Predicting the invasion depth of esophageal squamous cell carcinoma: comparison of endoscopic ultrasonography and magnifying endoscopy

Mw, Lee; Gh, Kim; Dy, Park; Dh, Baek; Be, Lee; Ga, Song

doi:10.3109/00365521.2014.915052

Cited by 36 publications

(38 citation statements)

References 39 publications

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“…However, in the present study, accuracy of the JES classification was 78.6%, which is similar to the results of our previous study using Inoue’s classification[18]. Recently, a prospective multicenter study using the JES classification in Japan also demonstrated a high overall accuracy rate (90.5%) for type B vessels[16].…”

Section: Discussionsupporting

confidence: 89%

“…It has been reported that m3 to sm1 cancers without lymphovascular invasion have very low risk of LN metastasis[3,19], and, as such, are potential candidates for curative treatment by endoscopic resection. Thus, because it is important to detect underestimated sm2 cancers in type B2 tumors, additional use of endoscopic ultrasonography or another diagnostic modality to estimate depth of invasion may be helpful[18]. …”

Section: Discussionmentioning

confidence: 99%

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New magnifying endoscopic classification for superficial esophageal squamous cell carcinoma

Kim

Lee

et al. 2017

WJG

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AIMTo assess the accuracy of a new magnifying endoscopy (ME) classification for predicting depth of invasion of superficial esophageal squamous cell carcinoma (SESCC).METHODSThis study included a total of 70 lesions in 69 patients with SESCC who underwent ME with narrow-band imaging (ME-NBI) before resection from August 2010 to July 2016. Accuracy of ME-NBI for predicting depth of invasion of SESCC was analyzed by using a new ME classification proposed by the Japan Esophageal Society (JES), and interobserver agreement was assessed.RESULTSOverall accuracy of ME-NBI for estimating depth of invasion of SESCC was 78.6%. Sensitivity and specificity of type B1 for tumors limited to the epithelial layer (m1) or invading into the lamina propria (m2) were 71.4% and 100%, respectively. Sensitivity and specificity of type B2 for tumors invading into the muscularis mucosa (m3) or superficial submucosa (≤ 200 μm, sm1) were 94.4% and 73.1%, respectively, while those of type B3 for tumors invading into the deep submucosa (> 200 μm, sm2) were 75.0% and 97.8%, respectively. Interobserver agreement was excellent (κ = 0.86, 95%CI: 0.76-0.95).CONCLUSIONThe recently developed JES ME classification is useful for predicting depth of invasion of SESCC, with reliable interobserver agreement.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

New magnifying endoscopic classification for superficial esophageal squamous cell carcinoma

Kim

Lee

et al. 2017

WJG

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“…However, there was no standardized methodology or definition of depth. In some articles, the authors simply used two subclassifications: mucosa (M) and submucosa (SM) and, in other articles, the authors divided the depth of superficial cancer into three or six subclassifications according to the Japanese Classification of Esophageal cancer…”

Section: Current Status In China Korea Japan and Taiwanmentioning

confidence: 99%

“…In articles from these four countries, EUS accuracy for depth assessment of superficial esophageal cancer ranged from approximately 59.1% to 92.0% [4][5][6][7][8][9][10][11][12] (Table 1). However, there was no standardized methodology or definition of depth.…”

Section: Is Eus Useful In Assessing the Depth Of Involvement Of Supermentioning

confidence: 99%

Current status of endoscopic ultrasound for the upper gastrointestinal tract in Asia

Yoshinaga

Hilmi

Kwek

et al. 2015

Digestive Endoscopy

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We summarize the current status of endoscopic ultrasound (EUS) for the upper gastrointestinal (GI) tract solely in Asia, focusing on the staging of superficial cancers and the diagnosis of submucosal tumors (SMT), by analysis of questionnaire responses and a literature review. EUS for assessing the depth of superficial cancers of the upper GI tract is useful; however, evidence is lacking to support that EUS is superior to other modalities. The current status of EUS varies across different Asian countries, and standardization of the methods used both during the procedure and for depth subclassification is necessary to evaluate the diagnostic accuracy. Although EUS alone is limited in the diagnosis of SMT, EUS-guided fine-needle aspiration is an effective and safe diagnostic tool. Although there is a role for EUS, there are still many limitations both technically and in terms of accessibility.

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“…Another technique, magnifying endoscopy (ME), especially using narrow‐band imaging, enables the examination of intrapapillary capillary loops (IPCLs) within the esophageal mucosa, which works as an indicator of the histopathologic grade of the SESNs . ME also enables a prediction of the depth of superficial esophageal lesions, based on IPCL pattern changes . Therefore, biopsies can be performed that target the portions of the lesions with the most invasive histopathology, based on the observed IPCL patterns.…”

Section: Discussionmentioning

confidence: 99%

Histopathologic discrepancies between endoscopic forceps biopsy and endoscopic resection specimens in superficial esophageal squamous neoplasms

Park

Kim

Park

et al. 2019

J of Gastro and Hepatol

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Background and Aim Endoscopic forceps biopsy results that reflect the final pathologic results of an entire lesion are essential for making accurate diagnoses and appropriate therapeutic decisions for patients with superficial esophageal squamous neoplasms (SESNs). This study investigated the histopathologic discrepancies between endoscopic forceps biopsy and endoscopic resection specimens to elucidate the factors contributing to such discrepancies. Methods This retrospective observational study involved 77 patients (84 lesions) who underwent endoscopic resections for SESNs, between January 2005 and August 2017, at the Pusan National University Hospital. The SESNs were classified as low‐grade intraepithelial neoplasms (LGINs), high‐grade intraepithelial neoplasms (HGINs), or squamous cell carcinomas (SCCs). Following slide reviews, the histopathologic concordance between endoscopic forceps biopsy and endoscopic resection specimens was assessed, in each case. Results The histopathologic discrepancy rate between the endoscopic forceps biopsy and endoscopic resection specimens was 34.5% (29/84 lesions). Among the 29 diagnostically discordant lesions, upgrades and downgrades of the histopathologic diagnoses occurred for 27 and 2 lesions, respectively. The predominant discrepancies results in lesion upgrades from HGIN to SCC (n = 21) and from LGIN to SCC (n = 5). The two downgraded cases included one from SCC to HGIN and one from HGIN to LGIN. Multivariate analyses identified two factors that were significantly associated with the histopathologic discrepancies: upper esophageal location (odds ratio, 7.743; 95% confidence interval, 1.031–58.174; P = 0.047) and tumor area per biopsy ≥ 158.6 mm2/biopsy (odds ratio, 5.933; 95% confidence interval, 1.051–44.483; P = 0.044). Conclusion Histopathologic discrepancies were observed between endoscopic forceps biopsy and endoscopic resection specimens in patients with SESNs. Tumor location and tumor area/biopsy were both significantly associated with the discrepancies.

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Predicting the invasion depth of esophageal squamous cell carcinoma: comparison of endoscopic ultrasonography and magnifying endoscopy

Cited by 36 publications

References 39 publications

New magnifying endoscopic classification for superficial esophageal squamous cell carcinoma

New magnifying endoscopic classification for superficial esophageal squamous cell carcinoma

Current status of endoscopic ultrasound for the upper gastrointestinal tract in Asia

Histopathologic discrepancies between endoscopic forceps biopsy and endoscopic resection specimens in superficial esophageal squamous neoplasms

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