Precipitation of thiopental with muscle relaxants: a potential hazard

The incidence, significance, and management of accidental intra-arterial injection: a narrative review

“…Two patients made a full recovery, and the third had residual finger-tip necrosis. 64 These results are consistent with those of Rohm et al, who used heparin in addition to four-hour cycles of intra-arterial 5 mg rt-PA alternating with PGE 1 5 lg. 60 Although difficult to prove with a limited number of case reports, it appears that prostaglandins may best be used in combination with thrombolytics.…”

“…The intravenous line became occluded and the cannula had to be re-positioned. 64 This reaction was thought to be the result of the large difference in pH between the two drugs (pH 10.5 and 4). Although the drugs did not crystallize in arterial circulation, this case highlights the potential complications of injecting different medications in close temporal proximity to one other.…”

Compatibility of common IV drugs with 6% hydroxyethyl starch 130/0.42 and 4% gelatin

“…For some drugs, pH is essential for its solubility in a fluid. Thiopental is best soluble in alkaline pH . The pH of infusion solutions is not steady, but may change due to binding CO 2 from the atmosphere, which is a time‐ and temperature‐dependent process.…”

Compatibility of common drugs with acetate‐containing balanced electrolyte solutions in pediatric anesthesia

“…to use several methods to detect incompatibility reactions . Thiopental is best soluble in alkalotic pH . Therefore, we cannot exclude incompatibility reactions to BS‐G1 and NS in mixture ratios other than 1 : 1.…”