Predicting risk for bisphosphonate-related osteonecrosis of the jaws: CTX versus radiographic markers

Fleisher, Kenneth E.; Welch, Garrett; Kottal, Shailesh; Craig, Ronald G.; Saxena, Deepak; Glickman, Robert

doi:10.1016/j.tripleo.2010.04.023

Cited by 84 publications

(72 citation statements)

References 76 publications

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“…9 However, many studies have not confirmed the effectiveness of this test for patients with cancer or osteoporosis. [33][34][35][36] The retrospective nature of the present study is counterbalanced by the larger sample of cases of surgical treatment of BRONJ than reported in the rest of the literature. However, further research based on prospective studies is needed to clarify these findings.…”

Section: Discussionmentioning

confidence: 91%

Resective Surgical Approach Shows a High Performance in the Management of Advanced Cases of Bisphosphonate-Related Osteonecrosis of the Jaws: A Retrospective Survey of 347 Cases

Graziani

Vescovi

Campisi

et al. 2012

Journal of Oral and Maxillofacial Surgery

117

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Purpose:The aim of this study was to evaluate the results of the surgical treatment of bisphosphonaterelated osteonecrosis of the jaw (BRONJ) in a large cohort. Materials and Methods: A retrospective cohort multicenter study was designed. Patients were enrolled if they were diagnosed with BRONJ and received operative treatment. Data on demographic, health status, perioperative, and surgical factors were collected retrospectively. The primary outcome variable was a change in BRONJ staging (improvement, worsening, or no change). Interventions were grouped by local debridement and resective surgery. Data were collected for other variables as cofactors. Univariate analysis and logistic regressions were then performed. Results: Of the 347 BRONJ-affected subjects, 59% showed improvement, 30% showed no change, and 11% showed worsening. Improvement was observed in 49% of cases treated with local debridement and 68% of cases treated with resective surgery. Multivariate analysis indicated that maxillary location, resective surgery, and no additional corticosteroid treatment were associated with a positive outcome. Conclusions: Surgical treatment of BRONJ appeared to be more effective when resective procedures were performed. Nonetheless, other factors, such as the absence of symptoms and the types of drug administration, should be taken into account before clinical decisions are made.

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Section: Discussionmentioning

confidence: 91%

Resective Surgical Approach Shows a High Performance in the Management of Advanced Cases of Bisphosphonate-Related Osteonecrosis of the Jaws: A Retrospective Survey of 347 Cases

Graziani

Vescovi

Campisi

et al. 2012

Journal of Oral and Maxillofacial Surgery

117

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show abstract

“…Además, existe una alta diversidad de la microbiota oral siendo el ambiente ideal para una rápida proliferación bacteriana (4,15). La primera exposición ósea después de la administración de bifosfonatos es de aproximadamente 14,3 meses (pamidronato), 12,1 meses (pamindronato y zoledronato), 9,4 meses(zoledronato) y después de 36 meses (alendronato) (3,4,6,20).…”

Section: Incidenciaunclassified

Osteonecrosis de los maxilares: fisiopatología, diagnóstico y tratamiento

Cortés-Motta¹,

Grisales²

2016

CES odontol.

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“…The classic reported anti-resorptive agent changes are sclerotic. Sclerotic changes may be seen in many fashions but a classic feature would be extraction sockets appearing radiopaque [55]. The sequestrum may also be well appreciated on 3-D imaging such as cone beam CTs (Fig.…”

Section: Radiographic Featuresmentioning

confidence: 99%