Wetlands are periodically flooded terrestrial and aquatic environments, which provide benefits to a community known as ecosystem services (ESs). This research identified, classified, and spatialized the level of relevance of ecosystem services provided by wetlands in the Galinhos-Guamaré semi-arid estuarine system, State of Rio Grande do Norte, Northeast Brazil. ESs were analyzed using the Common International Classification of Ecosystem Services (CICES), v.4.3, and geographic information system (GIS) using a mosaic of Sentinel-2A images. The services provided by wetlands were classified into provision, regulation and maintenance, and cultural sections, with six divisions, 12 groups, and 22 classes being identified. The capacity of a number of wetlands to provide services was identified in 34 mangrove forests, 32 estuaries, 30 tidal flats, 26 solar saltworks, 23 apicum (tidal flats), and seven in shrimp ponds. However, it is noteworthy that these habitats are associated with ecosystems with great ecological, socioeconomic, and cultural importance, where the general approach presented here requires more detailed research in each macrohabitat, which should be considered as a priority for conservation.