“…So, it is necessary to study the probable influences of random perturbation in the process of cancer evolution. In fact, in recent years, many scholars have studied the influence of noise on some nonlinear systems [39,40,13,41,42,43,35]. Moreover, many works study the effect of noise on cancer dynamics analytically and numerically, and many stochastic characters have been discovered, such as stochastic bifurcation [4,1], first extinction time [8,25], noise induced extinction [17], stochastic resonance [9,18,44], resonant activation [36,28,26], noise enhanced stability [10,29], and transient dynamics of biological systems [5,11,33,3,6,34].…”