Predicting EEG responses using MEG sources in superior temporal gyrus reveals source asynchrony in patients with schizophrenia

Generators of the intracranial P50 response in auditory sensory gating

“…First, since major maximums of gatingrelated changes (GDW results) were localized in the frontal lobe areas it is possible to suggest that a cortical network localized at the frontal lobe plays an important role in providing mechanisms of gating. Second, since in the present study the amount of gating-related activity at the frontal lobe was relatively larger than at the temporal and number of MEG studies Huang et al, 2003) showed significant gating-related changes in the temporal lobe it is reasonable to suggest that combination of neuronal activity in these two brain regions result in the phenomenon of gating observable from the scalp recordings. Taking into account differences between the present results and MEG studies, it is possible that there is a difference in brain mechanisms of gating inherent in the frontal and temporal lobes.…”

“…While magnetic fields originating from neurons in Heschl's gyrus are usually oriented tangentially with respect to the head surface, and therefore may be readily detected, frontal lobe activity might have predominantly radial orientation, and thus may not be well evaluated with MEG sensors. In contrast to MEG studies Hanlon et al, 2005;Huang et al, 2003;Onitsuka et al, 2000;Reite et al, 1988;Thoma et al, 2003), the present study reflected electric signals sampled from relatively limited cortical areas using high density electrode arrays. These considerations may explain differences between our LORETA results and previous MEG-derived models of P50/M50 generators.…”

The effects of increased serotonergic activity on human sensory gating and its neural generators

“…Indeed, studies where MEG and EEG methodology were used simultaneously point toward additional generators of the P50-evoked potential: Huotilainen et al (1998) found that sources located in the auditory cortex did not fully explain EEG data but only MEG data, indicating additional generators of the P50-evoked potential, while Onitsuka et al (2000) found that the P50 amplitude did not decrease in a manner similar to the M50 when the ISI was manipulated, indicating that different generators were responsible for generating P50 and M50. Furthermore, in a study by Huang et al (2003), it was concluded that the 40-Hz activity in EEG recordings, after subtraction of activity from sources in the supra temporal gyrus that were identified by MEG, probably was due to activity from additional neural generators. A further complication in the comparison between source localization in MEG and EEG is that it is still unclear to which degree the M50 and the P50 are analogue .…”

Evoked and induced oscillatory activity contributes to abnormal auditory sensory gating in schizophrenia

“…This response attenuation is thought to reflect the ability of the brain to inhibit the processing of repeated information, a mechanism that protects the processing of irrelevant information (Adler et al, 1982;Boutros et al, 2009;Clementz et al, 1997;Edgar et al, 2008;Freedman et al, 1987;Huang et al, 2003). In the auditory modality, sensory gating has usually been studied in a paired-click paradigm: two brief click stimuli are presented with 500 ms stimulus onset asynchrony.…”