Predicting Cardiovascular Risk in Type 2 Diabetes: the Heterogeneity Challenges

Gore, M. Odette; McGuire, Darren K.; Lingvay, Ildiko; Rosenstock, Julio

doi:10.1007/s11886-015-0607-7

Cited by 31 publications

(20 citation statements)

References 86 publications

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“…Our findings are also consistent with previous epidemiological studies, reported that patients have DR have a higher incidence to develop cardiovascular disease [3,4] .…”

Section: Discussionsupporting

confidence: 94%

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Correlation between Diabetic Retinopathy and the Severity of Coronary Artery Disease Determined by Coronary Angiography in Patients with Type II Diabetes Mellitus

Attia

Elraghy

Elgazar

et al. 2019

International Journal of Medical Arts

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Background: Diabetes mellitus [DM] is one of the most widespread chronic diseases. It is commonly known by its serious vascular complications including micro-vascular [as retinopathy] and macro-vascular [as ischemic heart diseases] complications. So, a correlation between those complications may be found. Aim of the work: To investigate the correlation between diabetic retinopathy and increased risk of coronary artery diseases. Patients and methods: This study enrolled fifty patients with type 2 diabetes mellitus [DM] who were referred for coronary angiography. Full History, clinical examination, biochemical tests, electrocardiography [ECG], Echocardiography, coronary angiography and fundus examination were carried out. Diabetic retinopathy was detected and classified; patients were classified into two groups: a group [A] with diabetic retinopathy [DR] and a group [B] without diabetic retinopathy. Coronary diseases were assisted by coronary angiography using two different scores. Results: Population characters, including age, risk factors, duration of DM, lipid profile, angiography scores, were comparable between the two study groups. Patients in group [A] had significantly higher number of diseased vessels and higher Gensini score than those of Group [B]. The correlation was significant between the presence of the DR and both the number of diseased vessels [r = 0.532 P < 0.001] and Gensini score [r = 0.881, P < 0.001]. Conclusion: The diabetic retinopathy is a serious risk factor for increasing the severity of coronary artery diseases and can consider as a predictor of CHD in patients with DR.

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“…Our findings are also consistent with previous epidemiological studies, reported that patients have DR have a higher incidence to develop cardiovascular disease [3,4] .…”

Section: Discussionsupporting

confidence: 94%

“…Although diabetes was once deemed as a risk for CAD risk, heterogeneity of such risk was also increasingly recognized, making the new guidelines looking for a new assessment tool to specifically assess the risk for diabetic patients [3,4] .…”

Section: Introductionmentioning

confidence: 99%

Correlation between Diabetic Retinopathy and the Severity of Coronary Artery Disease Determined by Coronary Angiography in Patients with Type II Diabetes Mellitus

Attia

Elraghy

Elgazar

et al. 2019

International Journal of Medical Arts

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“…Psychosocial stress factors can be divided into negative emotional disorders (e.g., depression and anxiety), personal traits (e.g., anger or hostility), and external stressors (exposure to stressful conditions). The evidence relating sociodemographic, behavioral, and clinical risk factors with CVD risk in people with diabetes was reviewed in this journal in 2015 [22]. This article did not cover the role of psychosocial factors in diabetes and their association with CVD risk.…”

Section: Cvd and Diabetes: A Link Beyond Traditional Risk Factorsmentioning

confidence: 99%

Psychosocial Factors in Diabetes and Cardiovascular Risk

2016

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Type 2 diabetes is a chronic disease that is increasing in prevalence globally. Cardiovascular disease is a major cause of mortality and morbidity in diabetes, and lifestyle and clinical risk factors do not fully account for the link between the conditions. This article provides an overview of the evidence concerning the role of psychosocial stress factors in diabetes risk, as well as in cardiovascular complications in people with existing diabetes. Several types of psychosocial factors are discussed including depression, other types of emotional distress, exposure to stressful conditions, and personality traits. The potential behavioral and biological pathways linking psychosocial factors to diabetes are presented and implications for patient care are highlighted.

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“…Type 2 diabetes is associated with a 2‐ to 3‐fold increased risk of coronary artery disease and CV mortality . The risk of CVD in diabetes depends largely on the concomitant presence of other traditional CV risk factors including LDL cholesterol levels, high blood pressure and smoking; however, these risk factors do not fully explain the heterogeneity of CV risk in diabetes . The role of proprotein‐convertase‐subtilisin/kexin type 9 (PCSK9) in familial hypercholesterolaemia and its CV complications was identified by Abifadel et al PCSK9 is a serine protease that regulates cholesterol metabolism via LDL receptor (LDLR) degradation.…”

Section: Introductionmentioning

confidence: 99%