2020
DOI: 10.1186/s12978-020-0874-7
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PRECISE pregnancy cohort: challenges and strategies in setting up a biorepository in sub-Saharan Africa

Abstract: Background and objective: PRECISE is a population-based, prospective pregnancy cohort study designed for deep phenotyping of pregnancies in women with placenta-related disorders, and in healthy controls. The PRECISE Network is recruiting~10,000 pregnant women in three countries (The Gambia, Kenya, and Mozambique) representing sub-Saharan Africa. The principal aim is to improve our understanding of pre-eclampsia, fetal growth restriction and stillbirth. This involves the creation of a highly curated bioreposito… Show more

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Cited by 11 publications
(9 citation statements)
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“…This is especially challenging for chemical exposome-microbiome research as repeated sampling of food and multiple biospecimens could be required from a single participant over a longer time period (e.g., in longitudinal sampling design). Cultural barriers may limit the collection of samples for research purposes [68]. In South Africa, 25 out of 200 participants expressed strong concerns and objection to export of their blood samples abroad, with some citing concerns about the use of their blood for rituals [69].…”
Section: Cultural Barriersmentioning
confidence: 99%
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“…This is especially challenging for chemical exposome-microbiome research as repeated sampling of food and multiple biospecimens could be required from a single participant over a longer time period (e.g., in longitudinal sampling design). Cultural barriers may limit the collection of samples for research purposes [68]. In South Africa, 25 out of 200 participants expressed strong concerns and objection to export of their blood samples abroad, with some citing concerns about the use of their blood for rituals [69].…”
Section: Cultural Barriersmentioning
confidence: 99%
“…Moreover, the atmosphere of mistrust that exists in some African communities [72] could be linked to past research misconduct by a few western researchers [73], which further compounds the problem of biological sample collection. The situation becomes more complicated when samples are to be collected from NITs, or participants are to be recruited during pregnancy [68]. Pregnant women are sometimes very critical and may express superstitious fear of harm to the unborn child.…”
Section: Cultural Barriersmentioning
confidence: 99%
See 1 more Smart Citation
“…A major legacy of the PRECISE programme will be the establishment of combined pregnancy multidimensional databases and biorepositories in Kenya, The Gambia and Mozambique [11,12]. The combination of biological samples and extensive phenotypic data will enable new research into the biological pathways and co-exposures that cause, confound and affect the impact of placental disease (i.e., pre-eclampsia, fetal growth restriction, preterm birth and stillbirth) in sub-Saharan Africa.…”
Section: Programme Level Capacity Building In Global Research Activitiesmentioning
confidence: 99%
“…1) is funded by the UKRI GCRF GROW call which had the specific aim of developing "research capacity around the globe and to strengthen and broaden skills and expertise to address specific challenges of developing regions and countries" [1]. As is shown by the first four papers in this BMC Reproductive Health Supplement, An Introduction to The PRECISE Network [10][11][12][13], this programme of work aims to achieve capacity building through the development of an international team that will set-up a pregnancy biobank and develop a holistic data set to enable deep phenotyping of factors affecting placental disease in three sub-Saharan African settings. This is summarised in the first of the four PRECISE Network aims, "Build individual and institutional research capacity across Africa and the UK through a shared pregnancy research programme of work" [14].…”
Section: Introductionmentioning
confidence: 99%