Predictable ovulation in mares treated with an implant of the GnRH analogue deslorelin

McKinnon, A. O.; Nobelius, Ann-Maree; Figueroa, S. Tarrida Del Marmol; Skidmore, Julian; Vasey, J. R.; Trigg, T. E.

doi:10.1111/j.2042-3306.1993.tb02972.x

Cited by 59 publications

(42 citation statements)

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“…The overall response rate of 87.8% and the rate of 82.2% of these mares ovulating within 48 hours confirmed similar values reported previously by Handler and Arbeiter (1996), Jöchle and Trigg (1994) and Meyers et al (1997). The mean interval between treatments and ovulations (ITO) of 44.9 h corresponded well with the range of intervals given with 40.5 and 49.1 h in prior study reports by Handler and Arbeiter (1996), Klug et al (1992), McKinnon et al (1993 and, Meinert et al (1993) and Meyers et al (1997). Of the factors evaluated, only the mares' reproductive status had a significant effect on the product effectiveness, while age, breed and parity had no effect.…”

Section: Discussionsupporting

confidence: 78%

“…Results obtained with Ovuplant in cyclic mares and their characteristics have been reviewed extensively (McKinnon et al 1993;Meinert et al 1993;Squires et al 1994;Jöchle and Trigg 1994;Mumford et al 1995;Meyers et al 1997). Deslorelin has also been used subsequent to the administration of progesterone by an intravaginal device (CIDR-B) for the treatment of anoestrous mares during the season (Arbeiter et al 1994) and for the induction of follicle growth and ovulation in transition phase mares (Arbeiter et al 1994;Handler et al 1999;Newcombe et al 2002).…”

Section: Introductionmentioning

confidence: 99%

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Einfluss von Stute, Zuchtmanagement und Tierarzt auf die Ovulationsinduktion und Fruchtbarkeit von mit dem GnRH-Analog Deslorelinazetat (Ovuplant™) behandelten Stuten.

Handler¹,

Arbeiter²,

Jöchle³

2004

PHK

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SummaryDuring the 1995 equine breeding season, 14 equine practitioners participated in a field trial to evaluate factors influencing the response to treatment with the short acting implant (Ovuplant TM ) of the GnRH analogue deslorelin, for induction and acceleration of ovulation. Evaluation of 148 individual reports included determination of ovulation (OR), ovulations occurring within 48 hours after treatment , the interval between treatment and ovulation (ITO) and the pregnancy rate (PR). Mare factors evaluated included breed, age, parity, reproductive status and mare management. Other factors examined were month of breeding, method of breeding and sperm characteristics, and the practitioner's contribution considering the share of equine clients in the entire patient base, years in practice, and reliability and precision in reporting. Neither breed, nor age nor parity had any influence on the effects of Ovuplant. Maiden mares had the longest ITO (51.9 ±19.5 h) and lactating mares the shortest (40.0 ±11.0 h), with a mean of 44.5 h for all mares. Mare management (breeding of single mares, of mares in stud farms or at breeding stations) had no influence on the treatment effect but mares bred at those breeding stations had low PR rates of 46.9% vs. 57.1 (single mares) and 68.5% (mares at stud farms), respectively. Month of breeding (January to October) had no significant effect on the response to treatment. Insemination with fresh semen resulted in the lowest PR (51.5%), with frozen/thawed semen and natural breeding the PR was 65.0% and 64.7%, respectively, and the PR overall was 57.5%. Differences between veterinarians were highly significant for ITO, approached significance for OV-48 and was again significant for OR with treatments of mares with follicles <30 mm and above. Number of mares treated per participating practitioner had no effects, but the share of horses in the entire client base significantly influences OV-48 for those with only 30% equine clients. Simultaneously, ITO was higher and PR lower. ITO was also influenced by years in practice, with highest values for those longest in practice. Response rates regarding OV-48 and ITO varied significantly between practitioners, and reliability regarding ITO as well. der Deckung/Besamung, der Samenart und der Anzahl der Besamungen pro Rosse charakterisiert. Der Beitrag der Tierärzte wurde anhand des Anteils an Pferdebesitzern am Gesamtklientel, der Dauer ihrer Berufsausübung sowie der Glaubwürdigkeit und der Genauigkeit ihrer Berichte beurteilt. Weder Rasse noch Alter und Anzahl der Trächtigkeiten hatten einen Einfluss auf die Wirksamkeit von Ovuplant. Maidenstuten wiesen ein signifikant längeres ITO (51,9 ±19,5 h) im Vergleich zu laktierenden Stuten (40,0 ±11,0 h) auf (P<0,05). Der Durchschnitt aller Stuten betrug 44,5 Stunden. Die Aufstallung der Tiere (Einzeltiere, Gestüte, Deckstationen) hatte ebenfalls keinen Einfluss auf den Erfolg der Ovulationsinduktion; aber die in Deckstationen besamten Stuten wiesen niedrigere PR (46,9 %) gegenüber in Einzelhaltung...

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Section: Discussionsupporting

confidence: 78%

Section: Introductionmentioning

confidence: 99%

Einfluss von Stute, Zuchtmanagement und Tierarzt auf die Ovulationsinduktion und Fruchtbarkeit von mit dem GnRH-Analog Deslorelinazetat (Ovuplant™) behandelten Stuten.

