Results The results showed no statistically significant differences in the general condition of patients or a difference for the results of the arterial phase δ 1 and Q1 between the two groups (P>0.05). However, the portal venous phase δ 2 and Q2 in the early lymphoma group and in precancerous lesion group were 29.50±6.05, 41.55±10.10 Hounsfield units (HU), and 1.70±0.05, 2.06±0.31, respectively. The area under the ROC curve (AUC) values for δ 2 and Q2 to identify the two diseases were 0.755 and 0.878, respectively. When δ 2 and Q2 were 35.63 and 1.86 HU, the specificity was 89.60% and 67.50%, and sensitivity was 89.60% and 64.90%, respectively. When the two indexes, δ 2 and Q2 , were combined, the specificity and sensitivity of diagnosis were 98.99% and 56.80%, respectively. Conclusions Dynamic contrast-enhanced CT can effectively distinguish early gastrointestinal lymphoma from precancerous lesions and improve the diagnostic accuracy.

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Clinical, histopathological, and immunohistochemical spectrum of hepatolithiasis: a tertiary care center-based study from north India

et al. 2023

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Precancerous Lesions and Liver Atrophy as Risk Factors for Hepatolithiasis-Related Death after Liver Resection for Hepatolithiasis

Cited by 5 publications

References 22 publications

Hepatolithiasis: Epidemiology, presentation, classification and management of a complex disease

Hepatolithiasis: Epidemiology, presentation, classification and management of a complex disease

Diagnostic test of dynamic computed tomography in early gastrointestinal lymphoma and precancerous lesions

Clinical, histopathological, and immunohistochemical spectrum of hepatolithiasis: a tertiary care center-based study from north India

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