Predicting Hematoma Expansion After Primary Intracerebral Hemorrhage

Clinical Prediction Algorithm (BRAIN) to Determine Risk of Hematoma Growth in Acute Intracerebral Hemorrhage

“…However, the C-statistic of a recently published ICH growth prediction model that included CTA spot sign was 0.72 for the development cohort and 0.77 for the validation cohort, 11 which is comparable with the BRAIN score. Finally, as over 90% of subjects were Chinese in the validation cohort, the BRAIN score may need to be further validated in other ethnic populations.…”

“…10 Many other individual associations have been described, but the small sample size of many of these studies has often limited the ability to perform multivariable analyses adjusted for known confounders and associations with ICH growth. One recent study with sufficient power was able to develop and validate a prediction model (which included warfarin anticoagulation use, presence of the CTA spot sign, shorter time to computed tomography [CT], and baseline ICH volume), 11 but the retrospective analysis and use of CTA and repeat brain imaging only whenever concern Background and Purpose-We developed and validated a simple algorithm to predict the risk of hematoma growth in acute spontaneous intracerebral hemorrhage (ICH) to better inform clinicians and researchers in their efforts to improve outcomes for patients. Methods-We analyzed data from the computed tomography substudies of the pilot and main phases of the Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trials (INTERACT1 and 2, respectively).…”

Prognostic Significance of Serum Calcium Level in a Sample of Egyptian Patients With Intracerebral Hemorrhage.

“…It has no proved specific therapy to improve the outcomes according to the results of randomized clinical trials 21 .…”

Association Between Serum Calcium Level and Extent of Bleeding in Patients with Intracerebral Hemorrhage

“…This imaging marker likely reflects active bleeding, is more commonly detected in patients with impaired hemostatic function, 23,24 and is strongly associated with hematoma expansion. 19,20 From a clinical and therapeutic perspective, hematoma volume on admission and ICH expansion are potentially modifiable determinants of ICH outcome 2,25 and, therefore, represent appealing targets for several ICH therapeutic strategies. 26,27 Given the influence of serum calcium level on ICH volume and expansion, there may be a therapeutic opportunity.…”