Predicting persistence of hallucinations from childhood to adolescence

Steenkamp, Lisa R.; Tiemeier, Henning; Blanken, Laura M. E.; Hillegers, Manon H. J.; Kushner, Steven A.; Bolhuis, Koen

doi:10.1192/bjp.2021.115

Cited by 16 publications

(11 citation statements)

References 36 publications

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“… 11 – 13 Most studies examine cross-sectional estimates of PLEs, although research has examined persistence of PLEs. 12 , 14 – 23 Previous research indicates that persistent PLEs are associated with subsequent onset of psychotic disorders. 11 , 19 The level of distress elicited by PLEs may also distinguish clinically-relevant PLEs, 13 , 24 – 27 including predicting transition from clinical high-risk to psychotic disorders.…”

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confidence: 99%

Persistent and distressing psychotic-like experiences using adolescent brain cognitive development℠ study data

et al. 2021

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Childhood psychotic-like experiences (PLEs) are associated with a range of impairments; a subset of children experiencing PLEs will develop psychiatric disorders, including psychotic disorders. A potential distinguishing factor between benign PLEs versus PLEs that are clinically relevant is whether PLEs are distressing and/or persistent. The current study used three waves of Adolescent Brain Cognitive Development ℠ (ABCD) study PLEs assessments to examine the extent to which persistent and/or distressing PLEs were associated with relevant baseline risk factors (e.g., cognition) and functioning/mental health service utilization domains. Four groups varying in PLE persistence and distress endorsement were created based on all available data in ABCD Release 3.0, with group membership not contingent on complete data: persistent distressing PLEs (n=272), transient distressing PLEs (n=298), persistent non-distressing PLEs (n=221), and transient non-distressing PLEs (n=536) groups. Using hierarchical linear models, results indicated youth with distressing PLEs, whether transient or persistent, showed delayed developmental milestones ( β =0.074, 95%CI:0.013,0.134) and altered structural MRI metrics ( β =−0.0525, 95%CI:−0.100,−0.005). Importantly, distress interacted with PLEs persistence for the domains of functioning/mental health service utilization ( β =0.079, 95%CI:0.016,0.141), other reported psychopathology ( β =0.101, 95%CI:0.030,0.170), cognition ( β =−0.052, 95%CI:0.−0.099,−0.002), and environmental adversity ( β =0.045, 95%CI:0.003,0.0.86; although no family history effects), with the interaction characterized by greatest impairment in the persistent distressing PLEs group. These results have implications for disentangling the importance of distress and persistence for PLEs with regards to impairments, including functional, pathophysiological, and environmental outcomes. These novel longitudinal data underscore that it is often only in the context of distress that persistent PLEs were related to impairments.

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confidence: 99%

Persistent and distressing psychotic-like experiences using adolescent brain cognitive development℠ study data

et al. 2021

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“…Several recent studies reported on the persistence of PEs among children and adolescents (e.g. Karcher et al, 2021; Steenkamp et al, 2021). However, since risk factors and expression of PE differs between this young age group and adults [e.g.…”

Section: Introductionmentioning

confidence: 99%

Prevalence, incidence, and persistence of psychotic experiences in the general population: results of a 9-year follow-up study

et al. 2022

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Background Psychotic experiences (PEs) frequently occur and are associated with a range of negative health outcomes. Prospective studies on PEs are scarce, and to date no study investigated PE prevalence, incidence, persistence, their risk indicators, and psychiatric comorbidity, in one dataset. Furthermore, most studies are based on self-report, and it is unclear how this compares to clinical interviews. Methods Data are used from the Netherlands Mental Health Survey and Incidence Study-2 (NEMESIS-2), a psychiatric cohort study among a representative sample of adults (baseline characteristics: N = 6646; 49.6% female; 18–64 years). Results are presented for self-reported and clinically validated PEs. Associations are assessed for mental disorders, socio-demographic, vulnerability, physical health, and substance use factors. Results Based on self-report, at baseline 16.5% of respondents had at least one PE in their lifetime, of those, 30.1% also reported a PE at 3-year follow-up. 4.8% had a first PE at 3-year follow up. The 3-year prevalence of PE was associated with almost all studied risk indicators. Generally, the strongest associations were found for mental health disorders. Prevalence and incidence rates were two to three times higher in self-report than in clinical interview but results on associated factors were similar. Conclusions Validated prevalence and incidence estimates of PE are substantially lower than self-reported figures but results on associated factors were similar. Therefore, future studies on associations of PEs can rely on relatively inexpensive self-reports of PEs. The associations between PE and mental disorders underline the importance of assessment of PE in general practice.

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“…Despite a number of known risk factors, in a recent scoping review, Kalman et al ( 2019 ) failed to find any consistent evidence of risk factors for recurring PE. Modelling techniques to develop predictive models of recurring v. transient PE found a similar limitation using current known risk factors (AUC = 0.66, 7.4% of variance, Sensitivity = 68.8%; Specificity = 54.4%) (Steenkamp et al, 2021 ), although the model did differentiate recurring PE from control.…”

Section: Objectivesmentioning

confidence: 97%

Psychotic experiences in the general population, a review; definition, risk factors, outcomes and interventions

et al. 2022

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Psychotic experiences (PE) are common in the general population, in particular in childhood, adolescence and young adulthood. PE have been shown to be associated with an increased risk for later psychotic disorders, mental disorders, and poorer functioning. Recent findings have highlighted the relevance of PE to many fields of healthcare, including treatment response in clinical services for anxiety & depression treatment, healthcare costs and service use. Despite PE relevance to many areas of mental health, and healthcare research, there remains a gap of information between PE researchers and experts in other fields. With this review, we aim to bridge this gap by providing a broad overview of the current state of PE research, and future directions. This narrative review aims to provide an broad overview of the literature on psychotic experiences, under the following headings: (1) Definition and Measurement of PE; (2) Risk Factors for PE; (3) PE and Health; (4) PE and Psychosocial Functioning; (5) Interventions for PE, (6) Future Directions.

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Predicting persistence of hallucinations from childhood to adolescence

Cited by 16 publications

References 36 publications

Persistent and distressing psychotic-like experiences using adolescent brain cognitive development℠ study data

Persistent and distressing psychotic-like experiences using adolescent brain cognitive development℠ study data

Prevalence, incidence, and persistence of psychotic experiences in the general population: results of a 9-year follow-up study

Psychotic experiences in the general population, a review; definition, risk factors, outcomes and interventions

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