Predicting skin permeability using liposome electrokinetic chromatography

Wang, Yongjun; Sun, Jin; Liu, Hongzhuo; Liu, Jianfang; Zhang, Liqiang; Li, Kai; Zhang, He

doi:10.1039/b807497f

Cited by 29 publications

(18 citation statements)

References 35 publications

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“…Recently, it was demonstrated that LEKC is a promising method to predict drug penetration through the skin. Quantitative retention-permeability relationships (QRPeRs) were successfully constructed between skin permeability coefficients (log K p ) and retention values (log k) (118).…”

Section: Liposome Electrokinetic Chromatography (Lekc)mentioning

confidence: 99%

Lipophilicity and Its Relationship with Passive Drug Permeation

2010

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In this review, we first summarize the structure and properties of biological membranes and the routes of passive drug transfer through physiological barriers. Lipophilicity is then introduced in terms of the intermolecular interactions it encodes. Finally, lipophilicity indices from isotropic solvent systems and from anisotropic membrane-like systems are discussed for their capacity to predict passive drug permeation across biological membranes such as the intestinal epithelium, the blood-brain barrier (BBB) or the skin. The broad evidence presented here shows that beyond the predictive power of lipophilicity parameters, the various intermolecular forces they encode allow a mechanistic interpretation of passive drug permeation.

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Section: Liposome Electrokinetic Chromatography (Lekc)mentioning

confidence: 99%

Lipophilicity and Its Relationship with Passive Drug Permeation

2010

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“…The systems include the immobilized artificial membrane (Barbato et al, 1998), biopartitioning micellar chromatography (Escuder-Gilabert et al, 2003;Waters et al, 2013), liposome electrokinetic chromatography (Wang et al, 2009), and keratin immobilized on the silica as a stationary phase (Turowski and Kaliszan, 1997). However, in respect to the optimization of the formulation destined for the administration onto the skin, the effects of various additives and carriers/vehicles on the drug penetration, these chromatographic systems exhibit a very limited potential and are therefore not further discussed in this review.…”

Section: Artificial In Vitro Skin Modelsmentioning

confidence: 99%

In vitro skin models as a tool in optimization of drug formulation

Flaten

Palac²,

Engesland

et al. 2015

European Journal of Pharmaceutical Sciences

182

135

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Abstract(Trans)dermal drug therapy is gaining increasing importance in the modern drug development. To fully utilize the potential of this route, it is important to optimize the delivery of active ingredient/drug into/through the skin. The optimal carrier/vehicle can enhance the desired outcome of the therapy therefore the optimization of skin formulations is often included in the early stages of the product development. A rational approach in designing and optimizing skin formulations requires well-defined skin models, able to identify and evaluate the intrinsic properties of the formulation. Most of the current optimization relies on the use of suitable ex vivo animal/human models.However, increasing restrictions in use and handling of animals and human skin stimulated the search for suitable artificial skin models. This review attempts to provide an unbiased overview of the most commonly used models, with emphasis on their limitations and advantages. The choice of the most applicable in vitro model for the particular purpose should be based on the interplay between the availability, easiness of the use, cost and the respective limitations.

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“…Measurements and computations indicated that a good linear correlation can established between the retention behavior of the analytes and their skin permeation capacity. The method was proposed for the prediction of drug permeation through the skin (Wang et al, 2009a;Wang et al, 2009b).…”

Section: Liposome Electrokinetic Capillary Chromatographymentioning

confidence: 99%

Liposomes in chromatography

Cserháti

Szőgyi

2010

Biomedical Chromatography

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The newest achievements in the application of liposomes in different chromatographic technologies such as high-performance liquid chromatography and electrically driven separation methods was compiled and critically evaluated. The employment of chromatographic methodologies for the determination of molecular parameters of biological importance is also discussed in detail. The future trends of the use of liposomes is also shortly discussed.

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Predicting skin permeability using liposome electrokinetic chromatography

Cited by 29 publications

References 35 publications

Lipophilicity and Its Relationship with Passive Drug Permeation

Lipophilicity and Its Relationship with Passive Drug Permeation

In vitro skin models as a tool in optimization of drug formulation

Liposomes in chromatography

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