Predicting blood lead concentrations from lead in environmental media.

Mahaffey, Kathryn R.

doi:10.1289/ehp.98106s61485

Cited by 6 publications

(2 citation statements)

References 45 publications

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“…For example, in an industrial context, taking into account bioavailability of metals is very important (Luthy et al, 2003). Furthermore, bioavailability can be highly relevant for decision making in health risk management (Casteel et al, 2001;Glorennec and Declercq, 2007;Mahaffey, 1998). The use of humans for bioavailability measurement is unlikely to be feasible, and animal use is also challenging in terms of cost, time and ethical issues (Saikai et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

French children's exposure to metals via ingestion of indoor dust, outdoor playground dust and soil: Contamination data

Glorennec

Lucas

Mandin

et al. 2012

Environment International

106

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Section: Introductionmentioning

confidence: 99%

French children's exposure to metals via ingestion of indoor dust, outdoor playground dust and soil: Contamination data

Glorennec

Lucas

Mandin

et al. 2012

Environment International

106

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“…However, as the WHO withdrew the PTWI for Pb [16] and also since Pb does not have a reference dose [17], health risk assessment of Pb from various environmental media and food requires translation of the Pb intake from these sources into BPb using biokinetic models. The predicted BPb are subsequently correlated with potential health effects that have been observed at various BPb ranges [18].…”

Section: Introductionmentioning

confidence: 99%

Issues and Challenges in the Application of the IEUBK Model in the Health Risk Assessment of Lead: A Case Study from Blantyre Malawi

Utembe

Gulumian

2021

IJERPH

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The risk assessment of lead (Pb) requires the use of biokinetic models to translate measured concentrations of Pb in food and environmental media into blood lead (BPb). The aim of this study was to assess the applicability of the Integrated Exposure Uptake Biokinetic (IEUBK) model in the health risk assessment of Pb among children in Blantyre. Children (152) aged 1–6 years were recruited into this cross-sectional study, and foods, house dust, playground soil, water, and venous blood (1 mL) were collected and analyzed for Pb. A seven-day food frequency questionnaire (FFQ) was used to collect food consumption data. The concentrations of Pb ranged from 0.01 to 3.3 mg/kg in food, 2.3 to 265 mg/kg and 1.5 to 482 mg/kg in house dust and playground soil, respectively, as well as 2.0 µg/dL to 50.4 µg/dL and 6.8 to 39.2 µg/dL for measured and predicted BPb, respectively. Various statistical tests indicated less than satisfactory agreement between measured and predicted BPb values. Despite the lack of reliable food consumption data and other limitations, both the predicted and measured BPb values indicate that children in Blantyre are exposed to high levels of Pb, largely through food and soil as a minor source.

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Tijuana Childhood Lead Risk Assessment Revisited: Validating a GIS Model with Environmental Data

Gonzalez

Pham

Ericson

et al. 2002

Environmental Management

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The objective of this research was to determine the spatial distributions of childhood lead poisoning and soil lead contamination in urban Tijuana. The Bocco-Sanchez model of point-source emissions was evaluated in terms of validity and reliability. We compared the model's predicted vulnerable populations with observed cases of childhood lead poisoning in Tijuana, identified fixed point sources in the field, and analyzed 76 soil samples from 14 sites. The soil lead results were compared to the blood lead analyses performed on Tijuana children whose blood lead levels were > or =10 microg/dL, who reported that they did not use lead-glazed ceramics for cooking or storing food (n = 63). Using GIS, predicted vs observed risk areas were assessed by examining spatial patterns, including the distribution of cases per designated risk area. Chi-square analysis of expected vs observed values did not differ significantly at the p = 0.02 level, showing that the model was strikingly accurate in predicting the distribution of subjects with elevated blood lead. Results reveal that while point sources are significant, other sources of lead exposure are also important. The relative public health risk from exposure to lead in an urban setting may be assessed by distinguishing among sources of exposure and associating concentrations to blood lead levels. The results represent an iterative approach in environmental health research by linking environmental and human biomarker lead concentrations and using these results to validate an environmental model of risk to lead exposure.

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Predicting blood lead concentrations from lead in environmental media.

Abstract: Policy statements providing health and environmental criteria for blood lead (PbB)

Cited by 6 publications

References 45 publications

French children's exposure to metals via ingestion of indoor dust, outdoor playground dust and soil: Contamination data

French children's exposure to metals via ingestion of indoor dust, outdoor playground dust and soil: Contamination data

Issues and Challenges in the Application of the IEUBK Model in the Health Risk Assessment of Lead: A Case Study from Blantyre Malawi

Tijuana Childhood Lead Risk Assessment Revisited: Validating a GIS Model with Environmental Data

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