Predicting success of intrauterine insemination using a clinically based scoring system

Zippl, Anna Lena; Wachter, Alfons; Rockenschaub, Patrick; Tóth, Bettina; Seeber, Beata

doi:10.1007/s00404-022-06758-z

Cited by 3 publications

(3 citation statements)

References 55 publications

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“…Our study advocated for a maximum of four consecutive IUI cycles to optimize the probability of pregnancy, a suggestion consistent with certain literature advocating for cycle limits (Zippl et al, 2022).…”

Section: Cumulative Pregnancy Ratessupporting

confidence: 84%

Unlocking fertility success: A comprehensive exploration of age and intrauterine insemination outcomes

Mohammed Mosa,

Saud Aburasyin,

Ahmed Aljishi

et al. 2024

Med Sci

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Background: The success of intrauterine insemination (IUI) can be influenced by multiple factors, extending beyond age and the number of treatment cycles. Objectives: This study aims to conduct a thorough analysis of 466 IUI treatment cycles performed on 221 patients at a fertility center within a university hospital between 2021 and 2023. Methods: A retrospective review of medical records was conducted, encompassing 466 IUI treatment cycles performed on 221 patients at a university hospital's fertility center from 2021 to 2023. Female patients were categorized into three age groups: below 35 years old, between 35 and 40 years old, and over 40 years old. The study evaluated multiple outcomes, including rates of biochemical pregnancy, clinical pregnancy, live births, and miscarriages. A Kaplan-Meier analysis was employed to assess treatment cycle success within each age group. Results: The average age of the patients was 35.2 years, ranging from 21 to 49 years. The overall rate of biochemical pregnancy was 69.6%. Biochemical pregnancy rates significantly declined with increasing female age, with rates of 45.6% for those below 35 years old, 39.8% for those aged 35 to 40 years, and 34.1% for those over 40 years old (p = 0.002). However, there were no significant differences observed in other pregnancy outcomes across different age groups. The cumulative biochemical pregnancy rate increased up to four cycles in all age groups. Conclusion: It is recommended to consider up to four insemination cycles before proceeding to an IVF/ICSI cycle.

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Section: Cumulative Pregnancy Ratessupporting

confidence: 84%

Unlocking fertility success: A comprehensive exploration of age and intrauterine insemination outcomes

Mohammed Mosa,

Saud Aburasyin,

Ahmed Aljishi

et al. 2024

Med Sci

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“…Spermiogram parameters play a crucial role in assessing couples' suitability for an IUI cycle, continuously attracting research attention and clinical interest. However, previous reports indicated that no universally accepted parameter from pre-wash or post-wash semen analyses reliably predicts the outcome of IUI treatment [22][23][24][25]. In our study, patients with a post-wash TPMSC of <1 × 10 6 were not included.…”

Section: Discussionmentioning

confidence: 97%

Is There Any Effect of Change in Pre-Wash and Post-Wash Semen Parameters on the Success of Intrauterine Insemination?

Yavuzcan,

Yurtçu,

Keyif

et al. 2023

JPM

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(1) Background: We aimed to investigate the effect of change in pre-wash and post-wash semen parameters on intrauterine insemination (IUI) success in a homogenous study group. (2) Methods: IUI cycles conducted at an infertility clinic were included in this study. Patient records were examined retrospectively. Δ sperm count (per mL) was calculated as [pre-wash sperm count (per mL)–post-wash sperm count (per mL)]. Δ Total progressive motile sperm count (TPMSC) was also calculated as (post-wash TPMSC-pre-wash TPMSC). (3) Results: No statistically significant difference was detected in terms of Δ sperm count (p = 0.38), and Δ TPMSC (p = 0.76) regarding the clinical pregnancy rate (CPR). There was no statistically significant difference between CPR (+) and CPR (−) groups in terms of post-wash sperm count, TPMSC, TPMSC ≥ 10 × 10⁶, TPMSC ≥ 5 × 10⁶ (p = 0.65, p = 0.79, p = 0.49, p = 0.49, respectively). The live birth rate (LBR) showed no statistically significant differences except for a pre-wash TPMSC ≥ 10 × 10⁶ (p = 0.02). Through the performed ROC analysis, no statistically significant cutoff value could be set for the pre-wash TPMSC. (4) Conclusions: There is only a pre-wash TPMSC ≥ 10 × 10⁶ that showed a significant role in the success of IUI, even when considering all other pre-wash and post-wash semen parameters. Δ sperm count and Δ are not useful markers for IUI success.

