Precision Errors, Least Significant Change, and Monitoring Time Interval in Pediatric Measurements of Bone Mineral Density, Body Composition, and Mechanostat Parameters by GE Lunar Prodigy

Jaworski, Maciej; Płudowski, Paweł

doi:10.1016/j.jocd.2013.01.003

Cited by 13 publications

(8 citation statements)

References 13 publications

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“…The same DXA device and software were used for all measurements. DXA provides valid and reliable data on BMC and body composition in children (coefficient of variation = 0.01 – 4.37%) ( 25 ). A quality assurance test was performed daily prior to patient measurements.…”

Section: Methodsmentioning

confidence: 99%

The Mediating Role of Endocrine Factors in the Positive Relationship Between Fat Mass and Bone Mineral Content in Children Aged 9–11 Years: The Physical Activity and Nutrition in Children Study

et al. 2022

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IntroductionWe aimed to investigate whether the relationship between fat mass and bone mineral content (BMC) is mediated by insulin, leptin, adiponectin, dehydroepiandrosterone sulphate, testosterone and estradiol in children aged 9-11 years.Materials and MethodsWe utilised cross-sectional data from the Physical Activity and Nutrition in Children study (n = 230 to 396; 112 to 203 girls). Fat mass and BMC were assessed with dual-energy X-ray absorptiometry. Endocrine factors were assessed from fasted blood samples. We applied the novel 4-way decomposition method to analyse associations between fat mass, endocrine factors, and BMC.ResultsFat mass was positively associated with BMC in girls (ß = 0.007 to 0.015, 95% confidence interval (CI) 0.005 to 0.020) and boys (ß = 0.009 to 0.015, 95% CI 0.005 to 0.019). The relationship between fat mass and BMC was mediated by free leptin index in girls (ß = -0.025, 95% CI -0.039 to -0.010) and boys (ß = -0.014, 95% CI -0.027 to -0.001). The relationship between fat mass and BMC was partially explained by mediated interaction between fat mass and free leptin index in boys (ß = -0.009, 95% CI -0.013 to -0.004) and by interaction between fat mass and adiponectin in girls (ß = -0.003, 95% CI -0.006 to -0.000).ConclusionAt greater levels of adiponectin and free leptin index, the fat mass and BMC relationship becomes less positive in girls and boys respectively. The positive association between fat mass with BMC was largely not explained by the endocrine factors we assessed.Clinical Trial Registration[https://clinicaltrials.gov/ct2/show/NCT01803776], identifier NCT01803776.

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Section: Methodsmentioning

confidence: 99%

The Mediating Role of Endocrine Factors in the Positive Relationship Between Fat Mass and Bone Mineral Content in Children Aged 9–11 Years: The Physical Activity and Nutrition in Children Study

et al. 2022

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“…The same DXA device and software were used for all measurements. DXA provides valid and reliable data on BMC and body composition in children (coefficient of variation = 0.01–4.37%) [ 17 , 18 ]. A quality assurance test was performed daily prior to patient measurements.…”

Section: Methodsmentioning

confidence: 99%

The Positive Relationship between Moderate-to-Vigorous Physical Activity and Bone Mineral Content Is Not Mediated by Free Leptin Index in Prepubertal Children: The PANIC Study

Constable

Porter

Benger

et al. 2021

IJERPH

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Purpose: Moderate-to-vigorous physical activity (MVPA) positively influences bone mineral content (BMC) in prepubertal children, but it is unknown whether this relationship is partially mediated by free leptin index. The aim of this study was to examine whether the relationship between MVPA and total body less head (TBLH) BMC is mediated or moderated by free leptin index in prepubertal children. Methods: We performed a cross-sectional analysis on 401 children (194 girls) from baseline examinations of the Physical Activity and Nutrition in Childhood Study. We applied the four-way decomposition mediation analysis method to assess whether free leptin index, measured from fasted blood samples, mediated the relationship between accelerometer-measured MVPA and TBLH BMC measured by dual-energy X-ray absorptiometry. Results: MVPA had a positive controlled direct effect on TBLH BMC in girls and boys (β = 0.010 to 0.011, p < 0.05). There was no mediation or interaction between MVPA, free leptin index and TBLH BMC in girls or boys (β = −0.000 to 0.001, p > 0.05). Conclusion: Our study indicates that MVPA positively influences TBLH BMC through pathways not related to free leptin index in predominantly normal-weight prepubertal children, likely primarily through mechanical loading. The relationships between MVPA, free leptin index and TBLH BMC may be influenced by other factors such as pubertal status and adiposity, so it is unknown whether these observations extend to overweight and obese children at different stages of puberty.

