Prediction of Clinical Outcome After Cardiac Surgery: The Role of Cytokines, Endotoxin, and Anti-Endotoxin Core Antibodies

Rothenburger, Markus; Soeparwata, Rasjid; Deng, Mario C.; Schmid, Çhristof; Berendes, Elmar; Tjan, T. D. T.; Wilhelm, Markus J.; Erren, Michael; Böcker, Dirk; Scheld, Hans H.

doi:10.1097/00024382-200116001-00009

Cited by 60 publications

(37 citation statements)

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“…These results are in agreement with reports showing that CPB increases inflammatory responses in the brain [4,7,[31][32][33][34][35].…”

Section: Discussionsupporting

confidence: 93%

Granulocyte-colony stimulating factor suppresses early inflammatory response of striatum in a cardiopulmonary bypass-circulatory arrest model of ischemic brain injury in newborn piglets

Pastuszko¹,

Schears²,

Kubin³

et al. 2013

WJCD

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We investigated the effect of Granulocyte-Colony Stimulating Factor (G-CSF) on expression of pro-and anti-inflammatory proteins in the striatum of newborn piglet brain following cardiopulmonary bypass (CPB) and deep hypothermic circulatory arrest (DHCA). Piglets were placed on CPB, cooled to 18˚C, subjected to 30 min of DHCA and 1 h of low-flow (20 ml/kg/min), rewarmed to 37˚C, separated from CPB circuit and monitored for 2 h. Striatum was then isolated for protein analysis. The levels of proteins are presented relative to the mean in the control group (mean ± SEM, n = 6). DHCA increased the levels of pro-inflammatory proteins: IL-1alpha (158%  23%, P = 0.05), IL-6 (152%  16%, P = 0.03), TNF-alpha (144%  2%, P = 0.003), MIP-3 alpha (148%  12.6%, P = 0.03), NAP-3 (216%  16%, P = 0.05), GRO (165%  19%, P = 0.03) and BLC (140.4  15%, P = 0.05). Compared to DHCA, the G-CSF-treated group had significantly decreased levels of IL-6 (110.8%  11% vs. 152%  16%, P = 0.05), TNF-alpha (120.6%  5.4% vs. 144%  2%, P = 0.001), MIP-3 alpha (148%  12.6% vs. 104.8%  13%, P = 0.02) and NAP-2 (216%  16% vs. 122%  23%, P = 0.002). The levels of anti-inflammatory proteins did not change in DHCA group compared to control, except for VEGF which decreased to 37.5%  9%, P = 0.003. The levels of all protective proteins in the G-CSF group increased versus the DHCA group, but the increases did not attain a P value of 0.05. Conclusions: In an immature brain subjected to circulatory arrest, the early inflammatory response in the striatum is diminished by pretreatment with G-CSF.

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“…These results are in agreement with reports showing that CPB increases inflammatory responses in the brain [4,7,[31][32][33][34][35].…”

Section: Discussionsupporting

confidence: 93%

Granulocyte-colony stimulating factor suppresses early inflammatory response of striatum in a cardiopulmonary bypass-circulatory arrest model of ischemic brain injury in newborn piglets

Pastuszko¹,

Schears²,

Kubin³

et al. 2013

WJCD

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“…Alkaline phosphatase may act like an acute phase protein, where high levels of physiological active alkaline phosphatase have a protective anti-inflammatory effect. The preoperative plasma levels may predict clinical outcome in acute inflammation in a manner similar to that reported for high plasma anti-endotoxin antibody levels (24,25). Patients might thus be protected by pretreatment with physiological active alkaline phosphatase which will elevate their endogenous physiological levels.…”

Section: Discussionmentioning

confidence: 64%

Prophylactic Treatment with Alkaline Phosphatase in Cardiac Surgery Induces Endogenous Alkaline Phosphatase Release

et al. 2012

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Document VersionPublisher's PDF, also known as Version of Record (includes final page, issue and volume numbers) Please check the document version of this publication:• A submitted manuscript is the author's version of the article upon submission and before peer-review. There can be important differences between the submitted version and the official published version of record. People interested in the research are advised to contact the author for the final version of the publication, or visit the DOI to the publisher's website.• The final author version and the galley proof are versions of the publication after peer review.• The final published version features the final layout of the paper including the volume, issue and page numbers. Link to publicationCitation for published version (APA): Kats, S., Brands, R., Hamad, M. A., Seinen, W., Scharnhorst, V., Wulkan, R. W., ... Oeveren, van, W. (2014). Prophylactic treatment with alkaline phosphatase in cardiac surgery induces endogenous alkaline phosphatase release. International Journal of Artificial Organs, 35(2), 144-151. DOI: 10.5301/ijao.5000039 General rightsCopyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal ? Take down policyIf you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.

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“…To our knowledge, it has not been reported previously that type 8 pneumococci can trigger IL-8 release or that IL-8 release can be regulated by type-specific antibodies to pneumococci. However, there is precedent for antibody-mediated downregulation of cellular IL-8 secretion by MAbs to a herpes simplex virus glycoprotein (44) and endotoxin (38). Downregulation of IL-8 has been implicated as a mechanism to dampen the inflammatory response to pneumococci (25), and a MAb to IL-8 (30) was shown to reduce the inflammatory response to experimental pneumococcal meningitis.…”

Section: Discussionmentioning

confidence: 99%

Modulation of Polymorphonuclear Cell Interleukin-8 Secretion by Human Monoclonal Antibodies to Type 8 Pneumococcal Capsular Polysaccharide

2003

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Prediction of Clinical Outcome After Cardiac Surgery: The Role of Cytokines, Endotoxin, and Anti-Endotoxin Core Antibodies

Cited by 60 publications

References 0 publications

Granulocyte-colony stimulating factor suppresses early inflammatory response of striatum in a cardiopulmonary bypass-circulatory arrest model of ischemic brain injury in newborn piglets

Granulocyte-colony stimulating factor suppresses early inflammatory response of striatum in a cardiopulmonary bypass-circulatory arrest model of ischemic brain injury in newborn piglets

Prophylactic Treatment with Alkaline Phosphatase in Cardiac Surgery Induces Endogenous Alkaline Phosphatase Release

Modulation of Polymorphonuclear Cell Interleukin-8 Secretion by Human Monoclonal Antibodies to Type 8 Pneumococcal Capsular Polysaccharide

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