Precise magnetic resonance imaging-guided sonodynamic therapy for drug-resistant bacterial deep infection

Translation of Polymeric Microneedles for Treatment of Human Diseases: Recent Trends, Progress, and Challenges

“…If the skin is sensitive, it can lead to mild to medium inflammation or allergies, redness, pain, swelling, and itching may cause discomfort for the patient [ 233 ]. Although the pores formed by microns in comparison to the hypodermic needle are small, microbial penetration is also less serious [ 153 ], and the pores will take time to rescreen [ 234 ]. These pores must be immediately resealed the active drugs, or contamination will occur [ 235 ].…”

The promise of low-intensity ultrasound: A review on sonosensitizers and sonocatalysts by ultrasonic activation for bacterial killing

“…When the sonosensitizers were absorbed by cells, Pd@Pt promoted the decomposition of O 2 by endogenous H 2 O 2 to increase the production of endogenous ROS. Wang et al [53] modified porphyrin with the bacterial targeting peptide to improve the inactivation efficiency.…”

“… Types of sonosensitizers Names of the sonosensitizers Types of ROS Parameters of ultrasound Microorganism Processing time Highest inactivation efficiency a Ref. Porphyrin organic sonosensitizer Hematoporphyrin monomethyl ether (HMME) Not mentioned 1 MHz 100 Hz PRF 6 W/cm 2 30% cycle Staphylococcus aureus (S. aureus) (G + ) 30 min 95% [51] HMME Not mentioned 1 MHz 3 W/cm 2 Porphyromonas gingivalis (P. gingivalis) (G-) 10 min 99.997% b [52] Fe@ upconversion nanoparticles (UCNP)-HMME 1 O 2 2 W/cm 2 Methicillin-resistant S. aureus (MRSA) (G + ) Extended-spectrum β-lactamase (ESBL)-producing Escherichia coli (E. coli) (G-) 10 min 70% 60% [65] Polymer-peptide-porphyrin conjugate (PPPC) Not mentioned 1 MHz 1.5 W/cm 2 MRSA (G + ) 0–9 min 100% [53] Pd @ Pt-T790 Not mentioned 1 MHz 0.97 W/cm 2 50% cycle MRSA (G + ) 8 min 100% [29] Xanthones organic sonosensitizer Rose Bengal (RB) Not mentioned 28 kHz 0.84 W/cm 2 S. aureus (G + ) E. coli (G-) 1 h 99.999% 99.998% [55] RB Not mentioned 1 MHz 2.5 W/cm 2 Candida albicans (C. albicans) 5 min 100% [66] RB–antimicrobi...…”

Advances and Perspectives of Peptide and Polypeptide‐Based Materials for Biomedical Imaging

“…Recently, Wang and co‐workers reported a polymer–peptide–porphyrin conjugate for MRI‐guided sonodynamic therapy. [ 66 ] Here, peptide PLGVRG, KLVFF, CGGGTGRAKRRMQYNRR, and porphyrin conjugated CGGG were designed and synthesized for specific cleavage by gelatinase, in situ self‐assembly, bacteria‐targeting and Mn 2+ loading, respectively. These peptides were conjugated with polymer backbone and self‐assembled into nanoparticles.…”