Prediction Models for Neonatal Health Care–Associated Sepsis: A Meta-analysis

Verstraete, Evelien; Blot, Koen; Mahieu, Ludo; Vogelaers, Dirk; Blot, Stijn

doi:10.1542/peds.2014-3226

Cited by 61 publications

(46 citation statements)

References 69 publications

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“…These can be listed as amniotic fluid cultures, serum procalcitonin, C-reactive protein (CRP) interleukin (IL)-6, IL-8, IL-10, IL-18, tumor necrosis factor-alpha (TNF-alpha), interferon gamma levels etc. [10].…”

Section: Discussionmentioning

confidence: 99%

The utility of maternal mean platelet volume levels for early onset neonatal sepsis prediction of term infants

Çekmez

Güleçoğlu²,

Özcan³

et al. 2017

Ginekol Pol

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Objectives: This study is aimed to evaluate the role of maternal mean platelet volume (MPV) levels for antenatal prediction marker of early onset neonatal sepsis in term infants born to mothers who have low infection risk. Material and methods:A total of 62 pregnant women who gave birth in our hospital and whose neonates were admitted to a third level Neonatal Intensive Care Unit due to confirmed neonatal sepsis between January 2010 and May 2016 were selected as a study group. Within the same period, 68 women who gave birth to healthy neonates were enrolled as a control group. We compared maternal MPV values which were evaluated before delivery. The receiver operating characteristic (ROC) curves were drawn to evaluate the values maternal MPV in the diagnosis of neonatal sepsis.Results: MPV levels were detected statistically higher in the study group than the control group (8.27 ± 1.85 vs. 8.98 ± 1.16) (p = 0.001). Conclusion:The maternal serum MPV level is a clinically useful, non-invasive and reliable marker in antenatal prediction of EOS.

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Section: Discussionmentioning

confidence: 99%

The utility of maternal mean platelet volume levels for early onset neonatal sepsis prediction of term infants

Çekmez

Güleçoğlu²,

Özcan³

et al. 2017

Ginekol Pol

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“…Different pathogens such as bacteria, viruses, fungi or parasites often present in a clinically indistinguishable pattern in neonates, and localised infections may present with systemic signs making the clinical diagnosis difficult and often impossible without imaging confirmation and/or laboratory support. Moreover, a number of non-infectious syndromes, such as respiratory distress syndrome in the premature infant, inborn errors of metabolism and congenital malformations such as serious cardiac anomalies, have initial clinical presentations similar to severe infections [11].…”

Section: Preamblementioning

confidence: 99%

Neonatal infections: Case definition and guidelines for data collection, analysis, and presentation of immunisation safety data

Vergnano

Buttery

Cailes

et al. 2016

Vaccine

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Maternal vaccination is an important area of research and requires appropriate and internationally comparable definitions and safety standards. The GAIA group, part of the Brighton Collaboration was created with the mandate of proposing standardised definitions applicable to maternal vaccine research. This study proposes international definitions for neonatal infections.The neonatal infections GAIA working group performed a literature review using Medline, EMBASE and the Cochrane collaboration and collected definitions in use in neonatal and public health networks. The common criteria derived from the extensive search formed the basis for a consensus process that resulted in three separate definitions for neonatal blood stream infections (BSI), meningitis and lower respiratory tract infections (LRTI). For each definition three levels of evidence are proposed to ensure the applicability of the definitions to different settings.Recommendations about data collection, analysis and presentation are presented and harmonized with the Brighton Collaboration and GAIA format and other existing international standards for study reporting.

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“…Prediction models for neonatal health care-associated sepsis were reviewed (29). The systematic search revealed nine articles with 12 prediction models representing 1295 suspected and 434 laboratory-confirmed sepsis episodes.…”

Section: Sepsismentioning

confidence: 99%

“…The paper stated prediction models should be considered as guidance rather than an absolute indicator because they all have limited diagnostic accuracy. Lethargy and pallor and or mottling for all neonates as well as apnea and or bradycardia and poor peripheral perfusion for very low birth weight neonates are the most powerful clinical signs and the clinical context of the neonate should always be considered (29).…”

Section: Sepsismentioning

confidence: 99%

Biomarkers, Trauma, and Sepsis in Pediatrics: A Review

Frieri¹,

Kumar²,

Boutin³

2016

J Pediatr Rev

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Context: There is a logical connection with biomarkers, trauma, and sepsis. This review paper provides new information and clinical practice implications. Biomarkers are very important especially in pediatrics. Procalcitonin and other biomarkers are helpful in identifying neonatal sepsis, defense mechanisms of the immune system. Pediatric trauma and sepsis is very important both in infants and in children. Stress management both in trauma is based upon the notion that stress causes an immune imbalance in susceptible individuals. Evidence Acquisition: Data sources included studies indexed in PubMed, a meta-analysis, predictive values, research strategies, and quality assessments. A recent paper by one of the authors stated marked increase in serum procalcitonin during the course of a septic process often indicates an exacerbation of the illness, and a decreasing level is a sign of improvement. A review of epidemiologic studies on pediatric soccer patients was also addressed. Keywords for searching included biomarkers, immunity, trauma, and sepsis. Results: Of 50 reviewed articles, 34 eligible articles were selected including biomarkers, predictive values for procalcitonin, identifying children at risk for intra-abdominal injuries, blunt trauma, and epidemiology, a meta-analysis. Of neonatal associated sepsis, the NF-kappa B pathway by inflammatory stimuli in human neutrophils, predictive value of gelsolin for the outcomes of preterm neonates, a metaanalysis interleukin-8 for neonatal sepsis diagnosis. Conclusions: Biomarkers are very important especially in pediatrics. Procalcitonin and other biomarkers are helpful in identifying neonatal sepsis, defense mechanisms, and physiological functions of the immune system. Pediatric trauma and sepsis is very important both in infants and in children. Various topics were covered such as biomarkers, trauma, sepsis, inflammation, innate immunity, role of neutrophils and IL-8, reactive oxygen species, neonatal hypoxia, NF-kappa B related to inflammation. These topics are clearly linked and are very important for pediatricians, pulmonologists, and immunologists in academic centers and in practice.

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Prediction Models for Neonatal Health Care–Associated Sepsis: A Meta-analysis

Cited by 61 publications

References 69 publications

The utility of maternal mean platelet volume levels for early onset neonatal sepsis prediction of term infants

The utility of maternal mean platelet volume levels for early onset neonatal sepsis prediction of term infants

Neonatal infections: Case definition and guidelines for data collection, analysis, and presentation of immunisation safety data

Biomarkers, Trauma, and Sepsis in Pediatrics: A Review

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