Predicting persistent organ failure on admission in patients with acute pancreatitis: development and validation of a mobile nomogram

Shi, Na; Zhang, Xiaoxin; Zhu, Yin; Deng, Lihui; Li, Lan; Zhu, Ping; Xia, Liang; Jin, Tao; Ward, Thomas; Sztamary, Peter; Cai, Wenhao; Yao, Linbo; Yang, Xunzhe; Lin, Ziqi; Jiang, Kun; Guo, Jia; Yang, Xiaonan; Singh, Vikesh K.; Lü, Nonghua; Windsor, John A.; He, Wenhua; Huang, Wei; Xia, Qing

doi:10.1016/j.hpb.2022.05.1347

Cited by 5 publications

(2 citation statements)

References 55 publications

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“…Jiang 26 and Xu’s 27 articles are also based on the MIMIC-III database, the former includes too few patients, while Xu uses TBIL as the grouping basis and paid more attention to changes in liver function. The patients selected by Shi 28 are mainly mild AP, which is significantly different from our model’s prediction goals. Moreover, the above-mentioned models have not taken into account the effect of ferroptosis and have not comprehensively analyzed indicators such as serum iron, lactate, and ALP.…”

Section: Discussionmentioning

confidence: 65%

Serum iron fluctuations link ferroptosis process with mortality and prognosis of acute pancreatitis

Deng,

Jiang,

et al. 2023

iScience

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Section: Discussionmentioning

confidence: 65%

Serum iron fluctuations link ferroptosis process with mortality and prognosis of acute pancreatitis

Deng,

Jiang,

et al. 2023

iScience

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“…It was well known that malnutrition is a significant risk factor for morbidity and mortality after gastrointestinal surgery. The nutritional risk index (NRI) and the NLR are two well-tested tools that are used for diagnosis and prognosis outcomes in surgery [ 22 – 26 ]. For many years, the nutritional status of the patient before surgery was considered one of the key factors influencing the occurrence of various complications after surgery, and there are several studies on the possibility of using the NRI as a screening tool for malnutrition to predict postoperative complications and the impact on patient survival [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

Physiological stress level and screening for malnutrition as preoperative predictors of postoperative complications in pancreatic surgery: a retrospective study

Кryvoruchko¹,

Staikov²,

Boyko³

et al. 2023

BMC Surg

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Background Assessment of ‘physiological stress levels’ and ‘nutritional status’ before surgery is important for predicting complications and indirect interventions on the pancreas. The aim of this study was to determine neutrophil–lymphocyte ratio (NLR) and nutritional risk index (NRI) indicators before surgery to predict 90-day complications and mortality in a cohort of patients with complicated chronic pancreatitis and cancer of the head of the pancreas. Methods We evaluated preoperative levels of NLR and NRI among 225 subjects treated at different centres located in three countries. Short-term outcomes included length of hospital stay, postoperative complications, and mortality at 90 days and were appreciated based on NLR and NRI. The level of physiological stress was divided according by the formulas: neutrophil–lymphocyte ratio (NLR) = (neutrophil count, %)/(lymphocyte count, %). The nutritional state of the patients was divided according to the INR: NRI = (1.519 × serum albumin, g/L) + (41.7 × present weight, kg / usual weight, kg)]. Results All patients were operated. An analysis of the operations performed in three institutions demonstrated mortality in chronic pancreatitis and pancreatic pseudocysts in 1.4%, in chronic pancreatitis and the presence of an inflammatory mass mainly in the pancreatic head in 1.2%, and in cancer of the pancreatic head in 5.9%. The mean preoperative NLR was normal in 33.8% of the patients, the mild physiologic stress level was 54.7%, and the moderate was 11.5% before surgery. 10.2% of patients had a normal nutritional status, 20% had mild, 19.6% had moderate, and 50.2% had severe malnutrition. In a univariate analysis, at the cutoff of NLR ≥ 9.5 (AUC = 0.803) and the cutoff of NRI ≤ 98.5 (AUC = 0.801), increasing the risk of complications was observed (hazard ratio, 2.01; 95% CI, 1.247–3.250, p = 0.006), but at the cutoff of NRI ≤ 83.55 (AUC = 0.81), we observed a survival difference in operated patients (hazard ratio, 2.15; 95% CI, 1.334–3.477, p = 0.0025). Conclusions Our study demonstrated that NLR and NRI were predictors of postoperative complications, but only NRI was a predictor of 90-day mortality in patients after surgery.

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Managing Organ Failure in Acute Pancreatitis

Ke,

Mao,

2024

Acute Pancreatitis

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Predicting persistent organ failure on admission in patients with acute pancreatitis: development and validation of a mobile nomogram

Cited by 5 publications

References 55 publications

Serum iron fluctuations link ferroptosis process with mortality and prognosis of acute pancreatitis

Serum iron fluctuations link ferroptosis process with mortality and prognosis of acute pancreatitis

Physiological stress level and screening for malnutrition as preoperative predictors of postoperative complications in pancreatic surgery: a retrospective study

Managing Organ Failure in Acute Pancreatitis

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