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“…Precision for LS‐aBMD in children was reported in literature with 0.31% coefficient of variation. ( 42 ) Three trained examiners with long‐time experience conducted the measurements. Clothing of the patients and positioning on the device were executed as instructed by the manufacturer.…”

Section: Methodsmentioning

confidence: 99%

Bone Microarchitecture Assessed by Trabecular Bone Score Is Independent of Mobility Level or Height in Pediatric Patients with Cerebral Palsy

Rehberg

Azim

Martakis

et al. 2020

Journal of Bone and Mineral Research

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Bone strength and fracture risk do not only depend on bone density, but also on bone structure. The trabecular bone score (TBS) evaluates homogeneity of bone microarchitecture indirectly by measuring gray‐level variations of two‐dimensional (2D) DXA images. Although TBS is well‐established for adults, there have been only few publications in pediatrics. In this monocentric retrospective analysis, we investigated TBS in children and adolescents with cerebral palsy (CP), a patient group vulnerable to low bone mineral mass due to impaired mobility. The influence of different parameters on TBS and areal BMD (aBMD) were evaluated, as well as the relationship between TBS and aBMD. We compared TBS values of our study population to a reference population. A total of 472 lumbar spine–dual‐energy X‐ray absorptiometry (LS‐DXA) scans of children and adolescents with CP (205 female), aged between 4 and 18 years, were analyzed. The DXA‐scans were part of the routine examination. The children had no records of fractures or specific bone diseases. Our study population with CP had similar TBS as the reference population. TBS did not increase with age until an inflection point at 10 years in females, and 12 years in males. Girls had significantly higher TBS than boys (p = .049) and pubertal girls aged 8 to 13 years had significantly higher TBS than prepubertal girls (p = .009). TBS standard deviation score for age (SDS‐TBS) and aBMD Z‐scores correlated weakly (p < .001; R = 0.276 [males], R = 0.284 [females]). Other than for aBMD Z‐scores, SDS‐TBS was not influenced by age‐adjusted height Z‐scores and there was no significant difference in SDS‐TBS when grouped by mobility levels, using the Gross Motor Function Classification System (GMFCS). Our results indicate that children with CP have a similar homogeneous distribution of trabecular microarchitecture as controls. Puberty initiation appears to be essential for increase of TBS with age and for sex differences. TBS seems less influenced by body composition, height, and mobility than aBMD. © 2020 The Authors. Journal of Bone and Mineral Research published by American Society for Bone and Mineral Research.

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Precision Errors, Least Significant Change, and Monitoring Time Interval in Pediatric Measurements of Bone Mineral Density, Body Composition, and Mechanostat Parameters by GE Lunar Prodigy

Cited by 13 publications

References 13 publications

The Mediating Role of Endocrine Factors in the Positive Relationship Between Fat Mass and Bone Mineral Content in Children Aged 9–11 Years: The Physical Activity and Nutrition in Children Study

The Mediating Role of Endocrine Factors in the Positive Relationship Between Fat Mass and Bone Mineral Content in Children Aged 9–11 Years: The Physical Activity and Nutrition in Children Study

The Positive Relationship between Moderate-to-Vigorous Physical Activity and Bone Mineral Content Is Not Mediated by Free Leptin Index in Prepubertal Children: The PANIC Study

Bone Microarchitecture Assessed by Trabecular Bone Score Is Independent of Mobility Level or Height in Pediatric Patients with Cerebral Palsy

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