Preconception lifestyle advice for people with infertility

Boedt, Tessy; Vanhove, Anne-Catherine; Vercoe, M.; Matthys, Christophe; Dancet, Eline; Fong, Sharon Lie

doi:10.1002/14651858.cd008189.pub3

Cited by 22 publications

(23 citation statements)

References 213 publications

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“…Although not all infertile couples use ART as a treatment ( Te Velde et al , 2017 ), those who have used ART can be regarded as infertile. Previous literature has reported various risk factors for infertility in women ( Gaskins and Chavarro, 2018 ; Boedt et al , 2021 ; Hernaez et al , 2021 ) and men ( Jungwirth et al , 2013 ), such as obesity, diet, smoking, alcohol intake and aging. Among these, the effect of aging on infertility is of particular interest because a growing number of couples postpone their first childbirth to their 30s ( Baird et al , 2005 ; Nabukera et al , 2006 ).…”

Section: Introductionmentioning

confidence: 99%

Associations between epigenetic age acceleration and infertility

et al. 2022

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STUDY QUESTION Is the use of ART, a proxy for infertility, associated with epigenetic age acceleration? SUMMARY ANSWER The epigenetic age acceleration measured by Dunedin Pace of Aging methylation (DunedinPoAm) differed significantly between non-ART and ART mothers. WHAT IS KNOWN ALREADY Among mothers who used ART, epigenetic age acceleration may be associated with low oocyte yield and poor ovarian response. However, the difference in epigenetic age acceleration between non-ART and ART mothers (or even fathers) has not been examined. STUDY DESIGN, SIZE, DURATION The Norwegian Mother, Father and Child Cohort Study (MoBa) recruited pregnant women and their partners across Norway at around 18 gestational weeks between 1999 and 2008. Approximately 95 000 mothers, 75 000 fathers and 114 000 children were included. Peripheral blood samples were taken from mothers and fathers at ultrasound appointments or from mothers at childbirth, and umbilical cord blood samples were collected from the newborns at birth. PARTICIPANTS/MATERIALS, SETTING, METHODS Among the MoBa participants, we selected 1000 couples who conceived by coitus and 894 couples who conceived by IVF (n = 525) or ICSI (n = 369). We measured their DNA methylation (DNAm) levels using the Illumina MethylationEPIC array and calculated epigenetic age acceleration. A linear mixed model was used to examine the differences in five different epigenetic age accelerations between non-ART and ART parents. MAIN RESULTS AND THE ROLE OF CHANCE We found a significant difference in the epigenetic age acceleration calculated by DunedinPoAm between IVF and non-ART mothers (0.021 years, P-value = 2.89E−06) after adjustment for potential confounders. Further, we detected elevated DunedinPoAm in mothers with tubal factor infertility (0.030 years, P-value = 1.34E−05), ovulation factor (0.023 years, P-value = 0.0018) and unexplained infertility (0.023 years, P-value = 1.39E−04) compared with non-ART mothers. No differences in epigenetic age accelerations between non-ART and ICSI fathers were found. DunedinPoAm also showed stronger associations with smoking, education and parity than the other four epigenetic age accelerations. LIMITATIONS, REASONS FOR CAUTION We were not able to determine the directionality of the causal pathway between the epigenetic age accelerations and infertility. Since parents’ peripheral blood samples were collected after conception, we cannot rule out the possibility that the epigenetic profile of ART mothers was influenced by the ART treatment. Hence, the results should be interpreted with caution, and our results might not be generalizable to non-pregnant women. WIDER IMPLICATIONS OF THE FINDINGS A plausible biological mechanism behind the reported association is that IVF mothers could be closer to menopause than non-ART mothers. The pace of decline of the ovarian reserve that eventually leads to menopause varies between females yet, in general, accelerates after the age of 30, and some studies show an increased risk of infertility in females with low ovarian reserve. STUDY FUNDING/COMPETING INTEREST(S) This study was partly funded by the Research Council of Norway (Women’s fertility, project no. 320656) and through its Centres of Excellence Funding Scheme (project no. 262700). M.C.M. has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement number 947684). The authors declare no conflict of interest. TRIAL REGISTRATION NUMBER N/A.

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Section: Introductionmentioning

confidence: 99%

Associations between epigenetic age acceleration and infertility

et al. 2022

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“…Lifestyle factors can affect the likelihood of infertility [2]. Therefore, healthcare professionals should be more proactive in making lifestyle recommendations for infertility patients [11].…”

Section: Effect Of Lifestyle Interventions For Adults With Infertilitymentioning

confidence: 99%

“…Infertility is growing rapidly worldwide and has become a pervasive problem with significant consequences for individuals, families, and communities [1,2]. In many cultures, infertility is stigmatized [3].…”

Section: Introductionmentioning

confidence: 99%

Lifestyle Interventions for Adults with Infertility

Kim

Nho

2022

JLM

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With a significant increase in the age-standardized prevalence of infertile men and women, infertility has become a widespread global issue. Furthermore, infertility has led to increased stigma and disease burden. The causes of infertility include lifestyle factors such as obesity, an unbalanced diet, and physical activity. To increase the rate of successful pregnancy, infertile men and women must improve their health and fertility through lifestyle improvements.

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“…[9][10][11] Modifiable risks are often related to health behaviors such as poor diet, substance use and exposure to toxins. 12 Evidence suggests many people are unaware of the degree to which their preconception health can affect fertility, pregnancy, and future health outcomes. 11 Preconception health is relevant to all people because of its positive impact on an individual's short-and long-term health regardless of pregnancies.…”

Section: Background Preconception Healthmentioning

confidence: 99%

Setting Preconception Care Priorities in Australia Using a Delphi Technique

et al. 2022

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Preconception health affects fertility, pregnancy, and future health outcomes but public awareness of this is low. Our aims were to rank priorities for preconception care (PCC), develop strategies to address these priorities, and establish values to guide future work in preconception healthcare in Australia. A Delphi technique involved two rounds of online voting and mid-round workshops. Inputs were a scoping review of PCC guidelines, a priority setting framework and existing networks that focus on health. During July and August, 2021, 23 multidisciplinary experts in PCC or social care, including a consumer advocate, completed the Delphi technique. Ten priority areas were identified, with health behaviors, medical history, weight, and reproductive health ranked most highly. Six strategies were identified. Underpinning values encompassed engagement with stakeholders, a life course view of preconception health, an integrated multi-sectorial approach and a need for large scale collaboration to implement interventions that deliver impact across health care, social care, policy and population health. Priority populations were considered within the social determinants of health. Health behaviors, medical history, weight, and reproductive health were ranked highly as PCC priorities. Key strategies to address priorities should be implemented with consideration of values that improve the preconception health of all Australians.

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Preconception lifestyle advice for people with infertility

Cited by 22 publications

References 213 publications

Associations between epigenetic age acceleration and infertility

Associations between epigenetic age acceleration and infertility

Lifestyle Interventions for Adults with Infertility

Setting Preconception Care Priorities in Australia Using a Delphi Technique

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