Predicting Malignancy of Biliary Stricture with a Nomogram in Patients with a Non-Malignant Endoscopic Tissue Diagnosis: A Retrospective Study

Zhang, Yizhen; Jiang, Qingwei; Wang, Qiang; Feng, Yunlu; Wu, Datong; Guo, Tao; Zhang, Shengyu; Chen, Xi; Yang, Yingyun; Shi, Wen; Wu, Xi; Yang, Aiming

doi:10.2147/cmar.s333333

Cited by 2 publications

(1 citation statement)

References 50 publications

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“…Hasil ini juga sejalan dengan penelitian Zhang Y dkk. 28 yang menujukkan bahwa median kadar bilirubin serum pasien dengan neoplasma (11,2 mg/dL) lebih tinggi daripada non-neoplasma (4,3 mg/dL).…”

Section: Kadar Bilirubin Serum Dari Kelompok Neoplasma Dan Non-neoplasmaunclassified

Perbedaan Kadar Bilirubin Serum antara Kelompok Patologi Neoplasma dan Non-neoplasma pada Ikterus Obstruktif

Sakina

Suchitra

Yenita

2022

JIKESI

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Latar Belakang: Ikterus obstruktif merupakan kondisi dari adanya kelainan yang menyebabkan obstruksi pada sistem bilier. Salah satu pemeriksaan awal dan rutin yang dilakukan untuk membedakan kelainan yang menyebabkan ikterus adalah pemeriksaan kadar bilirubin serum. Objektif: Untuk mengetahui apakah terdapat perbedaan kadar bilirubin serum antara kelompok patologi neoplasma dan non-neoplasma pada pasien dengan ikterus obstruktif. Metode: Jenis penelitian ini adalah analitik observasional dengan desain cross-sectional menggunakan data rekam medis pasien ikterus obstruktif ekstrahepatik yang ditatalaksana di RSUP Dr. M. Djamil Padang pada Januari 2019 – Desember 2021 dengan jumlah sampel pada penelitian ini adalah 21 sampel untuk masing-masing kelompok. Analisis data dilakukan dengan uji Mann-whitney. Hasil: Perempuan (54,8%) lebih banyak dan kelompok usia terbanyak adalah 56 – 65 tahun (38,1%). Kelainan terbanyak adalah tumor di pankreas pada kelompok neoplasma (57,1%) dan koledokolitiasis (85,7%) pada kelompok non-neoplasma. Rerata kadar bilirubin kelompok neoplasma adalah 14,6 ± 8,99 mg/dL dan kelompok non-neoplasma adalah 8,14 ± 8,82 mg/dL dengan nilai p=0,015. Kesimpulan: terdapat perbedaan yang bermakna antara kadar bilirubin serum kelompok neoplasma dan non-neoplasma pada pasien dengan ikterus obstruktif di RSUP Dr. M. Djamil Padang. Kata kunci: bilirubin, neoplasma, non-neoplasma, ikterus obstruktif

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Section: Kadar Bilirubin Serum Dari Kelompok Neoplasma Dan Non-neoplasmaunclassified

Perbedaan Kadar Bilirubin Serum antara Kelompok Patologi Neoplasma dan Non-neoplasma pada Ikterus Obstruktif

Sakina

Suchitra

Yenita

2022

JIKESI

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A machine learning-based predictive model for biliary stricture attributable to malignant tumors: a dual-center retrospective study

Yang,

Nie,

et al. 2024

Front. Oncol.

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BackgroundBiliary stricture caused by malignant tumors is known as Malignant Biliary Stricture (MBS). MBS is challenging to differentiate clinically, and accurate diagnosis is crucial for patient prognosis and treatment. This study aims to identify the risk factors for malignancy in all patients diagnosed with biliary stricture by Endoscopic Retrograde Cholangiopancreatography (ERCP), and to develop an effective clinical predictive model to enhance diagnostic outcomes.MethodologyThrough a retrospective study, data from 398 patients diagnosed with biliary stricture using ERCP between January 2019 and January 2023 at two institutions: the First People’s Hospital affiliated with Jiangsu University and the Second People’s Hospital affiliated with Soochow University. The study began with a preliminary screening of risk factors using univariate regression. Lasso regression was then applied for feature selection. The dataset was divided into a training set and a validation set in an 8:2 ratio. We analyzed the selected features using seven machine learning algorithms. The best model was selected based on the Area Under the Receiver Operating Characteristic (ROC) Curve (AUROC) and other evaluation indicators. We further evaluated the model’s accuracy using calibration curves and confusion matrices. Additionally, we used the SHAP method for interpretability and visualization of the model’s predictions.ResultsRF model is the best model, achieved an AUROC of 0.988. Shap result indicate that age, stricture location, stricture length, carbohydrate antigen 199 (CA199), total bilirubin (TBil), alkaline phosphatase (ALP), (Direct Bilirubin) DBil/TBil, and CA199/C-Reactive Protein (CRP) were risk factors for MBS, and the CRP is a protective factor.ConclusionThe model’s effectiveness and stability were confirmed, accurately identifying high-risk patients to guide clinical decisions and improve patient prognosis.

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Predicting Malignancy of Biliary Stricture with a Nomogram in Patients with a Non-Malignant Endoscopic Tissue Diagnosis: A Retrospective Study

Cited by 2 publications

References 50 publications

Perbedaan Kadar Bilirubin Serum antara Kelompok Patologi Neoplasma dan Non-neoplasma pada Ikterus Obstruktif

Perbedaan Kadar Bilirubin Serum antara Kelompok Patologi Neoplasma dan Non-neoplasma pada Ikterus Obstruktif

A machine learning-based predictive model for biliary stricture attributable to malignant tumors: a dual-center retrospective study

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