One of the primary global objectives is to decrease building energy consumption to promote energy efficiency and environmental sustainability. The large-scale food retail trade sector accounts for over 15% of total primary energy consumption in Europe, posing a significant challenge to the transition towards green energy. This study proposes a simple method for energy efficiency, environmental sustainability, and cost-saving assessment and improvement in large-scale food retail trade buildings. It aims to analyze the energy and environmental performance of building–plant systems, establishing an interactive network to assess intervention potential for the energy transition. The investigation focuses on the proper selection and analysis of the benefits of retrofit solution implementation, emphasizing potential energy savings in current and future climate change scenarios. Dynamic simulation with the Building Energy Model (BEM) was used to evaluate the impacts of building–plant system retrofit solutions, such as high thermal insulation, photovoltaic (PV) panels, Light Emitting Diode (LED) installation, waste heat recovery, and improvement in refrigeration units. The results show a reduction in annual energy consumption for the PV panel installation by up to 29% and lighting systems with high-quality LED to 60%. Additionally, CO2 emissions can be decreased by up to 41% by combining these two strategies.