2004
DOI: 10.1093/eurheartj/ehi037
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Predicting the risk of early atherosclerotic disease development in children after repair of aortic coarctation

Abstract: This study documents early vascular wall changes in children after successful coarctation repair. Arterial hypertension and a resting pressure gradient are the major contributing factors to early atherosclerotic development and should be primary targets for therapy. Vascular status should be monitored regularly by FMD and IMT.

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Cited by 84 publications
(67 citation statements)
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“…The triangular-shaped morphology of the gothic arch could simply reflect the systolic wave inducing an early remodeling of the aortic wall. This is also confirmed by the evidence of morpho-functional alterations of the conduit arteries proximal to the AoCo repair site [14][15][16][17] , which are independent from time of intervention [18][19][20] . An increased resistance to pulsed wave propagation across the arch has been documented in the gothic arch shape group 6 .…”
supporting
confidence: 57%
“…The triangular-shaped morphology of the gothic arch could simply reflect the systolic wave inducing an early remodeling of the aortic wall. This is also confirmed by the evidence of morpho-functional alterations of the conduit arteries proximal to the AoCo repair site [14][15][16][17] , which are independent from time of intervention [18][19][20] . An increased resistance to pulsed wave propagation across the arch has been documented in the gothic arch shape group 6 .…”
supporting
confidence: 57%
“…Even in children after coarctation repair an increased intima media thickness as early sign of atherosclerosis could be detected. (13) In the Mayo Clinic study of 1989, coronary artery disease was the most common cause of late postoperative death. (44) Thoracic musculoskeletal sequelae…”
Section: Coronary Artery Diseasementioning
confidence: 99%
“…(8,10) Furthermore, an increased carotid intima-media thickness was found in young adults (11,12) and children (13) with CoA, as well as a diminished endothelium dependent and independent vasodilatation in the right brachial artery. (10,(13)(14)(15) …”
mentioning
confidence: 92%
“…Notwithstanding the relatively early introduction of effective CoAo surgical treatment in 1944 [6] and a further successful implementation of transcatheter approach in 1982 [7], longterm outcome is still compromised on account of the process of arterial remodeling in pre-stenotic vascular bed, associated with arterial stiffness [8][9][10][11] and baroreceptor dysfunction [12]. The resultant markedly increased prevalence of arterial hypertension of 30-50%, regarded as a hallmark of CoAo [13][14], leads to diffuse atherosclerosis [11,[15][16][17] and notably reduced life expectancy [18][19]. Yet, even normotensive CoAo patients exhibit both functional and structural vascular abnormalities [15,[20][21].…”
Section: Introductionmentioning
confidence: 99%
“…The resultant markedly increased prevalence of arterial hypertension of 30-50%, regarded as a hallmark of CoAo [13][14], leads to diffuse atherosclerosis [11,[15][16][17] and notably reduced life expectancy [18][19]. Yet, even normotensive CoAo patients exhibit both functional and structural vascular abnormalities [15,[20][21]. Data concerning optimal timing of surgery is inconsistent, with the predominance of reports implying improved long-term outcome in patients operated within the first year after birth [22][23][24].…”
Section: Introductionmentioning
confidence: 99%