Predicting disease-related and patient-reported outcomes in older patients with breast cancer - a systematic review

Plas-Krijgsman, Willeke G van der; Boer, Anna Z. de; Jong, Pauline de; Bastiaannet, E.; Bos, Frederiek van den; Mooijaart, Simon P.; Liefers, G.J.; Portielje, Johanneke E.A.; Glas, Nienke A. de

doi:10.1016/j.jgo.2021.01.008

Cited by 13 publications

(7 citation statements)

References 34 publications

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“…Although severe and persistent side effects were assessed in the majority of studies, quality of life was underappreciated and included only in half of the studies. These findings are in line with previous research [ 52 , 53 , 54 , 55 , 56 , 57 , 58 ]. In our subgroup analysis of older patients, quality of life was assessed in the majority (75%), and together with overall survival, most frequently prioritized (83%).…”

Section: Discussionsupporting

confidence: 93%

Patient Preferences for Treatment Outcomes in Oncology with a Focus on the Older Patient—A Systematic Review

Seghers

Wiersma

Festen

et al. 2022

Cancers

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For physicians, it is important to know which treatment outcomes are prioritized overall by older patients with cancer, since this will help them to tailor the amount of information and treatment recommendations. Older patients might prioritize other outcomes than younger patients. Our objective is to summarize which outcomes matter most to older patients with cancer. A systematic review was conducted, in which we searched Embase and Medline on 22 December 2020. Studies were eligible if they reported some form of prioritization of outcome categories relative to each other in patients with all types of cancer and if they included at least three outcome categories. Subsequently, for each study, the highest or second-highest outcome category was identified and presented in relation to the number of studies that included that outcome category. An adapted Newcastle–Ottawa Scale was used to assess the risk of bias. In total, 4374 patients were asked for their priorities in 28 studies that were included. Only six of these studies had a population with a median age above 70. Of all the studies, 79% identified quality of life as the highest or second-highest priority, followed by overall survival (67%), progression- and disease-free survival (56%), absence of severe or persistent treatment side effects (54%), and treatment response (50%). Absence of transient short-term side effects was prioritized in 16%. The studies were heterogeneous considering age, cancer type, and treatment settings. Overall, quality of life, overall survival, progression- and disease-free survival, and severe and persistent side effects of treatment are the outcomes that receive the highest priority on a group level when patients with cancer need to make trade-offs in oncologic treatment decisions.

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Section: Discussionsupporting

confidence: 93%

Patient Preferences for Treatment Outcomes in Oncology with a Focus on the Older Patient—A Systematic Review

Seghers

Wiersma

Festen

et al. 2022

Cancers

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“…This type of surgery is designed for vulnerable patients who may or may not have comorbidities and disabilities. Since frailty is a dynamic symptom of disease or injury increasing the vulnerability of the patient to stressors that often causes difficulties in hospitalization [ 1 , 2 , 7 , 9 , 14 , 15 , 30 ]. The eligibility criteria for the “Cut&Sew” approach are: i) patients with advanced age and/or comorbidities; ii) frail patients who psychologically do not accept other kind of surgery; iii) patients who do not require sentinel lymph node biopsy (SLNB); and iv) patients who need surgical biopsy for lesions classified as B3 or a small one with a dubious radiological image.…”

Section: Methodsmentioning

confidence: 99%

“…Such a well-documented relationship between older age and a delay in BC diagnosis is associated with larger tumors and more advanced stage at presentation [ [7] , [8] , [9] ], a situation usually referred to as neoadjuvant hormonal medical treatment for 4–6 months after which patients either continue with medical therapy or opt for surgery facing some risks [ 10 ]. The percentage of patients not receiving any surgery, axillary surgery, increases with age in many countries [ 11 ], and about one-third of treatment omissions were due to patient preference [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Healthcare delivery to elderly and unfit patients with breast disease and comorbidities under an outpatient regime: A report of a personal surgical technique named “Cut&Sew”

Rassu

2023

Surgery Open Science

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“…A systematic review by van der Plas-Krijgsman et al (2021) found that most breast cancer research focuses on disease-related issues, survival, and toxicity outcomes. Likewise, most research on the health needs of family caregivers of older women with breast cancer has focused on psychological health (Yu et al, 2021), as evidenced by the preceding section of this manuscript.…”

Section: Rationale and Objectivesmentioning

confidence: 99%

A Scoping Review of the Physical Health Needs of Family Caregivers of Older Women With Breast Cancer

Felix¹,

Kitcharoen²,

Le³

et al. 2022

JPSS

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This scoping review conducted mapping of relevant literature on the physical health needs of family caregivers of older women with breast cancer, gaps analysis, and suggests directions for future academic research. The PRISMA-ScR checklist by Tricco et al. (2018) guided the scoping review. Ten international databases were searched for academic articles published in English between January 2002 and January 2022. The 12,795 discovered articles were reduced to two sources of evidence. Extracted data were mapped out using a charting table. The analysis revealed a dearth of research on the subject of physical health of family caregivers of older women with breast cancer, a lack of detailed description of the physical health needs of family caregivers of older women with breast cancer, a lack of cultural, geographic, and ethnic diversity, a lack of studies on the physical needs/strains experienced by family caregivers aside from physical activity needs, underutilized research methodologies, gender differences that influence physical health needs of family caregivers, development of research tools, and lack of intervention/educational programs on physical health for family caregivers. Future research directions were suggested, and limitations were presented.

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Predicting disease-related and patient-reported outcomes in older patients with breast cancer - a systematic review

Cited by 13 publications

References 34 publications

Patient Preferences for Treatment Outcomes in Oncology with a Focus on the Older Patient—A Systematic Review

Patient Preferences for Treatment Outcomes in Oncology with a Focus on the Older Patient—A Systematic Review

Healthcare delivery to elderly and unfit patients with breast disease and comorbidities under an outpatient regime: A report of a personal surgical technique named “Cut&Sew”

A Scoping Review of the Physical Health Needs of Family Caregivers of Older Women With Breast Cancer

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