Prediction of calculated future cardiovascular disease by monocyte count in an asymptomatic population

Abstract

Introduction:Although atherogenesis is clearly entwined with systemic infl ammation, the risk-predictive relationship between preclinical and overt cardiovascular disease (CVD) and systemic white blood cell (WBC) subtypes remains unclear. Implication of an association would greatly facilitate cardiac risk prediction, assessment and monitoring. Methods: 1383 asymptomatic individuals (795 men, 588 women) attending for executive health screening were examined clinically as well as with phlebotomy and exercise stress testing to determine their ten-year risk of developing overt cardiovascular disease (as estimated by both Framingham and SCORE calculations). The signifi cance of their association with overall WBC and subtypes were determined using both univariate and multiple regression modeling. Results: Of all WBC subtypes, monocyte count was found to have the strongest, independent relationship with overall CVD risk by backwards linear regression modeling (Framingham: β = 0.057; p = 0.03; SCORE: β = 0.128; p = Ͻ0.0005). Independent associations with BMI (β = 5.214; p = Ͻ0.0005), waist circumference (β = 21.866; p = Ͻ0.0005), systolic blood pressure (β = 10.738; p = 0.003), HDL cholesterol (β = −0.639; p = Ͻ0.0005) and triglyceride concentrations (β = 0.787; p = Ͻ0.0005) were also evident. Overall WBC along with neutrophils, lymphocytes and basophil subfractions were variably (but less strongly) associated with such dependents and outcome measures. Conclusions: In conclusion, monocyte count, a simple inexpensive test, may provide useful predictive cardiovascular risk information in asymptomatic individuals to inform and guide attempts at interrupting CVD development at a preclinical stage.

Mild Renal Dysfunction and Metabolites Tied to Low HDL Cholesterol Are Associated With Monocytosis and Atherosclerosis

“…HDL-C has been associated with monocyte count in studies one third to one fifth the size of the present study, both in healthy individuals and in subjects with the metabolic syndrome. 44,45 The present much larger study extends this primary observation to a new population, demonstrating that HDL-C plays an important role in the monocytosis of individuals with mild renal dysfunction measured by cysC. We additionally showed that AA metabolites tied to low HDL-C and insulin resistance 23 were associated with monocytosis and demonstrated a strong relationship of monocyte count with carotid IMT, which substantially implicates the present findings in atherogenesis.…”

Total and differential white blood cell counts, high-sensitivity C-reactive protein, and cardiovascular risk in non-affective psychoses

“…Outside of schizophrenia in the general population, total WBC (Orakzai et al, 2007; Park et al, 2010; Spencer et al, 2007) and monocyte (Waterhouse et al, 2008) counts, as well as C-reactive protein levels (Choi et al, 2004; Park et al, 2010), have been associated with cardiovascular disease risk. In the Framingham Offspring study, increased total WBC counts were associated with incident atrial fibrillation (Rienstra et al, 2012).…”

Modifications de l’immunité dans l’obésité : impact sur le risque infectieux

“…Par ailleurs, selon une autre étude [80], le taux des monocytes sanguins, acteurs importants de l'immunité innée, est corrélé à l'IMC ainsi qu'au taux des triglycérides. Cela concerne les deux sous-populations CD14 dim /CD16 + et CD14 + /CD16+ ; les monocytes CD16 + , contrairement aux CD16 -, stimulent la sécrétion du TNF␣ (pro-inflammatoire) et inhibent celle de l'IL-10 (antiinflammatoire) ; leur taux diminuerait lors d'une perte de poids [81].…”