Prediction of calculated future cardiovascular disease by monocyte count in an asymptomatic population

Abstract

Introduction:Although atherogenesis is clearly entwined with systemic infl ammation, the risk-predictive relationship between preclinical and overt cardiovascular disease (CVD) and systemic white blood cell (WBC) subtypes remains unclear. Implication of an association would greatly facilitate cardiac risk prediction, assessment and monitoring. Methods: 1383 asymptomatic individuals (795 men, 588 women) attending for executive health screening were examined clinically as well as with phlebotomy and exercise stress testing to determine their ten-year risk of developing overt cardiovascular disease (as estimated by both Framingham and SCORE calculations). The signifi cance of their association with overall WBC and subtypes were determined using both univariate and multiple regression modeling. Results: Of all WBC subtypes, monocyte count was found to have the strongest, independent relationship with overall CVD risk by backwards linear regression modeling (Framingham: β = 0.057; p = 0.03; SCORE: β = 0.128; p = Ͻ0.0005). Independent associations with BMI (β = 5.214; p = Ͻ0.0005), waist circumference (β = 21.866; p = Ͻ0.0005), systolic blood pressure (β = 10.738; p = 0.003), HDL cholesterol (β = −0.639; p = Ͻ0.0005) and triglyceride concentrations (β = 0.787; p = Ͻ0.0005) were also evident. Overall WBC along with neutrophils, lymphocytes and basophil subfractions were variably (but less strongly) associated with such dependents and outcome measures. Conclusions: In conclusion, monocyte count, a simple inexpensive test, may provide useful predictive cardiovascular risk information in asymptomatic individuals to inform and guide attempts at interrupting CVD development at a preclinical stage.

Relation between resting amygdalar activity and cardiovascular events: a longitudinal and cohort study

“…13 Haemopoietic progenitors might accumulate in the circulation and the spleen and are thus poised to potentiate leucocyte supply by establishing extramedullary haemopoiesis. [34][35][36] In mice, bone-marrowderived monocytes released in response to variable stress or to stressful events (such as myocardial infarction) migrate to the arterial wall, where they instigate atherosclerotic infl ammation. 11,13,37 Results from animal studies 38 point to increased haemopoiesis and arterial infl ammation as important mechanisms in stress.…”

CD14 dim CD16 + and CD14 + CD16 + Monocytes in Obesity and During Weight Loss

“…3 The monocyte count is positively associated with body mass index (BMI) and triglycerides (TG) and is negatively related to high-density lipoprotein cholesterol. 4 Furthermore, clinical studies report that the monocyte count is also associated with subclinical peripheral atherosclerosis [5][6][7] and the development of cardiovascular disease. 4 Overall, it is proposed that the mononuclear phagocyte system contributes to the pathophysiology of cardiometabolic diseases (review in 8 ).…”

Polymorphism rs7023923 and monocyte count in blood donors and coronary artery disease patients

“…Clinical studies have demonstrated that monocytes play a key role in atherosclerosis [6,7], myocardial infarction (MI) [8], and healing after MI [9]. Monocytes are attracted to the coronary artery wall, where they differentiate to macrophages, become loaded with lipids, and remain trapped there.…”