Predicting Subsequent Visual Field Loss in Glaucomatous Subjects With Disc Hemorrhage Using Retinal Nerve Fiber Layer Polarimetry

Abstract

Wavelet-Fourier analysis can differentiate progressors from non-progressors with moderate accuracy. Comparison to a prior study of this same cohort emphasizes that relatively small regions must be considered (as opposed to larger quadrants) to see these significant changes in RNFL.

The utility of relative afferent pupillary defect as a screening tool for glaucoma: prospective examination of a large population-based study in a south Indian population

“…It is also important to realise that there are many other diseases aside from glaucoma that may lead to an APD. This limitation, combined with the known poor sensitivity and specificity of optic disc cupping,19 disc haemorrhage20 and IOP,21 leads us to conclude that APD measured by the swinging flashlight test alone would not be a helpful screening tool.…”

Comparison of Shape-based Analysis of Retinal Nerve Fiber Layer Data Obtained From OCT and GDx-VCC

“…In the present study (see also Refs. 20,21,25,28,41), principal component analysis (PCA) is then used to optimize the feature space (resulting in 11 features). A linear discriminant analysis (Fisher) is then performed and the resulting linear discriminant function (LDF) is used as a classifier.…”

“…The shape-based analysis methods have been shown to improve both GDx-VCC 20,[23][24][25]28 and OCT performance 21,23 over the standard output metrics; however, they have not previously been directly compared in the same population and thus it is not presently known whether GDx-VCC with a shape-based metric or OCT with a shape-based metric is superior. Here we obtain these measures on the same sample of eyes to address this question.…”

“…20,21 For this reason, metrics derived from measures of local thickness are now used 20-28 more often than measures of average thickness over large regions or angles. One method 20,21,[23][24][25]28 analyzes the shape of the pattern of thicknesses around the disc, that is, the shape of the temporal, superior, nasal, inferior, temporal (TSNIT) thickness curve (360 degrees of measurements in the order of: temporal, superior, nasal, inferior, and temporal). This method analyzes the TSNIT thickness curve by applying either a Fourier analysis or wavelet analysis to parameterize the shape of this curve.…”

Correlation between blue-on-yellow perimetry and scanning laser polarimetry with variable corneal compensation measurements in primary open-angle glaucoma

“…Previous works have demonstrated that GDx VCC is a fast, highly sensitive, and highly specifi c method for detecting RNFL defects and monitoring local RNFL changes in glaucoma. [17][18][19][20][21] Georgopoulos et al 22 found that ocular hypertension and B/YP visual fi eld defects frequently coexist in eyes and that the latter correspond to RNFL abnormalities detected by scanning laser polarimetry. However, in some eyes, the two methods detect different glaucoma properties.…”