Preclinical Evidence for the Pharmacological Actions of Glycyrrhizic Acid: A Comprehensive Review

Rehman, Muneeb U.; Farooq, Adil; Ali, Rayeesa; Bashir, Sana; Bashir, Nazirah; Majeed, S.H.; Taifa, Syed; Ahmad, Sheikh Bilal; Arafah, Azher; Sameer, Aga Syed; Khan, Rehan; Qamar, Wajhul; Rasool, Saiema; Ahmad, Anas

doi:10.2174/1389200221666200620204914

Cited by 23 publications

(11 citation statements)

References 228 publications

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“…Research shows that the Ginsenoside Rg1 improved pathological damage in the ovary and uterus by increasing anti-oxidant and anti-inflammatory abilities whilst reducing the expression of senescence signaling pathways in POI (premature ovarian insufficiency) mouse models. Meanwhile, Glycyrrhizin possesses anti-inflammatory activity; hence, it is mostly used in traditional herbal medicine for the treatment and management of chronic diseases [ 21 ]. To sum up, quality control research on ingredients that may exert medicinal effects can better ensure the effectiveness and stability of the preparation.…”

Section: Resultsmentioning

confidence: 99%

Development and Validation of a UPLC-MS/MS Method for the Quantification of Components in the Ancient Classical Chinese Medicine Formula of Guyinjian

Yang

et al. 2022

Molecules

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Guyinjian (GYJ) is an ancient classic formula of traditional Chinese medicine used for the treatment of liver and kidney yin deficiency; it was derived from the book “Jing Yue Quan Shu” in the Ming Dynasty. Modern clinical observation experiments have shown that GYJ has a definite therapeutic effect on the treatment of gynecological diseases such as kidney deficiency type oligomenorrhea, climacteric syndrome, intermenstrual bleeding, pubertal metrorrhagia, etc. However, the lack of GYJ quality control studies has greatly limited the development of its wider clinical application. In this study, a validated UPLC-MS/MS method was developed successfully for the first time and used to quantify fourteen compounds in GYJ samples with good specificity, linearity (r = 0.9960−0.9999), precision (RSD% ≤ 3.18%), stability (RSD% ≤ 2.22%) and accuracy (recovery test within 88.64–107.43%, RSD% at 2.82–6.22%). Simultaneously, the determination results of 15 batches of GYJ samples were analyzed by multivariate statistical methods, and it was found that the compounds have a greater influence on batch-to-batch stability, mainly Rehmannioside D, Loganin, Morroniside, Ginsenoside Re, and 3′,6-Disinapoylsucrose. The proposed new method has the advantages of high sensitivity, high selectivity, and rapid analysis, which provides a reference for the GYJ quality control study.

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Section: Resultsmentioning

confidence: 99%

Development and Validation of a UPLC-MS/MS Method for the Quantification of Components in the Ancient Classical Chinese Medicine Formula of Guyinjian

Yang

et al. 2022

Molecules

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“…It can overcome the shortcomings of the current mainstream therapeutic strategies (corticosteroids and TCZ) against CRS. Glycyrrhizin can inhibit almost all factors responsible for inflammatory reactions (Rehman et al, 2020). This is a decisive advantage over alternative strategies in CRS management, including those that can only block or neutralize IL-1, IL-6, and GM-CSF.…”

Section: Discussionmentioning

confidence: 99%

“…Glycyrrhizin has been used in China for more than 4,000 years. It is widely employed to treat a variety of diseases and conditions because it possesses multiple pharmacological properties, including anti-inflammation, antioxidative, immunomodulatory, antiviral, anticancer, and hepatoprotective effects (Chen et al, 2020;Rehman et al, 2020;Bakr et al, 2022).…”

Section: Glycyrrhizin and Its Potential Advantages In The Treatment O...mentioning

confidence: 99%

Glycyrrhizin for treatment of CRS caused by CAR T-cell therapy: A pharmacological perspective

Li²,

Luo³

2023

Front. Pharmacol.

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Chimeric antigen receptor T (CAR T)-cell therapy promises to revolutionize the management of hematologic malignancies and possibly other tumors. However, the main side effect of cytokine release syndrome (CRS) is a great challenge for its clinical application. Currently, treatment of CRS caused by CAR T-cell therapy is limited to tocilizumab (TCZ) and corticosteroids in clinical guidelines. However, the theoretical risks of these two agents may curb clinicians’ enthusiasm for their application, and the optimal treatment is still debated. CAR T-cell therapy induced-CRS treatment is a current research focus. Glycyrrhizin, which has diverse pharmacological effects, good tolerance, and affordability, is an ideal therapeutic alternative for CRS. It can also overcome the shortcoming of TCZ and corticosteroids. In this brief article, we discuss the therapeutic potential of glycyrrhizin for treating CRS caused by CAR T-cell therapy from the perspective of its pharmacological action.

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“…It is also used for spleen‐stomach weakness, fatigue, lack of strength, palpitations, shortness of breath, cough and profuse sputum, painful spasm (stomach duct, abdomen and limbs), swelling abscess, and reducing the toxin and drastic action of other drugs. (Commission, 2020; Chen, Yang, et al, 2020; Chen, Cao, et al, 2019; Fiore et al, 2005; Gao et al, 2019; Gou et al, 2021; Harding & Stebbing, 2017; Jung et al, 2016; Li, Sun, & Liu, 2019; Maria Pia et al, 2019; Nugroho et al, 2016; Rehman et al, 2020; van Uum, 2005; C. Wang et al, 2020; R. Yang et al, 2015). It has been extensively applied in classical prescriptions.…”

Section: Novel Indications and Relevant Mechanisms Of Glycyrrhizae Ra...mentioning

confidence: 99%

Glycyrrhizae Radix et Rhizoma: The popular occurrence of herbal medicine applied in classical prescriptions

Kang

Zhang

et al. 2023

Phytotherapy Research

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Glycyrrhizae Radix et Rhizoma is a well-known herbal medicine with a wide range of pharmacological functions that has been used throughout Chinese history. This review presents a comprehensive introduction to this herb and its classical prescriptions. The article discusses the resources and distribution of species, methods of authentication and determination chemical composition, quality control of the original plants and herbal medicines, dosages use, common classical prescriptions, indications, and relevant mechanisms of the active content. Pharmacokinetic parameters, toxicity tests, clinical trials, and patent applications are discussed. The review will provide a good starting point for the research and development of classical prescriptions to develop herbal medicines for clinical use.

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Preclinical Evidence for the Pharmacological Actions of Glycyrrhizic Acid: A Comprehensive Review

Cited by 23 publications

References 228 publications

Development and Validation of a UPLC-MS/MS Method for the Quantification of Components in the Ancient Classical Chinese Medicine Formula of Guyinjian

Development and Validation of a UPLC-MS/MS Method for the Quantification of Components in the Ancient Classical Chinese Medicine Formula of Guyinjian

Glycyrrhizin for treatment of CRS caused by CAR T-cell therapy: A pharmacological perspective

Glycyrrhizae Radix et Rhizoma: The popular occurrence of herbal medicine applied in classical prescriptions

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