“…The cardiovascular response to exercise has been widely documented by several investigators (Dexter, Whittenberger, Haynes, Goodale, Gorlin & Sawyer 1951) (Barger, Richards, Metcalfe & Gunther 1956) (Freedman, Snider, Brostoff, Kimelblot & Katz 1955) (Reeves, Grover, Filley & Blount 1961a) (Reeves, Grover, Filley & Blount 1961b) (Rowland, Popowski & Ferrone 1997) (Kobayashi, Andoh, Fujinami, Nakayama, Takada, Takeuchi & Okamoto 1978) (Reeves, Grover & Filley 1961) (Bevegard, Freyschuss & Strandell 1966) (Astrand, Cuddy, Saltin & Stenberg 1964) (Denniston, Maher, Reeves, Cruz, Cymerman & Grover 1976) (Stenberg, Astrand, Ekblom, Royce & B 1967) (Turley & Wilmore 1997) (Fairbarn, Blackie, McElvaney, Wiggs, Pare & Pardy 1994) (Allor, Pivarnik, Sam & Perkins 2000) (Richard, Lonsdorfer-wolf, Dufour, Doutreleau, OswaldMammosser, Billat & Lonsdorfer 2004). Some of the reports demonstrated a linear function between the cardiac output (CO) and oxygen uptake rate during steady state of graded exercise, with a slope of approximately 5-6 in normal and athletic subjects (Rowell 1986).…”