Predicting Cardiac Structural And Functional Improvement On Left Ventricular Assist Device Support: The Externally Validated UCAR Score

Kyriakopoulos, Christos P.; Taleb, Iosif; Wever‐Pinzon, Omar; Selzman, Craig; Kfoury, Abdallah G.; Catino, Anna; Tseliou, Eleni; Stehlik, Josef; Alharethi, Rami; Fang, James C.; Koliopoulou, Antigone; Goodwin, Matthew; Kagawa, Hiroshi; Dranow, Elizabeth; Singh, Ramesh; Psotka, Mitchell A.; Birks, Emma J.; Slaughter, Mark S.; Koenig, Steven C.; Kyvernitakis, Andreas; Hoffman, Karlee; Guglin, Maya; Kotter, John; Vidic, Andrija; Raval, Nirav; Kanwar, Manreet; Shah, Palak; Drakos, Stavros G.

doi:10.1016/j.cardfail.2022.03.143

Cited by 1 publication

(3 citation statements)

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“…There was a similar explanation rate reported in the Momentum 3 trial 5‐year outcomes study of 0.8% at 5 years 3 . In centers that actively screen for myocardial recovery, defined as LVEF > 40% and LV end‐diastolic diameter (LVEDD) < 6 cm, successful explantation has been reported in as many as ~18%–20% of patients 40 …”

Section: Lvad Patient Recovery Characteristicssupporting

confidence: 69%

“…3 In centers that actively screen for myocardial recovery, defined as LVEF > 40% and LV end-diastolic diameter (LVEDD) < 6 cm, successful explantation has been reported in as many as ~18%-20% of patients. 40 Independent predictors of recovery include: age <50 years, etiology of nonischemic cardiomyopathy, and time from cardiac diagnosis <2 years, absence of implantable cardiac defibrillators, creatinine ≤1.2 mg/dL, and LVEDD < 6.5 cm (p < .0001). In a cohort of 190 patients with LVADs, a weighted score was developed (I-CARS score) to effectively stratify patients based on their probability of recovery.…”

Section: Lvad Patient Recovery Characteristicsmentioning

confidence: 99%

“… 3 In centers that actively screen for myocardial recovery, defined as LVEF > 40% and LV end‐diastolic diameter (LVEDD) < 6 cm, successful explantation has been reported in as many as ~18%–20% of patients. 40 …”

Section: Lvad Patient Recovery Characteristicsmentioning

confidence: 99%

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LVAD therapy as a catalyst to heart failure remission and myocardial recovery

Hamad

Byku

Larson

et al. 2023

Clinical Cardiology

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The management of chronic heart failure over the past decade has witnessed tremendous strides in medical optimization and device therapy including the use of left ventricular assist devices (LVAD). What we once thought of as irreversible damage to the myocardium is now demonstrating signs of reverse remodeling and recovery. Myocardial recovery on the structural, molecular, and hemodynamic level is necessary for sufficient recovery to withstand explant and achieve sustained recovery post‐LVAD. Guideline‐directed medical therapy and unloading have been shown to aid in recovery with the potential to successfully explant the LVAD. This review will summarize medical optimization, assessment for recovery, explant methodologies and outcomes post‐recovery with explant of durable LVAD.

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Section: Lvad Patient Recovery Characteristicssupporting

confidence: 69%

Section: Lvad Patient Recovery Characteristicsmentioning

confidence: 99%