Precipitation kinetics and biological properties of chitosan microparticles produced using supercritical assisted atomization

Wu, Hsien-Tsung; Lee, Hsiao-Kang; Chen, Hou-Cyuan; Chien, Liang-Jung

doi:10.1016/j.cherd.2015.09.021

Cited by 7 publications

(8 citation statements)

References 48 publications

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“…The PSD (Figure 5a) and mean size of the PEG particles (Figure 5b) increased with the concentration of the PEG solution, thus indicating that the high viscosity of the high concentration PEG solution resulted in larger liquid droplets and increased PEG particle sizes. Similar results have been reported, mostly for relevant SAA processes [13,14,15,16,17,18,25,26,27,28,29,30,31,32].…”

Section: Resultssupporting

confidence: 89%

Formation of Polyethylene Glycol Particles Using a Low-Temperature Supercritical Assisted Atomization Process

Tsai

2019

Molecules

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Polyethylene glycol (PEG) particles were prepared using low-temperature supercritical assisted atomization (LTSAA) with carbon dioxide as the spraying medium or the co-solute and acetone as the solvent. The effects of several key factors on the particle size were investigated. These factors included the concentration of the PEG solution, precipitator temperature, saturator temperature, ratio of the volumetric flow rate of carbon dioxide to the PEG solution, and the molecular weight of PEG. Spherical and non-aggregated PEG particles, with a mean size of 1.7–3.2 µm, were obtained in this study. The optimal conditions to produce fine particles were found to be a low concentration of the PEG solution, a low precipitator temperature, and low molecular weight of the PEG. The phase behavior of the solution mixture in the saturator presented a qualitative relationship. At the optimized volumetric flow rate ratios, the composition of CO2 in the feed streams was near the bubble points of the saturator temperatures. X-ray and differential scanning calorimetry analyses indicated that LTSAA-treated PEG had a reduced degree of crystallinity, which could be modulated via the precipitator temperature. PEG microparticles prepared by a LTSAA process would be promising carriers for drug-controlled formulations of PEG-drug composite particles.

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Section: Resultssupporting

confidence: 89%

Formation of Polyethylene Glycol Particles Using a Low-Temperature Supercritical Assisted Atomization Process

Tsai

2019

Molecules

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“…1 gradually disappears as the CS content in the TPH-CS composite microparticles (high Z-value samples) increases. Moreover, the morphologies of high Z-value TPH-CS composite microparticles are similar to those observed in a previous study (Wu et al, 2015) of SAA-CS with sub-micrometer spherical CS particles and narrow PSDs, as shown in Fig. 2.…”

Section: A B Csupporting

confidence: 87%

“…Since chitosan is soluble in acidic aqueous solutions, 1.2% (v/v) aqueous acetic acid was used in this study. According to a previous study (Wu et al, 2015), mixing the same volumes of ethanol and 1.2% (v/v) aqueous acetic acid (denoted as 50% (v/v) aqueous ethanol) as a solvent could reduce the CS particle sizes compared to using 1.2% (w/v) aqueous acetic acid as a solvent; this is because decompressive atomization was improved by the increased solubility of CO 2 in the liquid phase. Therefore, in this study, 50% (v/v) aqueous ethanol was used as a solvent during the SAA process to prepare TPH-CS composite particles.…”

Section: Characterization Of Tph-cs Composite Particlesmentioning

confidence: 97%

“…Therefore, in this study, 50% (v/v) aqueous ethanol was used as a solvent during the SAA process to prepare TPH-CS composite particles. The optimal precipitation parameters of the SAA process were also taken from this previous study (Wu et al, 2015): saturator temperature (T S ) of 353.2 K, CS concentration of the TPH-CS solution (C CS ) of 1 mg/ mL, and CO 2 to solution flow ratio of 1.8. The effect of CS/TPH mass ratios (Z = CS/TPH) used during the SAA process on TPH-CS composite particle size was examined over a range of 1−10, as shown in Table 1 (runs #1 to #5).…”

Section: Characterization Of Tph-cs Composite Particlesmentioning

confidence: 99%

“…The particle size of the SAA-processed material can be manipulated by changing the saturator temperature and concentration of the feed solution (Wu et al, 2015). Therefore, these factors were varied during SAA to prepare TPH-CS composite particles with different sizes but the same composition (Z = 5).…”

Section: Effects Of Mass Ratio and Composite Particle Size On Dissolumentioning

confidence: 99%

See 2 more Smart Citations

Controlled Release of Theophylline-Chitosan Composite Particles Prepared Using Supercritical Assisted Atomization

Chen

Lee

2019

Braz. J. Chem. Eng.

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This study investigated the formation of composite particles of chitosan (CS) and theophylline (TPH) via supercritical assisted atomization (SAA) using aqueous ethanol (50%, v/v) as the solvent and supercritical CO 2 as the spraying medium. According to XRD, DSC, and FTIR analyses, the crystal form of the SAA-treated TPH from the as-received TPH was unchanged. The effect of different mass ratios of CS to TPH on the in vitro release of TPH showed that the dissolution of the highly water-soluble TPH was retarded when included in the composite particles and could be controlled by the mass ratio of the component in the SAA process. The in vitro dissolution data showed a good fit with the Peppas-Sahlin model, which was used to conclude that the drug release from the composite particles resulted from a combination of drug diffusion and relaxation of the polymer. As the mass ratio of CS to TPH increased, the mechanism relating to polymer relaxation became crucial in the TPH-CS composite particles.

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Micronization of chitosan via rapid expansion of supercritical solution

Ghoreishi

Hedayati

Kordnejad

2016

The Journal of Supercritical Fluids

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Precipitation kinetics and biological properties of chitosan microparticles produced using supercritical assisted atomization

Cited by 7 publications

References 48 publications

Formation of Polyethylene Glycol Particles Using a Low-Temperature Supercritical Assisted Atomization Process

Formation of Polyethylene Glycol Particles Using a Low-Temperature Supercritical Assisted Atomization Process

Controlled Release of Theophylline-Chitosan Composite Particles Prepared Using Supercritical Assisted Atomization

Micronization of chitosan via rapid expansion of supercritical solution

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