Precise Design of Atomically Dispersed Fe, Pt Dinuclear Catalysts and Their Synergistic Application for Tumor Catalytic Therapy

Abstract

Recently, extending single-atom catalysts from mono- to binary sites has been proved to be a promising way to realize more efficient chemical catalytic processes. In this work, atomically dispersed Fe, Pt dinuclear catalysts ((Fe, Pt)SA-N-C) with an ca. 2.38 Å distance for Fe1 (Fe-N3) and Pt1 (Pt-N4) could be precisely controlled via a novel secondary-doping strategy. In response to tumor microenvironments, the Fe-N3/Pt-N4 moieties exhibited synergistic catalytic performance for tumor catalytic therapy. Due to its beneficial microstructure and abundant active sites, the Fe-N3 moiety effectively initiated the intratumoral Fenton-like reaction to release a large amount of toxic hydroxyl radicals (•OH), which further induced tumor cell apoptosis. Meanwhile, the bonded Pt-N4 moiety could also enhance the Fenton-like activity of the Fe-N3 moiety up to 128.8% by modulating the 3d electronic orbitals of isolated Fe-N3 sites. In addition, the existence of amorphous carbon revealed high photothermal conversion efficiency when exposed to an 808 nm laser, which synergistically achieved an effective oncotherapy outcome. Therefore, the as-obtained (Fe, Pt)SA-N-C-FA-PEG has promising potential in the bio-nanomedicine field for inhibiting tumor cell growth in vitro and in vivo.

Photo‐facilitated chemodynamic therapeutic agents: Synthesis, mechanisms, and biomedical applications

“…[49,50] Briefly to say, bimetal catalysis achieved synergistic effect with higher catalytic activity, realized synergistic treatment, and strengthened CDT effect. [51] Zheng's group synthesized a heteronuclear bimetallic single-atom catalyst ((Fe, Pt) SA-N-C) through a secondary doping strategy. Fe-N 3 /Pt-N 4 achieved precise control of the coordination structure and electronic structure of dual active sites and simultaneously exhibited a synergistic effect under TME.…”

“…Fe-N 3 /Pt-N 4 achieved precise control of the coordination structure and electronic structure of dual active sites and simultaneously exhibited a synergistic effect under TME. [51] Fe-N 3 had abundant active sites, which effectively elicited the Fenton reaction, released a significant amount of extremely cytotoxic •OH, and caused apoptosis in tumor cells. Meanwhile, the Pt single atom could enhance the Fenton activity of the Fe-N 3 site to 128.8% by modulating the 3d orbital of the Fe single atom, thereby effectively enhancing the catalytic chemotherapeutic effect.…”

A dual gate-controlled intelligent nanoreactor enables collaborative precise treatment for cancer nanotherapy

“…39 To evaluate the Fenton-like catalytic activity of the prepared nanoreactor, the colorless 3,3′,5,5′-tetramethylbenzidine (TMB) was applied as the chromogenic substrate, which could be oxidized to blue in the presence of ˙OH. 40,41 As depicted in Fig. 2a, negligible absorbance peaks appeared at 652 nm when there was only TMB or TMB + H 2 O 2 , illustrating that no ROS were produced.…”

Precisely designed Fex (x = 1–2) cluster nanocatalysts for effective nanocatalytic tumor therapy

“…1j), indicating the nature of isolated single atoms. 34 To further reveal the bonding structure, the coordination numbers (C.N.) and bond lengths (B.L.)…”

“…Among them, the Fe-N 3 part could initiate the intratumoral Fenton-like reaction, while the Pt-N 4 part could further synergistically improve the catalytic performance of Fe-N 3 sites by regulating the electron orbital. 34 However, the mild acidity ( pH 6.5-6.9) of the tumor region reduces the catalytic activity of Fenton reaction reagents, resulting in insufficient ROS production. 35,36 Hence, the development of efficient and safe nanomaterials with the GSH depletion ability and high Fenton catalytic activity is of great significance for nanocatalytic therapy.…”