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“…Patient drop-off or unwillingness to return after initial cycle failure represents a significant limitation in modern IVF, and the major physical, emotional, and financial burdens women undergo for treatment are important contributors to this drop-off. While less invasive options such as intrauterine insemination (IUI) may be successful for some, the success rates are extraordinarily low, with some studies showing a clinical pregnancy rate of 10% or less per cycle and pose inherent challenges in same-sex couples who wish to utilize reciprocal IVF treatment (43). This study shows that minimal COS plus OSC-IVM is highly tolerated and potentially similarly efficacious compared to conventional COS, with higher satisfaction and willingness to repeat.…”

Section: Discussionmentioning

confidence: 99%

Donor side effects experienced under minimal controlled ovarian stimulation (COS) with in vitro maturation (IVM) versus conventional COS forin vitrofertilization (IVF) treatment

Marchante,

Barrachina,

Piechota

et al. 2024

Preprint

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Objective: To evaluate how minimal controlled ovarian stimulation (COS) for in vitro maturation (IVM) affects subjects' oocyte retrieval experiences compared to conventional COS, considering side effects Design: Retrospective Survey Study Setting: Clinical in vitro fertilization (IVF) treatment centers in Spain and the United States. Subjects: Data were collected from subjects undergoing minimal COS (n=110; 600-800 IU FSH) for IVM and conventional COS for egg donation (n=48; 2000-3000 IU FSH) from April 2022 to November 2023. In the same period, a pairwise comparison of subjects (n=13) undergoing both minimal COS for IVM and conventional COS for oocyte cryopreservation was conducted. Intervention/Exposure: Minimal and conventional controlled ovarian stimulation. Main Outcome Measures: The most common side effects suffered during ovarian stimulation and after OPU, satisfaction level, and the likelihood of recommending or repeating minimal or conventional COS. Statistical analysis included Mann Whitney, Wilcoxon, Chi-square, and McNemar tests, with a significance level set at p<0.05. Results: During minimal COS, most subjects did not experience breast swelling (86%), pelvic or abdominal pain (76%), nausea or vomiting (96%), and bleeding (96%). After oocyte pick-up, the majority (75%) reported no pelvic or abdominal pain. The most common side effect was abdominal swelling (52%). Compared to conventional COS cycles, minimal COS subjects reported significantly less post-retrieval pain, with 33% experiencing no pain (vs. 6%; p=0.0011) and with a reduced severe level of pain (5% vs.19%; p=0.0097), leading to fewer subjects requiring pain medication (25% vs. 54%; p=0.0003). Additionally, 85% of women were very satisfied with minimal stimulation and would recommend or repeat the treatment. In the comparison in which each donor underwent both minimal and conventional COS treatments, women indicated more side effects with the conventional stimulation, presenting a significantly overall higher level of pain (p=0.0078). Conclusion: Reducing the hormonal dose for ovarian stimulation has a beneficial effect on subjects, suggesting the combination of minimal COS with IVM techniques is a well-tolerated alternative for women who cannot or do not wish to undergo conventional controlled ovarian hyperstimulation.

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Predicting success of intrauterine insemination using a clinically based scoring system

Cited by 3 publications

References 55 publications

Unlocking fertility success: A comprehensive exploration of age and intrauterine insemination outcomes

Unlocking fertility success: A comprehensive exploration of age and intrauterine insemination outcomes

Is There Any Effect of Change in Pre-Wash and Post-Wash Semen Parameters on the Success of Intrauterine Insemination?

Donor side effects experienced under minimal controlled ovarian stimulation (COS) with in vitro maturation (IVM) versus conventional COS forin vitrofertilization (IVF) treatment

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