Prediction and Monitoring of the Carcinogenicity of Polycyclic Aromatic Compounds (PACs)

Shaw, G. R.; Connell, Des

doi:10.1007/978-1-4612-2634-5_1

Cited by 50 publications

(28 citation statements)

References 117 publications

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“…PAHs are a class of widely spread mutagenic and tumorigenic environmental contaminants (1)(2)(3)(4)(5)(6)(7). They are produced mainly from incomplete combustion of organic materials during both natural events and human activities.…”

Section: Introductionmentioning

confidence: 99%

Environmental Carcinogenic Polycyclic Aromatic Hydrocarbons: Photochemistry and Phototoxicity

2002

Journal of Environmental Science and Health, Part C

341

252

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Section: Introductionmentioning

confidence: 99%

Environmental Carcinogenic Polycyclic Aromatic Hydrocarbons: Photochemistry and Phototoxicity

2002

Journal of Environmental Science and Health, Part C

341

252

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“…Polycyclic aromatic hydrocarbons (PAHs) are a class of genotoxic environmental contaminants [1][2][3][4][5][6]. PAHs are formed from incomplete combustion of fossil fuels during both natural events and human activities [3,5,7,8].…”

Section: Introductionmentioning

confidence: 99%

Photoirradiation of Polycyclic Aromatic Hydrocarbons with UVA Light – A Pathway Leading to the Generation of Reactive Oxygen Species, Lipid Peroxidation, and DNA Damage

Xia

Yan

et al. 2006

IJERPH

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Polycyclic aromatic hydrocarbons (PAHs) are a class of genotoxic environmental contaminants. We have long been interested in determining the mechanisms by which PAHs induce genotoxicity. Although the metabolic activation of PAHs leading to biological activities has been well studied, the photo-induced activation pathway has seldom reported. In this paper, we review the study of photoirradiation of PAHs with UVA irradiation results in (i) cytotoxicity and DNA damage (ii) DNA single strand cleavage; (iii) formation of 8-hydroxy-2'-deoxyguanosine adduct (8-OHdG), and (iv) formation of lipid peroxidation. Evidence has been shown that these photobiological activities are mediated by reactive oxygen species (ROS).

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“…In general, these nonpolar and hydrophobic molecules with two or more benzene rings persist in the environment. The effect and fate of PAHs in nature are of great environmental and human health concern due to their carcinogenic, mutagenic and teratogenic properties (Wilson & Jones 1993;Shaw & Connell 1994) as well as their high concentrations and frequency of occurrence in the environment (Sims & Overcash 1983;Jones et al 1989) and high persistence due to low solubility and bioavailability (USEPA 1985;Edwards 1988;Zaidi & Imam 1999). Human exposure to PAHs can occur through different environmental pathways including internal absorption through food and water consumption (Edwards et al 1983;Wild & Jones 1992).…”

Section: Introductionmentioning

confidence: 99%

Degradation of Benzo[a]Pyrene in Soil with Arbuscular Mycorrhizal Alfalfa

Liu

Luo

Cao

et al. 2004

Environmental Geochemistry and Health

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Mycorrhizal and non-mycorrhizal alfalfa (Medicago sativa) was grown in pots containing soil artificially contaminated with various levels of benzo[a]pyrene (B[a]P) (0, 1, 10 and 100 mg kg )1 ). Soil and plants were sampled after 30, 40, 50, 60 and 90 days and compared with unlanted pots. The percentage of mycorrhizal root length colonized by Glomus caledoniun was not significantly affected by the addition of B[a]P up to 10 mg kg )1 but was significantly lower at 100 mg kg )1 B[a]P compared with low concentrations (p < 0.05). There was no difference in soil polyphenol oxidase and dehydrogenase activity among the controls and applications of 1 and 10 mg kg )1 of B[a]P. However, enzyme activities were significantly higher at 100 mg kg )1 B[a]P compared with the other three treatments, and there was no mycorrhizal effect. Over a period of 90 days the concentration of B[a]P in soil in which alfalfa was grown was significantly lower than in unplanted soil (p < 0.05). Degradation rates of B[a]P added at 1, 10 and 100 mg kg )1 without G. caledonium were 76, 78 and 53%, and with mycorrhizal inoculation were 86, 87 and 57%. The degradation rate in unplanted soil was significantly lower than in planted soil, and was significantly higher in medium-and low-B[a]P treatments than in the high B[a]P concentration tested. There is a possibility of enhancement phytoremediation of PAHs in rhizosphere soil with arbuscular mycorrhizal fungi.

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Prediction and Monitoring of the Carcinogenicity of Polycyclic Aromatic Compounds (PACs)

Cited by 50 publications

References 117 publications

Environmental Carcinogenic Polycyclic Aromatic Hydrocarbons: Photochemistry and Phototoxicity

Environmental Carcinogenic Polycyclic Aromatic Hydrocarbons: Photochemistry and Phototoxicity

Photoirradiation of Polycyclic Aromatic Hydrocarbons with UVA Light – A Pathway Leading to the Generation of Reactive Oxygen Species, Lipid Peroxidation, and DNA Damage

Degradation of Benzo[a]Pyrene in Soil with Arbuscular Mycorrhizal Alfalfa

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