Prediction of clinical outcome after stereotactic body radiotherapy for non-small cell lung cancer using diffusion-weighted MRI and 18F-FDG PET

Abstract

A low ADC value on pre-treatment DW-MRI and a high SUVmax may be associated with poor DP in NSCLC patients treated with SBRT. Using both values in combination was a better predictor.

Response assessment of stereotactic body radiation therapy using dynamic contrast‐enhanced integrated MR‐PET in non‐small cell lung cancer patients

“…Furthermore, our results demonstrated that a high pretreatment SUV max of the lung tumor correlated with disease progression, although the correlation was not statistically significant in the present study. Nonetheless, this result is consistent with published results . For example, the Ottawa University research group in Canada have shown that patients with an SUV max ≥7 on PET scan have poorer outcomes and a high risk of progression, mainly due to the aggressive biology of such tumors .…”

“…For example, the Ottawa University research group in Canada have shown that patients with an SUV max ≥7 on PET scan have poorer outcomes and a high risk of progression, mainly due to the aggressive biology of such tumors . Similarly, the Kyoto University group showed that low ADC values and high SUV values (≥7.9) before treatment predict disease progression . The changes in tumor glucose metabolism induced by anticancer treatments are predictive of patient outcome; the use of MR‐PET can help to stratify patients by probability of disease progression.…”

“…Nonetheless, this result is consistent with published results. 26,29 For example, the Ottawa University research group in Canada have shown that patients with an SUV max 7 on PET scan have poorer outcomes and a high risk of progression, mainly due to the aggressive biology of such tumors. 26 Similarly, the Kyoto University group showed that low ADC values and high SUV values (7.9) before treatment predict disease progression.…”

“…26 Similarly, the Kyoto University group showed that low ADC values and high SUV values (7.9) before treatment predict disease progression. 29 The changes in tumor glucose metabolism induced by anticancer treatments are predictive of patient outcome; the use of MR-PET can help to stratify patients by probability of disease progression. These results potentially allow treatment strategies to be selected for patient subgroups that would benefit from SBRT dose escalation; they may also guide clinicians in establishing a more intensive follow-up to detect early tumor recurrence, as well as a more aggressive treatment strategy, including systemic or targeted varieties of radiotherapy.…”

Lung Cancer: Short‐Term Reproducibility of Intravoxel Incoherent Motion Parameters and Apparent Diffusion Coefficient at 3T

“…In oncological imaging, diffusion‐weighted imaging (DWI) is increasingly used as a radiation‐free, noncontrast, minimally invasive physiologic imaging technique. Its quantitative parameter, the apparent diffusion coefficient (ADC), is a potential tool to predict and monitor the early response to lung cancer . However, ADC is influenced by both diffusion and perfusion effects.…”