Preclinical evaluation of nephroprotective potential of a probiotic formulation LOBUN on Cyclosporine-A induced renal dysfunction in Wistar rats

Venkateswarlu, K.; Heerasingh, Thakur; Babu, Chilamakuru Naresh; Triveni, S.; Manasa, Suroju; Babu, Thumati Nagendra Bhaskar

doi:10.1590/s2175-97902017000216041

Cited by 6 publications

(2 citation statements)

References 16 publications

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“…Doramectin (Dectomax ® ) is a semisynthetic avermectin, and when administered repetitively, it can diffuse to tissues and contribute to mild toxicity, hepatic toxicity, renal toxicity, and central nervous system depression ( Zhang et al , 2016 ). Usually, it can be deposited in adipose tissue, interfere with hepatocellular activity causing lipid peroxidation and degradation, and suppress the glutathione enzymatic system activity, contributing to the suppression of proliferating cell nuclear antigen ( Venkateswarlu et al , 2017 ). That is why the use of such synthetic insecticides should not be repeated without cause.…”

Section: Discussionmentioning

confidence: 99%

The in-vivo and in-vitro Effectiveness of Three Insecticides Types for Eradication of The Tick Rhipicephalus sanguineus in Dogs

Aboelela¹,

Sobieh²,

Abouelhassan³

et al. 2022

Open Vet J

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Background: External parasites contribute to extensive harmful impacts on their hosts which is why control and eradication of external parasites have been included in all biosecurity plans of dog houses. Aim: To evaluate the in-vitro and in-vivo effectiveness of chemicals like Doramectin injectable and Fipronil 50 mg/ml drops and herbal mixes eco-friendly insecticides like phenylpyrazole–garlic–camphor mix spray for combating the external parasitism in dogs and their influence on the hematological, biochemical, and cortisol (CORT) profiles. Method: The in-vitro effectiveness of the insecticides was conducted by using a total of 216 developmental stage Rhipicephalus sanguineus (72 adults, 72 larvae, and 72 eggs) designed into three replicates of petri dishes (3 plates × 8 units × 3 stages/replicate); each replicate was exposed to 1 ml insecticide. The number of surviving ticks was recorded after 0, 2, 4, 8, 16, and 24 hours. Sixteen Rottweiler male dogs aged 1 year and 45.5 kg were divided into four groups. Three groups (G1, G2, and G3) were experimentally infested with R. sanguineus ticks 3–4 weeks post-dog arrival and kept under observation from zero-time of experimental infestation for 1–2 weeks. The three experimentally infested dog groups were treated with Doramectin injectable, Fipronil 50 mg/ml drops, and phenylpyrazole–garlic–camphor mix spray, respectively, and the fourth group was designed as a negative control. A total of 144 samples, including 48 ethylenediaminetetraacetic acid blood, 48 whole blood, and 48 sera samples, were collected. Results: The in-vitro efficacy revealed highly significant ( p < 0.01) 100% killing efficacy that was achieved after 8 hours in Doramectin and Fipronil 50 mg/ml and 24 hours in phenylpyrazole–garlic–camphor mix. The in-vivo trials revealed highly significant ( p < 0.01) improvements of red blood cells, hematocrit, mean corpuscular hemoglobin concentrations, platelets, total and differential leukocytic counts, erythrocyte sedimentation rates in the second hour, total protein, creatinine, alanine aminotransferase, urea, glucose, triglycerides, total cholesterol, and CORT levels in the 2-week (P 1 ) and 4-week posttreatment (P 2 ) samples in Dormectin, Fipronil 50 mg/ml, and phenylpyrazole–garlic–camphor mix-treated dogs with more pronounced recovery in phenylpyrazole–garlic–camphor mix spray-treated dogs. Conclusion: The insecticides were able to provide a high level of protection against experimental infestation with concern to the different modes of application. Phenylpyrazole–garlic–camphor mix spray (eco-friendly) achieved higher insecticidal act...

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Section: Discussionmentioning

confidence: 99%

The in-vivo and in-vitro Effectiveness of Three Insecticides Types for Eradication of The Tick Rhipicephalus sanguineus in Dogs

Aboelela¹,

Sobieh²,

Abouelhassan³

et al. 2022

Open Vet J

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“…The analysis of the basic and classic biochemical parameters used to evaluate renal function showed significant alterations in the group of rats supplemented with probiotics, prebiotics, and symbiotics in the diet and chronically exposed to cigarette smoke. This reduction in harmful effects may be due to the beneficial modulation of these functional foods in bacterial growth in the colon, increasing the concentration of saccharolytic microorganisms and decreasing the concentration of proteolytic species, resulting in a reduction in the generation of toxins harmful to the kidney (Venkateswarlu et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Probiotics, prebiotics and symbiotics attenuate chronic effects of passive smoking on physiological and biochemical parameters in rats: A randomized and controlled study

Rombi

Lopes

Ortiz

et al. 2021

RSD

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Passive and chronic exposure to tobacco smoke is a major cause of preventable diseases in humans and animals. The aim of this study was to evaluate the physiological and biochemical effects of functional foods: probiotics, prebiotics, and symbiotics in young rats exposed chronically to cigarette smoke. Ninety-six young male rats were randomly assigned to eight groups (n = 12): control (C); probiotic (Pro); prebiotic (Pre); symbiotic (Sym); smoking control (CS); smoking probiotic (ProbS); smoking prebiotic (PrebS); and smoking symbiotic (SymbS). After the experimental period of 189 days, the animals were anesthetized, blood samples were collected, and the animals were euthanized by exsanguination. The data were submitted to the Shapiro Wilk test, followed by the one-way ANOVA test, with contrasts by the Tukey method (P<0.05). The results demonstrated that chronic passive exposure to cigarette smoke had deleterious effects on the animals, and that these effects were attenuated in groups of animals supplemented with functional foods. In the supplemented groups there were significant improvements in weight gain, and mean values of liver enzymes (ALT, AST, GGT, and ALP), serum proteins (albumin and globulins), blood glucose, uremia, and creatininemia. We conclude that functional foods, probiotics, prebiotics, and symbiotics, attenuate the deleterious effects on the physiological and biochemical parameters of rats chronically exposed to cigarette smoke.

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Vitamin E and selenium administration synergistically mitigates ivermectin and doramectin-induced testicular dysfunction in male Wistar albino rats

Ahmed

Alshehri

Alkahtani

et al. 2020

Biomedicine & Pharmacotherapy

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Preclinical evaluation of nephroprotective potential of a probiotic formulation LOBUN on Cyclosporine-A induced renal dysfunction in Wistar rats

Cited by 6 publications

References 16 publications

The in-vivo and in-vitro Effectiveness of Three Insecticides Types for Eradication of The Tick Rhipicephalus sanguineus in Dogs

The in-vivo and in-vitro Effectiveness of Three Insecticides Types for Eradication of The Tick Rhipicephalus sanguineus in Dogs

Probiotics, prebiotics and symbiotics attenuate chronic effects of passive smoking on physiological and biochemical parameters in rats: A randomized and controlled study

Vitamin E and selenium administration synergistically mitigates ivermectin and doramectin-induced testicular dysfunction in male Wistar albino rats

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