Predicting preterm delivery: comparison of cervicovaginal interleukin (IL)-1β, IL-6 and IL-8 with fetal fibronectin and cervical dilatation

Coleman, Matthew A.; Keelan, Jeffrey A.; McCowan, Lesley; Townend, K.; Mitchell, Murray D.

doi:10.1016/s0301-2115(00)00450-4

Cited by 53 publications

(37 citation statements)

References 23 publications

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“…However, one study, 219 which evaluated cervical IL-6 as predictor of spontaneous preterm birth in women who presented with symptoms of threatened preterm labour, was excluded because the author was not able to provide the data within the time constraint of the project. The number of women enrolled ranged from 73 103 to 290 220 with a median of 161 in asymptomatic women 221 and from 18 120 to 146 218 with a median of 73 in symptomatic women.…”

Section: Study Characteristics and Qualitymentioning

confidence: 99%

“…It can be found in amniotic fluid, cervical secretions and in maternal blood serum. Its presence in cervicovaginal secretions 219 or in increasing values in maternal serum 223 have been purported to predict spontaneous preterm birth in symptomatic women who presented with threatened preterm labour. …”

Section: Interleukin-8mentioning

confidence: 99%

“…Three potentially eligible studies for inclusion were excluded because data were unobtainable. 219,240,242 Appendix 5, Table 94 summarises each study's salient features, stratified according to the population of women tested, i.e. asymptomatic antenatal women (two studies) 243,244 and women with symptoms of threatened preterm labour (three studies).…”

Section: Study Characteristics and Qualitymentioning

confidence: 99%

“…The studies included in the review examined NSAIDs and COX inhibitors for treating threatened preterm labour. [595][596][597][598][599][600][601][602][603][604][605][606][607] Data were available on the following comparisons: 216,218,219,222,223,226,228,231,234 …”

Section: Figure 179 Forest Plot Of the Effects Of Betamimetics Versusmentioning

confidence: 99%

See 3 more Smart Citations

Screening to prevent spontaneous preterm birth: systematic reviews of accuracy and effectiveness literature with economic modelling

Honest

Ca²,

Durée³

et al. 2009

Health Technol Assess

189

146

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For primary prevention, an effective, affordable and safe intervention applied to all mothers without preceding testing is likely to be the most cost-effective approach in asymptomatic women in early pregnancy. For secondary prevention among women at risk of preterm labour in later pregnancy, a management strategy based on the results of testing is likely to be more cost-effective. Implementation of a treat-all strategy with simple interventions, such as fish oils, would be premature for asymptomatic women. Universal provision of high-quality ultrasound machines in labour wards is more strongly indicated for predicting spontaneous preterm birth among symptomatic women than direct management, although staffing issues and the feasibility and acceptability to mothers and health providers of such strategies need to be explored. Further research should include investigations of low-cost and effective tests and treatments to reduce and delay spontaneous preterm birth and reduce the risk of perinatal mortality arising from preterm birth.

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Section: Study Characteristics and Qualitymentioning

confidence: 99%

Section: Interleukin-8mentioning

confidence: 99%

Section: Study Characteristics and Qualitymentioning

confidence: 99%

Section: Figure 179 Forest Plot Of the Effects Of Betamimetics Versusmentioning

confidence: 99%

See 2 more Smart Citations

Screening to prevent spontaneous preterm birth: systematic reviews of accuracy and effectiveness literature with economic modelling

Honest

Ca²,

Durée³

et al. 2009

Health Technol Assess

189

146

View full text Add to dashboard Cite

show abstract

“…Among these, IL-6 demonstrates the greatest predictive value, since in asymptomatic women at 22-25 weeks its concentration in cervical fluid is significantly in case of subsequent PTD and in symptomatic women, affected by threatened PTD, it demonstrates ability to predict delivery within 2 and 7 days with a sensitivity and specificity of 60 and 77%, respectively, for predicting delivery within 2 days, and 62 and 80%, respectively, for predicting delivery within 7 days [106]. Furthermore, also in amniotic fluid, its concentration in asymptomatic women undergoing mid-trimester amniocentesis is higher in women with subsequent spontaneous PTD within 32 weeks of gestation, than those who delivered at term, showing an association of IL-6 levels in amniotic fluid and early PTD [107].…”

Section: Prognostic Toolsmentioning

confidence: 99%

The obstetric syndromes: clinical relevance of placental hormones

Severi

Bonis

Vellucci

et al. 2013

Expert Review of Endocrinology & Metabolism

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Preterm delivery, preeclampsia and intrauterine growth restriction are the major diseases of pregnancy. A key role in their pathogenesis is played by the placenta, which is the source of hormones and other important regulatory molecules providing the metabolic and endocrine homeostasis of the fetal-placental unit. Since obstetric syndromes are characterized by important maternal and neonatal morbidity and mortality worldwide, numerous efforts have been made over the years to prevent and treat them. Due to their complex pathogenesis, however, the therapy is poor and not very effective. Therefore, great emphasis is currently given to the prevention of these diseases through the identification of biochemical and biophysical markers, among which placental factors play a crucial role. The increasing knowledge of the role of placental molecules can indeed lead to the development of new therapeutic and diagnostic tools. The obstetric syndromes: clinical relevance of placental hormonesExpert Rev. Endocrinol. Metab. 8(2), 127-138 (2013)

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Pathogenesis and Prediction of Preterm Delivery

Buhimschi

Lockwood

2007

Management of High‐Risk Pregnancy

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Predicting preterm delivery: comparison of cervicovaginal interleukin (IL)-1β, IL-6 and IL-8 with fetal fibronectin and cervical dilatation

Cited by 53 publications

References 23 publications

Screening to prevent spontaneous preterm birth: systematic reviews of accuracy and effectiveness literature with economic modelling

Screening to prevent spontaneous preterm birth: systematic reviews of accuracy and effectiveness literature with economic modelling

The obstetric syndromes: clinical relevance of placental hormones

Pathogenesis and Prediction of Preterm Delivery

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