Micro integral impeller is the key component of micro aero-engine, and its machining quality will directly affect the performance of micro-engine. Aiming at the narrow flow path of the tiny integral blade, the large distortion of the blade and the large ratio of free-form surface and divided into main and double blades, the five-axis NC machining method of the micro-integral impeller is studied in this paper. The research on the five-axis NC machining method of the microintegrated impeller is carried out. Firstly, according to the structural characteristics of the micro integral impeller, the NC programming is carried out in Siemens NX software, and the obtained tool path is verified by 2D dynamic simulation and 3D dynamic simulation. Finally, the micro integral impeller is obtained through the milling test. There are no interference, overcutting, undercutting and other problems in the machining process. Thus, the correctness of the machining technology and machining method is verified.