Handler¹,

Arbeiter²,

Jöchle³

2004

PHK

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“…DA uygulamalarını takiben ovulasyonun ortalama 44.5±48.0 saat içerisinde geçekleştiği belirtilmektedir (9,11). Folliküler büyüklük ≥30 mm çapında DA uygulandığı takdirde, ovulasyonun büyük oranda 48 saat içerisinde gerçekleşeceği pek çok araştırmacı tarafından belirtilmiştir (8, 15,18,19,25).…”

Section: Tartışma Ve Sonuçunclassified

“…Genelde 2.1 mg DA kısraklarda ovulasyonu hızlandırdığı, östrus periyodunu kısalttığı ve çiftleşme sayısını fertiliteyi bozmadan belirgin oranda azalttığı belirtilmiştir. DA uygulaması sırasında follikül büyüklüğünün ≥30 mm olması gerektiği ve uygulama sonrası 36 saat içinde ovulasyonun gerçekleştiği belirlenmiştir (3, 15,18,19,21). Ayrıca aşım sezonunda anöstrusta bulunan kısraklar ile (2) ilkbahar geçiş dönemindeki kısraklarda, follikül bü-yümesi ve ovulasyonun indüklenmesi amacıyla da DA kullanılmaktadır (2,9,22).…”

Section: Introductionunclassified

Reprodüktif açıdan sorunlu kısraklarda aşım sezonu başlangıcında uterus yıkamaları ve hormon kullanımının siklus aktivitesi ve fertilite parametreleri üzerindeki etkisi

Beceriklisoy¹,

Ay²,

Zonturlu³

et al. 2006

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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Özet: Bu çalışmanın amacı oksitosin destekli uterus yıkamalarını takiben yapılan hormon uygulamalarının önceki aşım sezonlarında birkaç kez çiftleştirilmelerine karşın gebe kalmayan kısraklarda follikül aktivitesi, ovulasyonun indüksiyonu ve gebelik sonuçları üzerindeki etkisini ortaya koymaktır. Çalışmada önceki aşım sezonlarında infertilite problemi görülen değişik ırklardan 12 kısrak kullanıldı. İntrauterin yıkama (8-10 litre %0.9 NaCl solusyonu en az üç gün süreyle akıntı temiz görülene kadar) hormon uygulamalarından önce, östrus başlangıcında tüm kısraklara uygulandı ve çiftleşmelerden sonra sorun saptananlarda yıkamalar yenilendi. Oksitosin (20 IU, i.v.) The effects of uterine lavage and hormonal treatments on follicular activity and some fertility parameters in the onset of breeding season in mares with reproductive failure Summary: The aim of this study was to investigate the effects of uterine lavage and concurrent oxytocin administrations followed by various hormonal treatments on follicular activity, induction of ovulation and pregnancy rates in mares with the history of infertility in previous breeding season. In this study, twelve different breed mares were used. Uterine lavages (8-10 litres of 0.9 % NaCl for at least 3 consecutive days until clean lavage fluid is observed) were done at the onset of oestrous before hormonal administrations and repeated after inseminations if necessary. Oxytocin was administered (20 IU i.v.) for 5 consecutive days. Mares were grouped as follows; Group I (n=4): Intravaginal CIDR-B (1.9 g progesterone) in diestrous for 10 days combined with i.m. PGF2α on day 7 and on the day of CIDR-B removal in combination with i.m. estradiolbenzoate (5 mg) and subcutaneous desloreline acetate (DA; a GnRH analogue; 2.1 mg, Ovuplant ® implant) as follicles reach the diameter of 30 mm. In group II (n=4); DA alone when follicles ≥30 mm are present. In group III (n=4); Control group, no hormonal treatments. Mean ovulation time following DA administrations was 41.16±8.15 h while ovulations occurred at 90.0±22.97 h after ultrasonographic detection of 35 mm diameter follicles in control group mares. Preovulatory follicles (≥35 mm) were detected at 84.0±30.7 h following CIDR-B removal and ovulation of these follicles occurred at 50.7±15.4 h of reaching preovulatory diameter. Percentages of ovulations were 70%, 100% and 40% in groups I, II and III, respectively. Six mares (75%) became pregnant in Group I and II. However, due to embryonic losses, four mares carried their pregnancies to term. Only one (25%) mare became pregnant in the control group. In conclusion, it was observed that uterine lavage and concurrent oxytocin administrations followed by various hormonal treatments were increased reproductive performance in stud farm mares with the history of infertility in previous breeding season.

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“…For example, administration of intermediateduration analogues, such as deslorelin, to estrous mares with 30-35-mm follicles is highly effective in inducing ovulation between 24 and 48 h later, providing a useful alternative to hCG [McKinnon et al, 1993]. The mare's ability to respond to continuous high-level GnRH-like stimulation and her resistance to "desensitization" are most likely attributable to the properties of the GnRH receptor on gonadotrophs.…”

Section: Initiation Of Cyclicity In the Nonbreeding Seasonmentioning

confidence: 99%

The Nonpregnant Mare: A Review of Some Current Research and of the Last 25 Years of Endocrinology

Irvine

1995

Biology of Reproduction

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Predictable ovulation in mares treated with an implant of the GnRH analogue deslorelin

Cited by 59 publications

References 3 publications

Einfluss von Stute, Zuchtmanagement und Tierarzt auf die Ovulationsinduktion und Fruchtbarkeit von mit dem GnRH-Analog Deslorelinazetat (Ovuplant™) behandelten Stuten.

Einfluss von Stute, Zuchtmanagement und Tierarzt auf die Ovulationsinduktion und Fruchtbarkeit von mit dem GnRH-Analog Deslorelinazetat (Ovuplant™) behandelten Stuten.

Reprodüktif açıdan sorunlu kısraklarda aşım sezonu başlangıcında uterus yıkamaları ve hormon kullanımının siklus aktivitesi ve fertilite parametreleri üzerindeki etkisi

The Nonpregnant Mare: A Review of Some Current Research and of the Last 25 Years of Endocrinology

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