The objective of this study is to examine the prognosis of acute cognitive disorders post-stroke, and to evaluate which clinical factors predict domain-specific cognitive recovery. We followed the course of cognitive functioning in 111 stroke patients and 77 healthy controls by administering two neuropsychological examinations with a 6 to 10 month interval (mean interval, 7.5 6 1.3 months). The baseline examination was administered within three weeks post-stroke (mean interval, 7.9 6 4.2 days). To examine determinants of domain-specific cognitive recovery, we recorded vascular risk factors, clinical variables, and lesion characteristics. Recovery in visual perception0construction (83%) and visual memory (78%) was the most common. An acute cognitive disorder predicted a long-term disorder in the same domain (all p , .05), except for visual perception0construction. Factors associated with poor cognitive recovery were age (all p , .01), preexistent verbal ability (all p , .005), lesion locations involving the temporal (all p , .05), frontal ( p , .05) and occipital lobe (all p , .05), lesion volume ( p Յ .001), and diabetes mellitus ( p , .01). An early neuropsychological examination provides valuable information on long-term cognitive performance. The prognosis of higher-level visual disorders is the most favorable. Cognitive recovery is associated with age, preexistent ability, lesion volume, lesion location, and diabetes mellitus. (JINS, 2005, 11, 795-806.)