Precise evaluation of liver histology by computerized morphometry shows that steatosis influences liver stiffness measured by transient elastography in chronic hepatitis C

Abstract

A precise evaluation of liver histology by computerized morphometry shows that liver stiffness measured by Fibroscan is linked to liver fibrosis, activity, and also steatosis. High level of steatosis induces misevaluation of liver fibrosis by Fibroscan.

Ultrasound Elastography: Review of Techniques and Clinical Applications

“…They found that 12.6% of F0/1 were misclassified as F2 when the steatosis area of the liver specimen (area of steatosis vesicles over complete liver surface estimated by morphometry) was < 4.0 %. When the steatosis area was ≥ 4%, the rate of misclassification rose to 32.4% 60. However, other studies suggested that presence of steatosis did not influence fibrosis estimation.…”

Transient Elastography (FibroScan) Is Not Correlated With Liver Fibrosis but With Cholestasis in Patients With Long‐Term Home Parenteral Nutrition

“…However, several factors may influence TE values in assessing the degree of fibrosis such as the presence of steatosis, 39 a standardized meal before TE, 40 , 41 and alcohol consumption 42 …”

Quantification of portal–bridging fibrosis area more accurately reflects fibrosis stage and liver stiffness than whole fibrosis or perisinusoidal fibrosis areas in chronic hepatitis C

“…4 Some studies also used image analysis of liver tissue to evaluate correlations between the proportion of whole collagen fibrosis and transient elastography. 27,[38][39][40] Wong et al 27 observed in an univariate analysis that 'pericellular fibrosis' better correlated with liver stiffness measurement than 'periportal' or 'perivenular fibrosis,' especially in patients with severe fibrosis. This study and ours are barely comparable, because of size difference and different methodology.…”