Prediagnostic circulating carotenoid levels and the risk of non-Hodgkin lymphoma: the Multiethnic Cohort

Ollberding, Nicholas J.; Maskarinec, Gertraud; Conroy, Shannon M.; Morimoto, Yukiko; Franke, Adrian A.; Cooney, Robert V.; Wilkens, Lynne R.; Marchand, Loı̈c Le; Goodman, Marc T.; Hernandez, Brenda Y.; Henderson, Brian E.; Kolonel, Laurence N.

doi:10.1182/blood-2012-02-413609

Cited by 18 publications

(16 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…On the other hand, a reduced risk has been reported with higher intakes of dietary fiber, whole grain foods and several fruits and vegetables. This has been attributed primarily to the presence of biologically active phytochemicals and antioxidant nutrients, which have the ability to quench free radicals and inhibit nitrosation reactions (Frankenfeld.et al, 2008;Thompson et al, 2010;Holtan et al, 2011;Ollberding et al, 2012).…”

mentioning

confidence: 99%

Dietary and Lifestyle Factors and Risk of Non-Hodgkin's Lymphoma in Oman

Ali

Al-Belushi

Waly

et al. 2013

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

mentioning

confidence: 99%

Dietary and Lifestyle Factors and Risk of Non-Hodgkin's Lymphoma in Oman

Ali

Al-Belushi

Waly

et al. 2013

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

“…Además, existen reportes que evidencian un ligero incremento de riesgo de sufrir LNH en individuos que consumen tabaco [19,20]. Por otro lado, una dieta rica en compuestos antioxidantes, reduce la probabilidad de desarrollar la enfermedad [21,22].…”

Section: Estadio IVunclassified

Estudio Descriptivo: Características Clínicas, Demográficas E Histopatológicas De Pacientes Con Diagnóstico De Linfoma No Hodgkin.

Freire¹,

Calderón²,

Proaño

et al. 2015

Rev Med HJCA

View full text Add to dashboard Cite

230 RESUMEN INTRODUCCIÓN:El linfoma no Hodgkin (LNH) es una neoplasia que proviene de células linfocitarias con una amplia variabilidad de presentación clínica e histológica. El objetivo del presente estudio fue establecer el perfil de las características clínicas, demográficas e histopatológicas de los pacientes con diagnóstico de Linfoma No Hodgkin con el fin de describir la casuistica local, la sintomatología, histopatología y estadiaje en el momento del diagnóstico de la enfermedad. MÉTODO:Se realizó un estudio descriptivo retrospectivo en 223 pacientes con diagnóstico de Linfoma No Hodgkin que acudieron al Servicio de Oncología del hospital "José Carrasco Arteaga" durante el período de mayo 2009 a mayo de 2014. Se estudiaron las variables edad, sexo, localización del Linfoma, presencia de síntomas B, factores de riesgo, estadio en el momento del diagnóstico e histopatología; se utilizó la estadística descriptiva con frecuencias absolutas y relativas. RESULTADOS:La relación hombre-mujer fue de 1.45:1, el grupo etario más afectado fueron los adultos mayores (≥ 65 años), el síntoma B de mayor frecuencia fue la pérdida de peso (10.8%), la localización ganglionar fue la más frecuentemente comprometida (60.1%), el Linfoma Difuso de Células Grandes Inmunofenotipo B fue el más frecuente (59%) y los factores de riesgo más habituales fueron los antecedentes familiares de cáncer (43%), gastritis crónica (32%) y consumo de tabaco (25.9%).CONCLUSIONES: La frecuencia de LNH fue mayor en adultos mayores, es una enfermedad que en el medio se diagnostica en etapas tempranas (I-A y I-B); el síntoma B más frecuente fue la pérdida de peso. La mayor parte de los resultados obtenidos en el estudio fueron semejantes a los disponibles a nivel mundial, regional y local; se considera que los datos son extrapolables. *DESCRIPTORES DeCS BACKGROUND: Non-Hodgkin lymphoma (NHL) is a neoplasia that comes from lymphocyte cells with a wide variability of clinical and histological presentation. The aim of this study was to establish the profile of clinical, demographic and histopathological characteristics of patients diagnosed with non-Hodgkin lymphoma in order to describe the local casuistry, the symptoms, histopathology and staging at the time of diagnosis. METHODS: CONCLUSIONS:The frequency of NHL was higher in senior patients, the disease is diagnosed during early stages (I-A and I-B); the most frequent symptom was weight loss. These results were similar to those reported in worldwide, regional and local studies.

show abstract

“…As suggested by a recent meta-analysis, lower levels of carotenoids are also associated with an increased risk of breast cancer [31], with recent evidence suggesting that this association is stronger when carotenoids are assessed in blood [32]. Low serum levels of β – carotene have also been associated with an increased risk of colon and colorectal cancers [33] and non-Hodgkin lymphoma [34]. In contrast, higher levels of β-carotene appear to be associated with an increased risk of prostate cancer [35].…”

Section: Introductionmentioning

confidence: 99%

Race differences in the relation of vitamins A, C, E, and β-carotene to metabolic and inflammatory biomarkers

Suarez

Schramm-Sapyta

2014

Nutrition Research

View full text Add to dashboard Cite

Using archival data, we conducted a secondary analysis to examine race-differences in the relation of serum vitamins A, C, E and β-carotene to insulin resistance (IR), fasting insulin and glucose, high sensitivity C-reactive protein (hsCRP), and leukocyte count in 176 non-smoking, healthy, white and African American (AA) adults aged 18-65 years (48% women, 33% AA). We hypothesized that micronutrient concentrations would be associated with early risk markers of cardiometabolic diseases in a race-dependent manner. Fasting blood samples were analyzed for micronutrients, insulin, glucose, hsCRP, and leukocyte count. Insulin resistance was estimated using the homeostatic model assessment (HOMA). After adjusting for age, body mass index, gender, educational level, use of vitamin supplements, alcohol intake, leisure time physical activity, menopausal status, and total cholesterol, we observed that β-carotene was significantly associated with insulin resistance and fasting insulin in a race-dependent manner. Among AA, lower β-carotene levels were associated with higher estimates of insulin resistance and fasting insulin; whereas, these same associations were not significant for whites. Race also significantly moderated the relation of vitamin C to leukocyte count, with lower vitamin C being associated with higher leukocyte count only in AA but not whites. For all subjects, lower β-carotene was associated with higher hsCRP. In AA, but not whites, lower levels of β-carotene and vitamin C were significantly associated with early risk markers implicated in cardiometabolic conditions and cancer. Whether or not lower levels of micronutrients contribute uniquely to racial health disparities is a worthwhile aim for future research.

show abstract

Prediagnostic circulating carotenoid levels and the risk of non-Hodgkin lymphoma: the Multiethnic Cohort

Abstract: This analysis examined the association of non-Hodgkin lymphoma (NHL) with prediagnostic carotenoid levels, a marker for a diet rich in fruits and vegetables.

Cited by 18 publications

References 48 publications

Dietary and Lifestyle Factors and Risk of Non-Hodgkin's Lymphoma in Oman

Dietary and Lifestyle Factors and Risk of Non-Hodgkin's Lymphoma in Oman

Estudio Descriptivo: Características Clínicas, Demográficas E Histopatológicas De Pacientes Con Diagnóstico De Linfoma No Hodgkin.

Race differences in the relation of vitamins A, C, E, and β-carotene to metabolic and inflammatory biomarkers

Contact Info

Product

Resources

About