Prediction and enrichment analyses of the <i>Homo sapiens-Drosophila melanogaster</i> COPD-related orthologs: potential for modeling of human COPD genomic responses with the fruit fly

Rouka, Erasmia; Gourgoulianni, Natalia; Lüpold, Stefan; Hatzoglou, Chrissi; Gourgoulianis, Konstantinos; Zarogiannis, Sotirios G.

doi:10.1152/ajpregu.00092.2021

Cited by 4 publications

(2 citation statements)

References 42 publications

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“…Combining the excellent genetic amenability with the conservation of key organ systems [143,144], Drosophila has a strong history in modelling a myriad of human diseases (see https://www.sdbonline.org/sites/fly/modelsystem/aamodelsystem.htm, accessed on 18 August 2023 for a comprehensive summary, or [145][146][147][148][149][150][151][152][153]). These attributes can also be applied to the study of pathogenesis caused by the dysregulation of RNP granules at a molecular, cellular, tissue, and organismal level.…”

Section: Using Drosophila As a Model To Understand The Role Of P Bodi...mentioning

confidence: 99%

Relating the Biogenesis and Function of P Bodies in Drosophila to Human Disease

Wilby,

Weil

2023

Genes

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Drosophila has been a premier model organism for over a century and many discoveries in flies have furthered our understanding of human disease. Flies have been successfully applied to many aspects of health-based research spanning from behavioural addiction, to dysplasia, to RNA dysregulation and protein misfolding. Recently, Drosophila tissues have been used to study biomolecular condensates and their role in multicellular systems. Identified in a wide range of plant and animal species, biomolecular condensates are dynamic, non-membrane-bound sub-compartments that have been observed and characterised in the cytoplasm and nuclei of many cell types. Condensate biology has exciting research prospects because of their diverse roles within cells, links to disease, and potential for therapeutics. In this review, we will discuss processing bodies (P bodies), a conserved biomolecular condensate, with a particular interest in how Drosophila can be applied to advance our understanding of condensate biogenesis and their role in disease.

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Section: Using Drosophila As a Model To Understand The Role Of P Bodi...mentioning

confidence: 99%

Relating the Biogenesis and Function of P Bodies in Drosophila to Human Disease

Wilby,

Weil

2023

Genes

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“…A better understanding of the etiology of COPD could provide a stimulating source of information concerning the prevention and treatment of the disease and its exacerbations. The primary risk factor for COPD is active and passive cigarette smoking [ 4 , 14 ]. Smoking alters both gut and lung microbiomes by changing the microecological structure of the mouth via several ways [ 5 , 7 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Lung and Gut Microbiome in COPD

Karakasidis

Kotsiou

Gourgoulianis

2023

JPM

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Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death worldwide. The association between lung and gut microbiomes in the pathogenesis of COPD has been recently uncovered. The goal of this study was to discuss the role of the lung and gut microbiomes in COPD pathophysiology. A systematic search of the PubMed database for relevant articles submitted up to June 2022 was performed. We examined the association between the lung and gut microbiome dysbiosis, reflected in bronchoalveolar lavage (BAL), lung tissue, sputum, and feces samples, and the pathogenesis and progression of COPD. It is evident that the lung and gut microbiomes affect each other and both play a vital role in the pathogenesis of COPD. However, more research needs to be carried out to find the exact associations between microbiome diversity and COPD pathophysiology and exacerbation genesis. Another field that research should focus on is the impact of treatment interventions targeting the human microbiome in preventing COPD genesis and progression.

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Proanthocyanidins supplemented diet alter anti-aging-markers and improved lifespan in Drosophila melanogaster model

Jaafaru,

Muhammad,

Mohammed

et al. 2024

Beni-Suef Univ J Basic Appl Sci

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Background It is unequivocally believed that phenolics and flavonoids from fruits and vegetables hold robust prevention potentials against age-related disease development through their abundant hydroxyl groups. This study explored the potential neuromuscular enhancement and anti-aging effects of dietary supplemented proanthocyanidins-rich fraction from Tamarindus indica on Drosophila melanogaster model. One- to three-day-old male and female D. melanogaster were fed with a proanthocyanidins-rich fraction-supplemented diet for 7 days at two different concentrations. Following the effective dose determination, longevity assay (rate of survival), behavioral assay (negative geotaxis and eclosion), and biochemical assays (aging and antioxidant enzymes activities) were conducted to assess the fraction’s longevity, antioxidant, and anti-aging effects on D. melanogaster model. Result The results showed a significant (p < 0.05) improvement in the rate of emergence and lifespan of the flies fed with proanthocyanidins-rich fraction-supplemented diet at both concentrations (1.5 mg/g and 2.5 mg/g) compared to the normal control. A significant decrease in acetylcholinesterase (AChE) activity and the level of caspase-3 and caspase-9 were observed in the D. melanogaster flies fed with the fraction-containing diet when compared with the normal control. The supplemented diet also significantly increases the activity of catalase, superoxide dismutase (SOD), and glutathione-s-transferase (GST) in a concentration-dependent manner but not nicotinamide quinone oxidoreductase one (NQO1) in D. melanogaster upon comparison with the normal control. Conclusion The observable changes in the experiment were attributed to the T. indica-derived proanthocyanidins, flavonoids with robust biological activities. The flavonoid-rich fraction proved its potential by enhancing the antioxidant system in D. melanogaster via the increase in the activities of some of the phase II antioxidant enzymes. The present study provides more insights into the wider perspectives of societies on the use of plant-derived natural compounds as the potential approach toward prevention against aging and age-related morbidities which enhance wellness and the quality of life in humans and animals.

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Prediction and enrichment analyses of the Homo sapiens-Drosophila melanogaster COPD-related orthologs: potential for modeling of human COPD genomic responses with the fruit fly

Cited by 4 publications

References 42 publications

Relating the Biogenesis and Function of P Bodies in Drosophila to Human Disease

Relating the Biogenesis and Function of P Bodies in Drosophila to Human Disease

Lung and Gut Microbiome in COPD

Proanthocyanidins supplemented diet alter anti-aging-markers and improved lifespan in Drosophila melanogaster model

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