Predicting tumor recurrence using metabolic indices of 18F‑FDG PET/CT prior to orthotopic liver transplantationfor hepatocellular carcinoma

Ding, Enci; Lu, Dunyue; Wei, Lijuan; Feng, Xiaoli; Shen, Jie; Xu, Wengui

doi:10.3892/ol.2020.11681

Cited by 8 publications

(7 citation statements)

References 42 publications

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“…Some novel indicators have been investigated for integration with AFP, such as 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) 131,132 and plasma metabolomics profiling 133 . In addition, several criteria established and validated previously were combined with AFP for the purpose of minimizing the risk of post-LT tumor recurrence 134,135 .…”

Section: Afp With Other Factorsmentioning

confidence: 99%

The Landscape Of Alpha Fetoprotein In Hepatocellular Carcinoma: Where Are We?

Hu¹,

Chen²,

Wei³

et al. 2022

Int. J. Biol. Sci.

100

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Hepatocellular carcinoma (HCC) is the most common primary liver cancer and has been acknowledged as a leading cause of death among cirrhosis patients. Difficulties in early diagnosis and heterogeneity are obstacles to effective treatment, especially for advanced HCC. Liver transplantation (LT) is considered the best therapy for HCC. Although many biomarkers are being proposed, alpha-fetoprotein (AFP), which was identified over 60 years ago, remains the most utilized. Recently, much hope has been placed in the immunogenicity of AFP to develop novel therapies, such as AFP vaccines and AFP-specific adoptive T-cell transfer (ACT). This review summarizes the performance of AFP as a biomarker for HCC diagnosis and prognosis, as well as its correlation with molecular classes. In addition, the role of AFP in LT is also described. Finally, we highlight the mechanism and application prospects of two immune therapies (AFP vaccine and ACT) for HCC. In general, our review points out the prevalence of AFP in HCC, accompanied by some controversies and novel directions for future research.

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Section: Afp With Other Factorsmentioning

confidence: 99%

The Landscape Of Alpha Fetoprotein In Hepatocellular Carcinoma: Where Are We?

Hu¹,

Chen²,

Wei³

et al. 2022

Int. J. Biol. Sci.

100

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“…However, MTV from the pre-treatment 18 F-FDG PET/CT has shown to be prognostic in patients treated with selective internal radiation therapy (SIRT) with yttrium-90 for unresectable CRLM and resection for CRLM [ 24 – 27 ]. Several studies have shown that MTV derived from 18 F-FDG PET/CT can predict recurrence and survival after LT for HCC [ 28 , 29 ].…”

Section: Discussionmentioning

confidence: 99%

Metabolic tumor volume predicts long-term survival after transplantation for unresectable colorectal liver metastases: 15 years of experience from the SECA study

et al. 2022

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Objective To report 15 years of experience with metabolic tumor volume (MTV) of liver metastases from the preoperative 18F-FDG PET/CT to predict long-term survival after liver transplantation (LT) for unresectable colorectal liver metastases (CRLM). Methods The preoperative 18F-FDG PET/CT from all SECA 1 and 2 patients was evaluated. MTV was obtained from all liver metastases. The patients were divided into one group with low MTV (< 70 cm3) and one group with high MTV (> 70 cm3) based on a receiver operating characteristic analysis. Overall survival (OS), disease-free survival (DFS) and post recurrence survival (PRS) for patients with low versus high MTV were compared using the Kaplan–Meier method and log rank test. Clinopathological features between the two groups were compared by a nonparametric Mann–Whitney U test for continuous and Fishers exact test for categorical data. Results At total of 40 patients were included. Patients with low MTV had significantly longer OS (p < 0.001), DFS (p < 0.001) and PRS (p = 0.006) compared to patients with high values. The patients with high MTV had higher CEA levels, number of liver metastases, size of the largest liver metastasis, N-stage, number of chemotherapy lines and more frequently progression of disease at LT compared to the patients with low MTV. Conclusion MTV of liver metastases is highly predictive of long-term OS, DFS and PRS after LT for unresectable CRLM and should be implemented in risk stratification prior to LT.

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“…It has been shown previously that tumor number positively related to the incidence of MVI, and frequency of MVI dramatically increased as tumor number increased. [26][27][28] Elevated AST level has been investigated as a detrimental factor on prognosis for HCC patients, which reflects liver burden and may indicate anti-aggressiveness of liver to some extent. 29,30 To our knowledge, few studies found AST as an independent predictor of MVI, AST was identified as independent predictor of MVI for HCC patients in our current study.…”

Section: Discussionmentioning

confidence: 99%

Preoperative Radiomics Analysis of Contrast-Enhanced CT for Microvascular Invasion and Prognosis Stratification in Hepatocellular Carcinoma

Xu¹,

Ren²,

Liao³

et al. 2022

JHC

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Microvascular invasion (MVI) impairs long-term prognosis of patients with hepatocellular carcinoma (HCC). We aimed to develop a novel nomogram to predict MVI and patients' prognosis based on radiomic features of contrast-enhanced CT (CECT). Patients and Methods: HCC patients who underwent curative resection were enrolled. The radiomic features were extracted from the region of tumor, and the optimal MVI-related radiomic features were selected and applied to construct radiomic signature (Radscore). The prediction models were created according to the logistic regression and evaluated. Biomarkers were analyzed via q-PCR from randomly selected HCC patients. Correlations between biomarkers and radiomic signature were analyzed. Results: A total of 421 HCC patients were enrolled. A total of 1962 radiomic features were extracted from the region of tumor, and the 11 optimal MVI-related radiomic features showed a favor predictive ability with area under the curves (AUCs) of 0.796 and 0.810 in training and validation cohorts, respectively. Aspartate aminotransferase (AST), tumor number, alpha-fetoprotein (AFP) level, and radiomics signature were independent risk factors of MVI. The four factors were integrated into the novel nomogram, named as CRM, with AUCs of 0.767 in training cohort and 0.793 in validation cohort for predicting MVI, best among radiomics signature alone and clinical model. The nomogram was well-calibrated with favorable clinical value demonstrated by decision curve analysis and can divide patients into high-or low-risk subgroups of recurrence and mortality. In addition, gene BCAT1, DTGCU2, DOCK3 were analyzed via q-PCR and serum AFP were identified as having significant association with radiomics signature. Conclusion:The novel nomogram demonstrated good performance in preoperatively predicting the probability of MVI, which might guide clinical decision.

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Predicting tumor recurrence using metabolic indices of 18F‑FDG PET/CT prior to orthotopic liver transplantationfor hepatocellular carcinoma

Cited by 8 publications

References 42 publications

The Landscape Of Alpha Fetoprotein In Hepatocellular Carcinoma: Where Are We?

The Landscape Of Alpha Fetoprotein In Hepatocellular Carcinoma: Where Are We?

Metabolic tumor volume predicts long-term survival after transplantation for unresectable colorectal liver metastases: 15 years of experience from the SECA study

Preoperative Radiomics Analysis of Contrast-Enhanced CT for Microvascular Invasion and Prognosis Stratification in Hepatocellular Carcinoma

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