Objective-This study describes the timing and correlates of folic acid supplement intake among pregnant women.Study design-Data from 2518 women with estimated delivery dates from 1997 to 2000, collected for the National Birth Defects Prevention Study, a population-based case-control study, were analyzed. Multinomial logistic regression was used to identify correlates of supplement intake.Results-Fifty-three percent of women began taking folic acid supplement during the periconceptional period, 35% during early pregnancy, and 8% during late pregnancy (ie, 3 months before through 1 month after conception, 2-3 months after conception, or more than 3 months after conception, respectively). Women who did not take folic acid supplement periconccptionally tended to be nonwhite, speak Spanish, have low education, be younger than 25 years old. be nulliparous, smoke, have no previous miscarriage and no fertility treatments, begin prenatal care and become aware of their pregnancy after the first trimester, have nonplanned pregnancies, and eat less breakfast cereal.Conclusion-This study identifies correlates of folic acid supplement intake, which may contribute to the design of interventions to improve intake during early pregnancy.
Keywords
Folic acid; Supplements; PregnancyThe Public Health Service and the Institute of Medicine recommend that women of childbearing age consume at least 400 μg/day of synthetic folic acid (FA), 1,2 an amount that is present in most multivitamin/ mineral supplements. The recommendation was originally intended to prevent neural tube defects. FA also may prevent other birth defects, 3-7 other adverse reproductive outcomes, 8 and chronic diseases. 8 Taking FA-containing supplements remains the most likely route of meeting the recommended intake level, even after considering folate intake from fortified foods. 9,10 By the end of pregnancy, most women are taking FA
NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript supplements, 11 but in the first few weeks, before pregnancy is clinically evident, closer to one third of women take supplements daily. 4,11-14 Intake during early pregnancy is critical because most birth defects occur during the first few weeks of pregnancy. For example, neural tube closure is completed by day 28 after conception, or 6 weeks after the last menstrual period.Information on patterns of FA supplement intake during pregnancy and correlates of this behavior is critical to the design of effective interventions to improve intake. Few studies have examined correlates of supplement intake during pregnancy in relatively large and diverse study populations and included multivariable analysis. 11,15,16 We are aware of only 1 study that examined whether predictors of supplement intake varied as pregnancy progressed, and its data are from births that occurred in 1988, before the issuance of major public health recommendations regarding FA. 11 This study describes the pattern of intake of FA supplements among pregnant women and examines correlates of F...